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    Spectral bio-imaging data for cell classification using internal reference
    1.
    发明授权
    Spectral bio-imaging data for cell classification using internal reference 失效
    使用内部参考的细胞分类的光谱生物成像数据

    公开(公告)号：US06690817B1

    公开(公告)日：2004-02-10

    申请号：US09157138

    申请日：1998-09-18

    Applicant: Dario Cabib ,  Robert A. Buckwald ,  Nissim Ben-Yosef

    Inventor： Dario Cabib ,  Robert A. Buckwald ,  Nissim Ben-Yosef

    IPC: G06K962

    CPC classification number: G01B11/0675 ,  G01J3/02 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/453 ,  G01J5/10 ,  G01J2003/2866 ,  G01N1/30 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/582 ,  G01N2021/6417 ,  G06K9/00127 ,  G06K9/76

    Abstract: A method of spectral-morphometric analysis of biological samples, the biological samples including substantially constant components and suspected variable components, the method is effected by following the steps of (a) using a spectral data collection device for collecting spectral data of picture elements of the biological samples; (b) defining a spectral vector associated with picture elements representing a constant component of at least one of the biological samples; (c) using the spectral vector for defining a correcting function being selected such that when operated on spectral vectors associated with picture elements representing other constant components, spectral vectors of the other constant components are modified to substantially resemble the spectral vector; (d) operating the correcting function on spectral vectors associated with at least the variable components for obtaining corrected spectral vectors thereof; and (e) classifying the corrected spectral vectors into classification groups.

    Abstract translation: 生物样品的光谱 - 形态测定分析方法，生物样品包括基本不变的组分和可疑的可变组分，该方法是通过以下步骤来实现的：（a）使用光谱数据采集装置，用于收集图像元素的光谱数据 生物样品; （b）定义与表示至少一个生物样品的恒定分量的图像元素相关联的光谱矢量; （c）使用频谱矢量来定义被选择的校正函数，使得当与表示其他恒定分量的图像元素相关联的频谱矢量操作时，修改其他常数分量的谱矢量以基本上类似于频谱矢量; （d）对与至少可变分量相关联的频谱矢量操作校正函数，以获得其校正的频谱矢量; 和（e）将校正的光谱向量分类为分类组。

    Spectral bio-imaging of the eye
    6.
    发明授权
    Spectral bio-imaging of the eye 失效
    眼睛的光谱生物成像

    公开(公告)号：US06276798B1

    公开(公告)日：2001-08-21

    申请号：US09307569

    申请日：1999-05-10

    Applicant: Tamir Gil ,  Dario Cabib ,  Mike Adel ,  Robert A. Buckwald ,  Eli Horn

    Inventor： Tamir Gil ,  Dario Cabib ,  Mike Adel ,  Robert A. Buckwald ,  Eli Horn

    IPC: A61B314

    CPC classification number: A61B5/14546 ,  A61B3/10 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0275 ,  A61B5/1455 ,  A61B5/14555 ,  A61B5/411 ,  A61B5/7257 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/462 ,  G01J3/502 ,  G01J3/51 ,  G01J2003/467

    Abstract: A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color or intensity according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.

    Abstract translation: 一种用于增强眼组织的病理，生理，代谢和健康相关光谱特征的光谱生物成像方法，所述方法包括以下步骤：（a）提供用于眼睛检查的光学装置，光学连接到光谱成像器; （b）通过光圈照射眼组织，通过光学装置和光谱成像器观察眼组织，并为眼组织的每个像素获得光谱; 和（c）根据其光谱特征将每个像素归为颜色或强度，由此提供增强眼组织的光谱特征的图像。

    Film thickness mapping using interferometric spectral imaging
    9.
    发明授权
    Film thickness mapping using interferometric spectral imaging 失效
    使用干涉光谱成像的膜厚度测绘

    公开(公告)号：US5856871A

    公开(公告)日：1999-01-05

    申请号：US776063

    申请日：1997-01-21

    Applicant: Dario Cabib ,  Robert A. Buckwald ,  Michael E. Adel

    Inventor： Dario Cabib ,  Robert A. Buckwald ,  Michael E. Adel

    IPC: C12Q1/68 ,  G01B11/06 ,  G01J3/02 ,  G01J3/26 ,  G01J3/28 ,  G01J3/453 ,  G01N21/64 ,  G01N33/50 ,  G01N33/569 ,  G06K9/00 ,  G06K9/76 ,  G01B9/02

    CPC classification number: G06K9/76 ,  C12Q1/6841 ,  C12Q1/6883 ,  G01B11/0675 ,  G01J3/2823 ,  G01J3/453 ,  G01N33/5005 ,  G01N33/56966 ,  G06K9/00127 ,  G01J2003/2866 ,  G01J3/02 ,  G01J3/26

    Abstract: A method of determining the thickness map of a film (14) overlying a substrate (14). This method includes illuminating (10) the film simultaneously from different angles and analyzing spectral intensity of the radiation reflected by each point on the film (14). The analysis is effected by collecting reflected radiation from the film (14), passing the radiation through an interferometer (16) which outputs modulated radiation corresponding to a predetermined set of linear combinations of the spectral intensity of the radiation emitted from each pixel, simultaneously and separately scanning optical path differences generated in the interferometer (16) for each pixel, focusing the radiation outputted from the interferometer (16) on a detector array, and processing the output of the detector array to determine the spectral intensity of each pixel thereof to obtain a spectral intensity distribution. Finally, the method includes further processing the spectral intensity distribution to determine the spatial distribution of the thickness of the film (16).

    Abstract translation: PCT No.PCT / US95 / 08708 Sec。 371日期1997年1月21日 102（e）日期1997年1月21日PCT提交1995年7月12日PCT公布。 公开号WO96 / 03615 日期1996年2月8日一种确定覆盖衬底（14）的膜（14）的厚度图的方法。 该方法包括从不同角度同时照射（10）胶片并分析由胶片（14）上的每个点反射的辐射的光谱强度。 分析是通过收集来自胶片（14）的反射辐射，使辐射通过干涉仪（16），干涉仪（16）同时输出对应于从每个像素发射的辐射的光谱强度的预定的一组线性组合的调制辐射， 分别扫描针对每个像素的干涉仪（16）中产生的光程差，将从干涉仪（16）输出的辐射聚焦在检测器阵列上，并且处理检测器阵列的输出以确定其每个像素获得的光谱强度 光谱强度分布。 最后，该方法包括进一步处理光谱强度分布以确定薄膜（16）的厚度的空间分布。

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