公开(公告)号：US20140087359A1

公开(公告)日：2014-03-27

申请号：US14033365

申请日：2013-09-20

Applicant: California Institute of Technology

Inventor： Samuel NJOROGE ,  John GORMAN ,  George MALTEZOS ,  Axel SCHERER

IPC: C12M1/00 ,  C12N1/06

CPC classification number: C12M47/06 ,  B01L3/5027 ,  B01L7/52 ,  B01L2300/1883 ,  C12M21/00 ,  C12N1/06 ,  C12N1/066 ,  G01N27/44791

Abstract: Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g., cells, viral particles, etc.). The methods and compositions may comprise a microfluidic chip or use thereof. The microfluidic chips disclosed herein may comprise (a) a substrate comprising a chamber, wherein at least one mechanical element may be located within the chamber; (b) a thermal element in contact with the chamber; and (c) at least one aperture within the surface of the substrate, wherein the aperture may be configured to insulate the chamber.

Abstract translation: 本文公开了用于制备样品的方法和系统。 方法和系统可用于裂解样品中的一种或多种结构（例如，细胞，病毒颗粒等）。 所述方法和组合物可以包含微流控芯片或其用途。 本文公开的微流体芯片可以包括（a）包括腔室的基底，其中至少一个机械元件可以位于腔室内; （b）与所述室接触的热元件; 以及（c）在所述基底表面内的至少一个孔，其中所述孔可以被配置为使所述腔绝缘。

公开(公告)号：US20130130254A1

公开(公告)日：2013-05-23

申请号：US13684020

申请日：2012-11-21

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Samuel NJOROGE ,  Jingqing HUANG

IPC: G01N33/566 ,  A61B5/1459

CPC classification number: G01N33/566 ,  A61B5/1459 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  G01N2201/068 ,  G01N2201/08

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

Abstract translation: 根据本公开的可植入诊断装置提供各种益处，例如紧凑的尺寸，从而允许将装置植入动画物体内; 由于结合廉价的检测电路和使用传统的IC制造技术而导致的低成本; 通过加热可重复使用，从而允许执行多个诊断测试而不丢弃设备; 以及允许同时或不同时间执行同时和/或顺序诊断测试以检测一个或多个相似或不同的靶分子的配置。

公开(公告)号：US20210373013A1

公开(公告)日：2021-12-02

申请号：US17344870

申请日：2021-06-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Samuel NJOROGE ,  Jingqing HUANG

IPC: G01N33/566 ,  A61B5/1459 ,  G01N33/543 ,  G01N21/41 ,  G01N33/552

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US20190195872A1

公开(公告)日：2019-06-27

申请号：US16206294

申请日：2018-11-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Samuel NJOROGE ,  Jingqing HUANG

IPC: G01N33/566 ,  G01N33/543 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/552

CPC classification number: G01N33/566 ,  A61B5/1459 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  G01N2201/068 ,  G01N2201/08

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US20200041508A1

公开(公告)日：2020-02-06

申请号：US16598433

申请日：2019-10-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Samuel NJOROGE ,  Jingqing HUANG

IPC: G01N33/566 ,  A61B5/1459 ,  G01N33/543 ,  G01N21/41 ,  G01N33/552

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US20160258942A1

公开(公告)日：2016-09-08

申请号：US15157346

申请日：2016-05-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Samuel NJOROGE ,  Jingqing HUANG

IPC: G01N33/543 ,  G01N21/41 ,  A61B5/1459 ,  G01N33/552

CPC classification number: G01N33/566 ,  A61B5/1459 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  G01N2201/068 ,  G01N2201/08

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.