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1.发明申请公开(公告)号：US20140319338A1
公开(公告)日：2014-10-30
申请号：US14359853
申请日：2012-11-21
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Bruce A. Thomson , Mircea Guna
CPC classification number: H01J49/0422 , H01J49/044 , H01J49/26
Abstract: A system of mass spectrometry is disclosed having an ion source for generating ions at substantially atmospheric pressure. The system has a sampling member with an orifice disposed therein. The sampling member forms a vacuum chamber with a mass spectrometer. The system also has a curtain plate between the ion source and the sampling member. The curtain plate has an aperture therein, having a cross-section and being spaced from the sampling member to define a flow passage between the curtain plate and the sampling member, and to define an annular gap between the orifice and the aperture. The area of the annular gap is less than the cross-sectional area of the aperture. The system also has a power supply for applying a voltage to the curtain plate, and a curtain gas flow mechanism for directing a curtain gas into the flow passage and the annular gap.
Abstract translation: 公开了一种质谱系统，其具有用于在基本上大气压下产生离子的离子源。 该系统具有设置在其中的孔口的取样构件。 采样构件形成具有质谱仪的真空室。 该系统还在离子源和采样构件之间具有帘板。 帘板在其中具有孔，其具有横截面并且与采样构件间隔开以限定在帘板和采样构件之间的流动通道，并且在孔和孔之间限定环形间隙。 环形间隙的面积小于孔的横截面面积。 该系统还具有用于向帘板施加电压的电源，以及用于将帘式气体引导到流动通道和环形间隙中的帘式气体流动机构。
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公开(公告)号：US10074525B2
公开(公告)日：2018-09-11
申请号：US15026240
申请日：2014-10-07
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Bruce Andrew Collings , Bruce A. Thomson
CPC classification number: H01J49/0045 , H01J49/0063 , H01J49/04 , H01J49/063 , H01J49/40 , H01J49/4215 , H01J49/4225 , H01J49/4285
Abstract: Systems and methods are provided for selecting and fragmenting a first precursor ion in an MS3 experiment. One or more first excitation parameters are calculated that define a first dipole excitation using a processor. The first dipole excitation is used to select a first precursor ion and fragment the first precursor ion to produce a second precursor ion. The first dipole excitation is applied to the continuous beam of ions by sending a first set of data including the first excitation parameters to a mass spectrometer. The first set of data is sent so that a first quadrupole applies the first dipole excitation to a continuous beam of ions. The mass spectrometer includes an ion source that provides the continuous beam of ions and the first quadrupole that receives the continuous beam of ions and is adapted to apply dipole excitation to the continuous beam of ions.
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公开(公告)号：US20140374589A1
公开(公告)日：2014-12-25
申请号：US14375497
申请日：2013-02-01
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Hassan Javaheri , Bruce A. Thomson
CPC classification number: H01J49/063 , H01J49/0031 , H01J49/0445 , H01J49/062 , H01J49/24 , H01J49/26
Abstract: Ions are generated in a high pressure region and are passed into a vacuum chamber having an inlet and an exit aperture. The configuration of the inlet aperture and the pressure difference between the high pressure region and the vacuum chamber provides a supersonic free jet expansion that has a barrel shock of predetermined diameter. At least one ion guide is provided between the inlet and exit apertures having a predetermined cross-section defining an internal volume wherein the cross-section of the at least one ion guide is sized to be at least 50% of the predetermined diameter of the barrel shock of the supersonic free jet expansion. An RF voltage is provided to the at least one ion guide. Radial gas conductance is reduced in a first section of the at least one ion guide for damping shock waves resulting from the supersonic free jet expansion.
Abstract translation: 离子在高压区域产生，并且进入具有入口和出口的真空室。 入口孔的构型和高压区域与真空室之间的压力差提供超音速自由射流膨胀，其具有预定直径的桶形冲击。 至少一个离子导向件设置在入口孔和出口孔之间，其具有限定内部体积的预定横截面，其中至少一个离子导向件的横截面的尺寸被设定为桶的预定直径的至少50％ 超音速自由射流膨胀的冲击。 向至少一个离子导向器提供RF电压。 径向气体导电在至少一个离子导向器的第一部分中减小，用于阻尼由超音速自由射流膨胀产生的冲击波。
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公开(公告)号：US09437410B2
公开(公告)日：2016-09-06
申请号：US14359853
申请日：2012-11-21
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Bruce A. Thomson , Mircea Guna
CPC classification number: H01J49/0422 , H01J49/044 , H01J49/26
Abstract: A system of mass spectrometry is disclosed having an ion source for generating ions at substantially atmospheric pressure. The system has a sampling member with an orifice disposed therein. The sampling member forms a vacuum chamber with a mass spectrometer. The system also has a curtain plate between the ion source and the sampling member. The curtain plate has an aperture therein, having a cross-section and being spaced from the sampling member to define a flow passage between the curtain plate and the sampling member, and to define an annular gap between the orifice and the aperture. The area of the annular gap is less than the cross-sectional area of the aperture. The system also has a power supply for applying a voltage to the curtain plate, and a curtain gas flow mechanism for directing a curtain gas into the flow passage and the annular gap.
Abstract translation: 公开了一种质谱系统，其具有用于在基本上大气压下产生离子的离子源。 该系统具有设置在其中的孔口的取样构件。 采样构件形成具有质谱仪的真空室。 该系统还在离子源和采样构件之间具有帘板。 帘板在其中具有孔，其具有横截面并且与采样构件间隔开以限定在帘板和采样构件之间的流动通道，并且在孔和孔之间限定环形间隙。 环形间隙的面积小于孔的横截面面积。 该系统还具有用于向帘板施加电压的电源，以及用于将帘式气体引导到流动通道和环形间隙中的帘式气体流动机构。
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