公开(公告)号：US11484625B2

公开(公告)日：2022-11-01

申请号：US16762398

申请日：2018-11-08

Applicant: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California

Inventor： Yang Chai ,  Yong Chen ,  Yuan Yuan ,  Yuxing Guo ,  Xiangjia Li ,  Zoe Johnson

IPC: A61L27/38 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61F2/28 ,  C08L67/04

Abstract: This invention relates to a bone regeneration product comprising at least one stem cell, at least one scaffold, and at least one stem cell. The stem cells suitable for this invention may comprise stem cells suitable for a dense bone regeneration, stem cells suitable for a spongy bone regeneration, or a combination thereof. The bone regeneration product may further comprise a growth factor. This invention also relates to a bone regeneration method and treatment of any bone that has a critical size defect. This invention also relates to a scaffold. This invention further relates to a 3D printed scaffold comprising hydroxyapatite (HA) and tricalcium phosphate (TCP). This invention also relates to a scaffold comprising a polymer. The polymer of this invention may be prepared by using photocurable polymers and/or monomers. The scaffold of this invention may comprise a growth factor and a small molecule. The small molecule N may be a Smurf1 inhibitor.

公开(公告)号：US11478272B2

公开(公告)日：2022-10-25

申请号：US16280956

申请日：2019-02-20

Applicant: University of Southern California

Inventor： Mark S. Humayun

IPC: A61B17/34 ,  A61B17/00 ,  A61B17/02

Abstract: A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.

公开(公告)号：US11467575B2

公开(公告)日：2022-10-11

申请号：US16455360

申请日：2019-06-27

Applicant: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC. ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： James P. Kapinski ,  Jyotirmoy V. Deshmukh ,  Danil Prokhorov

IPC: G05D1/00 ,  G06N3/08 ,  G06N3/00 ,  G06N3/04

Abstract: Systems and methods are provided for implementing safety-aware artificial intelligence (AI) that can be used for autonomously controlling systems, such as an autonomous vehicle, in a manner that is proven to satisfy given safety constraints. Additionally, a safety-aware training technique can be applied to learned AI-based models, such as neural networks. The safety-aware training techniques can apply automated reasoning tools (ART) while the AI model is trained, in order to produce a model that is provable safe with respect to the safety constraints. The ART can integrate verification into the training process, and thereby dynamically re-train the model based on the safety verification in a feedback loop approach. The ART can be configured to either verify that the AI model is provably safety, or to provide updates to the training parameters used during to re-train the AI model in instances when the safety verification has failed.

公开(公告)号：US20220283185A1

公开(公告)日：2022-09-08

申请号：US17637700

申请日：2020-08-27

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Melanie D. Sweeney ,  Abhay P. Sagare ,  Berislav V. Zlokovic

IPC: G01N33/68 ,  G01N21/66 ,  G01N33/577 ,  G01N21/76

Abstract: A highly sensitive immunoassay has been developed and validated. In various embodiments, the assay comprises an immunoassay usable to measure soluble PDGFRβ (sPDGFR-β) in a human biofluid sample such as cerebrospinal fluid (CSF). In various embodiments, elevated sPDGFR-β in a human biofluid sample reflects pericyte and blood-brain barrier (BBB) injury, and is therefore an early biomarker of human cognitive dysfunction, dementia, and/or Alzheimer's disease.

公开(公告)号：US20220257655A1

公开(公告)日：2022-08-18

申请号：US17618240

申请日：2020-06-12

Applicant: The Regents of the University of California ,  University of Southern California

Inventor： Yu Jeong Kim ,  Yan-Ruide Li ,  Pin Wang ,  Lili Yang ,  Jiaji Yu

IPC: A61K35/17 ,  C12N5/0783 ,  C12N15/62 ,  C12N15/11 ,  C12N9/22 ,  A61P37/06 ,  A61P35/00

Abstract: Aspects of the present disclosure relate to methods and compositions related to the preparation of immune cells, including engineered immune cells. Certain embodiments of the disclosure include compositions, cells, and methods related to engineered invariant natural killer T (iNKT) cells for off-the-shelf use for clinical therapy. The iNKT cells may be produced from hematopoietic stem progenitor cells and may be suitable for allogeneic cellular therapy because they are HLA negative. In some aspects, the cells have imaging and suicide targeting capabilities.

公开(公告)号：US20220227803A1

公开(公告)日：2022-07-21

申请号：US17281424

申请日：2019-10-04

Applicant: University of Southern California

Inventor： Yong Zhang ,  Zhefu Dai ,  Xiao-Nan Zhang

IPC: C07H19/20 ,  C12P19/28 ,  A61K31/7076

Abstract: This disclosure provides a method of synthesis of 4′-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4′-thioribose NAD+ and compounds related thereto.

公开(公告)号：US20220227503A1

公开(公告)日：2022-07-21

申请号：US17568462

申请日：2022-01-04

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： David BARNHART ,  Rahul RUGHANI ,  Tyler PRESSER

IPC: B64G1/24 ,  B64G1/36 ,  B64G1/10 ,  G06N3/12

Abstract: A control system includes a target spacecraft and a swarm of chaser spacecraft. Each chaser spacecraft is controlled to follow a corresponding computed trajectory. The system also includes at least one computing device that executes a nested genetic algorithm. The nested genetic algorithm includes multiple guidance genetic algorithms and an outer genetic algorithm. Characteristically, each chaser spacecraft has an associated guidance genetic algorithm that determines a computed trajectory for the chaser spacecraft associated therewith. Advantageously, the outer genetic algorithm checks for collisions and is configured to alter one or more computed trajectories to avoid collisions.

公开(公告)号：US11376344B2

公开(公告)日：2022-07-05

申请号：US16693646

申请日：2019-11-25

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： John J. Whalen, III ,  Niki Bayat ,  Yi Zhang ,  Paulo Falabella ,  Mark E. Thompson ,  Mark S. Humayun

IPC: A61L24/06 ,  A61L24/00 ,  A61L15/60 ,  A61F9/007 ,  A61B17/00

Abstract: The present disclosure describes, among other things, a thereto-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.

公开(公告)号：US11359008B2

公开(公告)日：2022-06-14

申请号：US16375661

申请日：2019-04-04

Applicant: University of Southern California

Inventor： Wei Li ,  David Woodley ,  Mei Chen ,  Divya Sahu ,  Hangming Dong ,  Mengchen Zou

IPC: C07K16/18 ,  A61K39/395 ,  C07K16/28 ,  C12N15/113 ,  C12N15/13

Abstract: Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90α and methods of using the same to treat HIF-1a-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP in Hsp90α or VKHFSVEGQ in Hsp90α.

公开(公告)号：US20220181562A1

公开(公告)日：2022-06-09

申请号：US17539382

申请日：2021-12-01

Applicant: University of Southern California

Inventor： Tian-Yi LI ,  Peter I. DJUROVICH ,  Mark E. THOMPSON

IPC: H01L51/00 ,  C09K11/06 ,  C09K11/02 ,  C07F1/00

Abstract: Compounds comprising a first ligand and a second ligand; wherein the first ligand coordinates to a first metal through a first metal-carbene bond; the second ligand coordinates to a second metal through a second metal-carbene bond; the second ligand also coordinates to the first metal; the first ligand can link to the second ligand to form a multidentate ligand; and the first metal and the second metal are each independently selected from the group consisting of Au, Ag, and Cu can act as electron acceptors in tandem to increase the energy separation between the ground and excited state, which is higher than those found in analogous monometallic complexes. These compounds should find application as luminescent materials in organic light emitting diodes (OLEDs).