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公开(公告)号:US11439926B2
公开(公告)日:2022-09-13
申请号:US16701942
申请日:2019-12-03
Applicant: Cytiva BioProcess R&D AB
Inventor: Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman , Tobias E. Soderman
IPC: C07K1/20 , B01D15/32 , B01J20/285 , B01J20/287 , B01J39/26 , B01J20/28 , B01J20/32 , C07K16/00 , C12N7/00 , G01N1/40
Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.
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公开(公告)号:US20240076650A1
公开(公告)日:2024-03-07
申请号:US18260560
申请日:2022-01-26
Applicant: CYTIVA BIOPROCESS R&D AB
Inventor: Peter Lundback , Ronnie Palmgren , Ola Lind , Nils Norrman , Helen Cheek , Susana Brito Dos Santos , Per Denker
IPC: C12N15/10 , B01D15/38 , B01J20/26 , B01J20/28 , B01J20/289
CPC classification number: C12N15/101 , B01D15/3819 , B01J20/265 , B01J20/28035 , B01J20/28038 , B01J20/289 , B01J2220/52
Abstract: The invention relates to processes for purification of poly-tagged products, such as mRNA, from synthetic or biological compositions. The process involves contacting the composition with a oligo d (T)-functionalized chromatography medium comprising a convection-based chromatography material.
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公开(公告)号:US11014069B2
公开(公告)日:2021-05-25
申请号:US15769400
申请日:2016-10-28
Applicant: Cytiva BioProcess R&D AB
Inventor: Nils Norrman , Mattias Algotsson , Stefan D. Eriksson
Abstract: The present invention relates to a method to improve chromatography beads. More closely, the invention relates to a novel method for production of dextran-containing porous media and chromatography media produced with this method. In the method, the chromatography media is subjected to dextranase-treatment leading to improved pressure-flow properties of the media.
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公开(公告)号:US20220266170A1
公开(公告)日:2022-08-25
申请号:US17741394
申请日:2022-05-10
Applicant: Cytiva BioProcess R&D AB
Inventor: Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman , Tobias E. Soderman
IPC: B01D15/32 , B01J20/285 , B01J20/287 , B01J39/26 , B01J20/28 , B01J20/32 , C07K1/20 , C07K16/00 , C12N7/00 , G01N1/40
Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.
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