公开(公告)号：US20220128518A1

公开(公告)日：2022-04-28

申请号：US17423101

申请日：2020-01-13

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Edward D. MROZ ,  Heng HE

IPC: G01N30/16 ,  G01N30/68

Abstract: A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.

公开(公告)号：US11275062B2

公开(公告)日：2022-03-15

申请号：US16833181

申请日：2020-03-27

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC: G01N30/20 ,  G01N30/32 ,  G01N30/02

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

公开(公告)号：USD941488S1

公开(公告)日：2022-01-18

申请号：US29723537

申请日：2020-02-07

Applicant: Agilent Technologies, Inc.

Designer： Longbin Fang ,  Qiting Ye ,  Xin Yao ,  Zhi Tao ,  Jian Wu ,  Nan Li ,  Xiaobo Wang

公开(公告)号：US11209389B2

公开(公告)日：2021-12-28

申请号：US16409356

申请日：2019-05-10

Applicant: Agilent Technologies, Inc.

Inventor： Ludwig Gutzweiler

IPC: G01N27/447 ,  B01D15/36 ,  B01L3/00

Abstract: A method of handling a fluidic sample in a sample separation device includes at least partly immobilizing the fluidic sample by an immobilizing agent inhibiting spatial broadening of the fluidic sample, and subsequently at least partly releasing the fluidic sample from the immobilizing agent.

公开(公告)号：US20210394081A1

公开(公告)日：2021-12-23

申请号：US17351084

申请日：2021-06-17

Applicant: Agilent Technologies, Inc.

Inventor： Jose-Angel Mora ,  Uwe Effelsberg ,  Lena Höninger

IPC: B01D15/16 ,  G01N30/30 ,  B01D15/12

Abstract: A thermal impact assembly for a sample separation apparatus for separating a fluidic sample in a mobile phase by a sample separation unit includes a thermal impact device configured for thermally impacting the fluidic sample and/or the mobile phase and the sample separation unit, and a control unit configured for controlling the thermal impact device for thermally impacting the fluidic sample and/or the mobile phase on the one hand and for thermally impacting the sample separation unit on the other hand independently from each other.

公开(公告)号：US20210389282A1

公开(公告)日：2021-12-16

申请号：US17288478

申请日：2018-10-26

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann

IPC: G01N30/20 ,  B01D15/18 ,  G01N30/22 ,  G01N30/46 ,  G01N30/60

Abstract: An injector, for injecting a fluidic sample in at least one selected one of a first sample separation apparatus and a second sample separation apparatus, includes a valve arrangement fluidically connectable to the first sample separation apparatus and the second sample separation apparatus, a sample accommodation volume for accommodating the fluidic sample, and a control unit configured for controlling the valve arrangement so that fluidic sample in the sample accommodation volume is selectively injectable into the selected first sample separation apparatus and/or second sample separation apparatus.

公开(公告)号：US20210263043A1

公开(公告)日：2021-08-26

申请号：US17319868

申请日：2021-05-13

Applicant: Agilent Technologies, Inc.

Inventor： Michael J. Kimzey

IPC: G01N33/68 ,  G01N33/53 ,  C09B19/00 ,  C09B57/02 ,  C09B57/08 ,  C12P19/04 ,  G01N33/58

Abstract: The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or gly-copeptides.

公开(公告)号：US11072829B2

公开(公告)日：2021-07-27

申请号：US16555683

申请日：2019-08-29

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Dirk Goossens ,  Joachim De Schrijver ,  Jurgen Del Favero

IPC: C12Q1/68 ,  C12Q1/6883 ,  C12Q1/6809

Abstract: The present invention relates to the technical field of organ and tissue transplantation and specifically to methods allowing rejection of transplanted organs and tissues by a transplant patient. The present invention provides methods for non-invasive and ex vivo or in vitro detection of the presence or absence of transplant rejection, i.e. transplant health or rejection. The present methods allow for effective and continuous monitoring of transplant status with a minimal or absent discomfort for a transplant patent.

公开(公告)号：US11053546B2

公开(公告)日：2021-07-06

申请号：US15737105

申请日：2016-07-13

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Jurgen Peter Lode Del Favero ,  Michaël Vyverman ,  Paul Vauterin

IPC: G16B20/00 ,  G16H50/20 ,  C12Q1/6881 ,  C12Q1/6827 ,  G16H10/40 ,  G01N33/49 ,  G01N33/68

Abstract: A method for estimating whether a female is pregnant, said method comprising measuring allele presences (D) for a plurality of genetic markers of at least one chromosome, different from the X and Y chromosome, in a sample of cell-free DNA from a potentially pregnant female; each allele presence representing the presence at a genetic marker of at least one of: a reference allele of maternal or foetal origin, and an alternative allele of maternal or foetal origin; based on said measured allele presences, determining a homozygous fraction (Fho) thereof which is associated with purely homozygous genetic markers; and estimating whether the female is pregnant based on said fraction.

公开(公告)号：US11022111B2

公开(公告)日：2021-06-01

申请号：US14633281

申请日：2015-02-27

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Bernhard Dehmer ,  Arne Kurz ,  Lothar Mitzlaff

IPC: F04B53/22 ,  F04B19/22 ,  F04B37/00 ,  F04B39/14 ,  F04B53/14 ,  F04B53/16 ,  B01D15/14 ,  B01D19/00 ,  F04B17/03

Abstract: A pump for pumping fluid, wherein the pump comprises a pump head comprising a working chamber, a piston assembly configured for reciprocating within the working chamber to thereby displace fluid, a pump base accommodating a piston actuator being mechanically lockable to the piston assembly in a working mode of the pump to thereby transmit drive energy to the piston assembly to reciprocate, and a locking/unlocking mechanism configured to, upon unfastening the pump head from the pump base, mechanically unlock the piston actuator from the piston assembly in a maintenance mode of the pump.