公开(公告)号：US20130066564A1

公开(公告)日：2013-03-14

申请号：US13231661

申请日：2011-09-13

Applicant: David E. Forsyth

Inventor： David E. Forsyth

IPC: G06F19/00

CPC classification number: G01N21/643 ,  G01N21/274 ,  G01N33/00 ,  G01N2021/6432 ,  G01N2201/1211 ,  G01N2201/1218 ,  G01N2201/126 ,  G01N2201/127 ,  G01N2201/12746 ,  G06F17/40 ,  G06F19/00

Abstract: An oxygen sensing system including an oxygen sensor, a microprocessor and one or more additional sensors for sensing parameters associated with the environment or with the oxygen sensor, accounts for one or more sensed conditions when calculating oxygen levels. The one or more sensors may sense conditions associated with environmental effects or effects of use that may cause the oxygen sensor to degrade over usage or over time. A baseline amplification and measurement circuit coupled to the oxygen sensor may enable the sensor to operate less frequently or for shorter periods of time, thereby increasing the life span, calibration hold time of the sensor, and reducing power requirements.

Abstract translation: 包括氧传感器，微处理器和用于感测与环境相关联的参数或氧传感器的一个或多个附加传感器的氧气感测系统在计算氧水平时考虑了一个或多个感测到的状况。 一个或多个传感器可以感测与环境影响或使用效果相关的条件，这可能导致氧传感器在使用或时间上降级。 耦合到氧传感器的基线放大和测量电路可以使得传感器能够较少频繁地操作或者更短的时间段，由此增加寿命，传感器的校准保持时间和降低功率需求。

公开(公告)号：US20110149097A1

公开(公告)日：2011-06-23

申请号：US12751816

申请日：2010-03-31

Applicant: Gaudenz Danuser ,  Paul C. Goodwin

Inventor： Gaudenz Danuser ,  Paul C. Goodwin

IPC: H04N5/228 ,  G01J1/58

CPC classification number: G01N21/6428 ,  G01N21/636 ,  G01N21/6458 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2201/126 ,  G02B21/365 ,  G02B21/367 ,  G06T3/4053

Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.

Abstract translation: 本发明的实施例涉及成像技术，特别涉及一种随时间检测相对较弱信号的成像系统，并且使用所检测的信号来确定信号发射器的位置。 本发明的具体实施方案涉及用于成像荧光团标记的样品的方法和系统，以便以明显大于与光学显微镜相关联的衍射限制分辨率的分辨率产生样品的图像。 本发明的实施例采用重叠 - 发射 - 图像消歧以允许从密集布置的发射器收集数据，这显着减少用于产生中间图像的数据收集时间以及计算构建高分辨率所需的中间图像的数量 最终图像。 本发明的另外的实施例采用分层图像处理技术来进一步解析和解释消歧图像。

公开(公告)号：US20080212960A1

公开(公告)日：2008-09-04

申请号：US11978138

申请日：2007-10-26

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: H04B17/00 ,  H04B10/08

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

公开(公告)号：US20020062202A1

公开(公告)日：2002-05-23

申请号：US09955858

申请日：2001-09-19

Applicant: Olympus Optical co., Ltd.

Inventor： Yujin Arai

IPC: G06F019/00

CPC classification number: G01N21/6452 ,  G01N21/6458 ,  G01N2201/10 ,  G01N2201/126 ,  G02B21/008 ,  G02B21/367

Abstract: An image data acquisition method comprises scanning a sample by a light, receiving a light from the sample, to acquire a scanned image data, and storing the scanned image data obtained by scanning a region of a predetermined size every time a region scanned by the light reaches a predetermined size, sequentially.

Abstract translation: 一种图像数据采集方法，包括用光进行样本的扫描，接收来自样本的光，获得扫描图像数据，并存储通过扫描由光照射的区域每隔预定尺寸区域获得的扫描图像数据 顺序达到预定尺寸。

公开(公告)号：US5284139A

公开(公告)日：1994-02-08

申请号：US815925

申请日：1991-12-30

Applicant: Gamal-Eddin Khalil ,  David P. Brown

Inventor： Gamal-Eddin Khalil ,  David P. Brown

IPC: G01N21/27 ,  G01N21/31 ,  A61B5/00 ,  A61B5/02 ,  F21V9/16 ,  G01N33/48

CPC classification number: G01N21/27 ,  G01N2021/3144 ,  G01N2201/1211 ,  G01N2201/126

Abstract: A method for converting a value for the partial pressure of oxygen (pO.sub.2) in blood at a measurement temperature to a corresponding value at a reference temperature (37.degree. C.). A value for pO.sub.2 is determined by measurements made in a patient's blood stream using a phosphorescent compound that is sensitive to the concentration of oxygen. The phosphorescent compound is illuminated with a short pulse of light, causing it to produce a phosphorescent emission having a rate of decay that varies as the function of the partial pressure of oxygen in the blood surrounding the phosphorescent compound. A detector produces an electrical signal corresponding to the intensity of the phosphorescent emission, and the electrical signal is converted to a corresponding digital value for input to a microcomputer. Also supplied to the microcomputer in digital form is a signal indicative of the temperature at the measurement site where the phosphorescent compound is disposed. The microcomputer determines the phosphorescent decay rate and from that value, determines the pO.sub.2 at the measurement site for the temperature at which the measurement was made. An initial estimate of a corresponding value for pO.sub.2 at the reference temperature is made as a function of the measurement temperature and the pO.sub.2 at that temperature. A more accurate estimate of pO.sub.2 at the reference temperature is iteratively determined by successively evaluating an expression that is a function of the initial measurement and a previous more accurate estimate. If the measurement temperature is less than the reference temperature, the current more accurate estimate is replaced by the average of the previous two estimates. A final more accurate estimate representing the value for pO.sub.2 at the reference temperature is then displayed.

Abstract translation: 将测定温度的血液中的氧分压值（pO2）转换为基准温度（37℃）下的对应值的方法。 通过使用对氧浓度敏感的磷光化合物在患者血液中进行的测量来确定pO2的值。 用短脉冲光照射磷光化合物，使其产生具有随着磷光化合物周围的血液中的氧分压的函数而变化的衰减速率的磷光发射。 检测器产生对应于磷光发射强度的电信号，并且将电信号转换成相应的数字值以输入微计算机。 还以数字形式提供给微型计算机是指示设置磷光化合物的测量部位处的温度的信号。 微型计算机确定磷光衰减速率，从该值确定在测量部位进行测量的温度下的pO2。 在参考温度下对pO2的相应值的初始估计作为测量温度和该温度下的pO2的函数。 通过连续评估作为初始测量的函数的表达式和先前的更准确的估计，迭代地确定参考温度下pO2的更准确的估计。 如果测量温度低于参考温度，则当前更准确的估计值将被前两次估计值的平均值所替代。 然后显示表示参考温度下pO2值的最终更准确的估计。

公开(公告)号：US5214593A

公开(公告)日：1993-05-25

申请号：US610416

申请日：1990-11-07

Applicant: Haakon T. Magnussen, Jr. ,  Roy P. Moeller

Inventor： Haakon T. Magnussen, Jr. ,  Roy P. Moeller

IPC: G01N21/27 ,  G01N21/85 ,  G01N30/74

CPC classification number: G01N21/274 ,  G01N21/85 ,  G01N2201/0662 ,  G01N2201/126 ,  G01N30/74

Abstract: A method and accompanying apparatus for automatically extending the linear dynamic absorbance range of absorbance detectors including multi-lightpath flow cells. The absorbance of a reference beam in a relatively short reference path is multiplied by a ratio of the absorbance of a sample beam in a relatively long sample path to the reference path absorbance in developing a relative absorbance for the sample path beyond its linear dynamic range.

Abstract translation: 一种用于自动扩展包括多光路流动池的吸光度检测器的线性动态吸光度范围的方法和伴随装置。 在相对较短的参考路径中的参考光束的吸光度乘以相对长的取样通道中的样品光束的吸光度与参考光路的吸光度之比，使得样品路径的相对吸光度超过其线性动态范围。

公开(公告)号：US5095913A

公开(公告)日：1992-03-17

申请号：US522208

申请日：1990-05-11

Applicant: Mark Yelderman ,  Daniel S. Goldberger ,  James R. Braig

Inventor： Mark Yelderman ,  Daniel S. Goldberger ,  James R. Braig

IPC: A61B5/083 ,  G01J1/24 ,  G01J5/12 ,  G01N21/31 ,  G01N21/35

CPC classification number: G01N21/3504 ,  A61B5/083 ,  G01J1/24 ,  G01J5/12 ,  G01N2021/3166 ,  G01N2201/126

Abstract: Methods and apparatus for constructing optically stabilized, shutterless infrared capnographs are disclosed. The capnographs of the present invention provide the absolute concentration of the constituents of the respiratory airstream of a patient, without the thermal drift problems normally associated with thermopile detectors, thereby providing a device with a high degree of accuracy. The present invention eliminates the need for a mechanical shutter to modulate the incident infrared beam and the need for a modulated source, thereby increasing the reliability and response time of the devices disclosed. Capnographs which are substantially unaffected by changes in the ambient temperature at which they operate are provided by connecting pairs of optically filtered thermopiles in series and processing the resulting differential pair.

Abstract translation: 公开了用于构造光学稳定的无闸门红外捕集仪的方法和装置。 本发明的血氧监护仪提供了患者的呼吸气流的成分的绝对浓度，而没有通常与热电堆检测器相关的热漂移问题，从而提供高精度的装置。 本发明不需要机械快门来调制入射的红外光束和调制源的需要，从而增加所公开的设备的可靠性和响应时间。 基本上不受其工作环境温度变化影响的测井仪通过串联连接成对的光学过滤的热电堆并处理所得的差分对来提供。

公开(公告)号：US4918311A

公开(公告)日：1990-04-17

申请号：US181929

申请日：1988-04-15

Applicant: Raymond E. Rogers

Inventor： Raymond E. Rogers

IPC: G01N21/61 ,  G01J1/18 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35

CPC classification number: G01N21/3504 ,  G01N21/274 ,  G01J1/18 ,  G01N2021/3129 ,  G01N2201/1211 ,  G01N2201/126

Abstract: An arrangement for ensuring the stability of the set point for a gas analyzer is disclosed. The set point control circuit utilizes an amplifier which is alternately switched between a reference voltage and a sensor signal to provide a signal to a processor representing the reference signal and the sensor signal. The processor compares the two signals and adjusts the heater associated with the sensor to provide a stable set point for the gas analyzer. The arrangement eliminates the need for precision resistors within the set point control circuit and therefore significantly reduces the cost of the circuitry.

Abstract translation: 公开了一种用于确保气体分析器的设定点的稳定性的装置。 设定点控制电路利用在基准电压和传感器信号之间交替切换的放大器，以向表示参考信号和传感器信号的处理器提供信号。 处理器比较两个信号并调节与传感器相关联的加热器，为气体分析仪提供稳定的设定点。 该布置消除了对设定点控制电路内的精密电阻的需要，因此显着降低了电路的成本。

公开(公告)号：US4892405A

公开(公告)日：1990-01-09

申请号：US256568

申请日：1988-10-12

Applicant: Keld Sorensen ,  James N. Macri ,  Timothy J. Douros ,  Paul Sajda ,  Emiddio V. Ippolito

Inventor： Keld Sorensen ,  James N. Macri ,  Timothy J. Douros ,  Paul Sajda ,  Emiddio V. Ippolito

IPC: G01N21/27 ,  G01N21/29 ,  G12B13/00

CPC classification number: G01N21/274 ,  G12B13/00 ,  G01N21/293 ,  G01N2201/0446 ,  G01N2201/126

Abstract: An apparatus for the calibration and quality assurance of a multichannel spectrophotometer, particularly an ELISA spectrophotometer, comprises a series of filters having a known first color and linearly increasing optical density. The response of the spectrophotometer is measured against the known color and linearly increasing optical density. Additional filters of at least one additional color permit checking the color response of the spectrophotmeter. An algorithm determines whether the response conforms to predetermined conditions. An output is produced to provide a record of the calibration and quality assurance of the spectrophotometer. The invention has particular utility for conducting calibration and quality assurance of ELISA spectrophotometers used in clinical laboratory screening for infectious diseases, such as Hepatitis B and the AIDS viruses.

Abstract translation: 用于多通道分光光度计，特别是ELISA分光光度计的校准和质量保证的装置包括具有已知的第一颜色和线性增加的光密度的一系列滤光器。 根据已知的颜色和线性增加的光密度测量分光光度计的响应。 至少一种额外的颜色的附加过滤器允许检查分光光度计的颜色响应。 算法确定响应是否符合预定条件。 产生输出以提供分光光度计的校准和质量保证的记录。 本发明具有用于进行临床实验室筛查感染性疾病如乙型肝炎和艾滋病病毒的ELISA分光光度计的校准和质量保证的特殊用途。

公开(公告)号：US4825076A

公开(公告)日：1989-04-25

申请号：US060996

申请日：1987-06-09

Applicant: John Shields

Inventor： John Shields

IPC: G01N21/3577 ,  G01J3/42 ,  G01N21/03 ,  G01N21/35

CPC classification number: G01N33/04 ,  G01N21/3577 ,  G01N2021/3129 ,  G01N21/0332 ,  G01N21/314 ,  G01N2201/126 ,  G01N2201/12753

Abstract: An optical cell and detector assembly for a spectrophotometric analyzing apparatus which comprises a sample cell having walls of optically transparent material defining a sample cavity having closely adjacent the sample cavity a radiation detector and adjacent an opposite wall a lens whereby to focus radiation passing through the cell onto the detector. The apparatus may also comprise optical means for focussing the beam onto the sample cell, chopper means for periodically obscuring the beam, and filter means for selecting one or more wavelengths from the beam. The sample under test is an aqueous emulsion and the filters are chosen to determine the concentration of the non aqueous components of the emulsion by measuring the water displaced by the components.

Abstract translation: 一种用于分光光度分析装置的光学单元和检测器组件，其包括具有光学透明材料壁的样品池，所述样品池具有限定样品腔的壁，所述样品腔具有与样品腔紧密相邻的辐射检测器，并且与相对的壁相邻，透镜通过所述透镜， 到检测器上。 该装置还可以包括用于将光束聚焦到采样单元上的光学装置，用于周期性地模糊光束的斩波装置，以及用于从该光束中选择一个或多个波长的滤光装置。 所测试的样品是水性乳液，并且通过测量被组分置换的水来选择过滤器以确定乳液的非水性组分的浓度。