公开(公告)号：US10163617B2

公开(公告)日：2018-12-25

申请号：US15026238

申请日：2014-10-07

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bruce Andrew Collings

IPC: H01J49/42 ,  H01J49/00

Abstract: Systems and methods are provided for multiplexed precursor ion selection using a filtered noise field (FNF). Two or more different precursor ions are selected using a processor. The processor calculates an FNF waveform. The calculated FNF waveform is applied to a continuous beam of ions using the processor. The processors sends information to a mass spectrometer, which includes an ion source that provides the continuous beam of ions and a first quadrupole that receives the continuous beam of ions, so that the first quadrupole applies the calculated FNF waveform to the continuous beam of ions. The first quadrupole applies the calculated FNF waveform to the continuous beam of ions by applying the calculated FNF waveform between pairs of rods or between pairs of auxiliary electrodes placed between rods.

公开(公告)号：US20180218895A1

公开(公告)日：2018-08-02

申请号：US15107141

申请日：2014-11-28

Applicant: DH Technologies Development PTE Ltd.

Inventor： Bruce Andrew Collings ,  John Vandermey

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/427 ,  H01J49/0027 ,  H01J49/004 ,  H01J49/4225 ,  H01J49/423

Abstract: A method and apparatus for clearing ions from a multipole ion transmission device which includes introducing a DC or RF clear out pulse to one or more of the rods of the multipole device. The DC pulse is selected so as to supply sufficient kinetic energy to the ions to overcome a pseudo-potential trapping well generated by the RF potentials of the ion transmission device. For an RF pulse, the auxiliary RF signal uses frequencies that correspond to the ejected ion's frequencies of motion. In select embodiments, the multipole device can be a quadrupole or the apparatus can be part of a tandem mass spectrometer.

公开(公告)号：US09991104B2

公开(公告)日：2018-06-05

申请号：US14401030

申请日：2013-04-19

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Bruce Andrew Collings ,  Martian Dima ,  Gordana Ivosev

IPC: H01J49/00 ,  H01J49/02 ,  G01T1/17

CPC classification number: H01J49/0027 ,  G01T1/171 ,  H01J49/0009 ,  H01J49/0036 ,  H01J49/025

Abstract: Systems and methods are provided to perform dead time correction. An observed ion count rate is obtained using a non-paralyzable detection system of a mass spectrometer. The detection system includes an ion detector, a comparator/discriminator, a mono-stable circuit and a counter. The non-paralyzable detection system exhibits dead time extension at high count rates. The extension of the dead time occurs because the mono-stable circuit requires a rising edge to trigger and can only be triggered again after the output pulse from the comparator/discriminator has gone low. This allows a second comparator/discriminator pulse arriving just before the end of the dead time started by a first comparator/discriminator pulse to extend the dead time to the trailing edge of the second comparator/discriminator pulse. A true ion count rate is calculated by performing dead time correction of the observed ion count rate.

公开(公告)号：US20160247671A1

公开(公告)日：2016-08-25

申请号：US15026238

申请日：2014-10-07

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Bruce Andrew Collings

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/4215 ,  H01J49/0031 ,  H01J49/428

Abstract: Systems and methods are provided for multiplexed precursor ion selection using a filtered noise field (FNF). Two or more different precursor ions are selected using a processor. The processor calculates an FNF waveform. The calculated FNF waveform is applied to a continuous beam of ions using the processor. The processors sends information to a mass spectrometer, which includes an ion source that provides the continuous beam of ions and a first quadrupole that receives the continuous beam of ions, so that the first quadrupole applies the calculated FNF waveform to the continuous beam of ions. The first quadrupole applies the calculated FNF waveform to the continuous beam of ions by applying the calculated FNF waveform between pairs of rods or between pairs of auxinary electrodes placed between rods.

Abstract translation: 提供了使用滤波噪声场（FNF）进行多路复用前体离子选择的系统和方法。 使用处理器选择两种或更多种不同的前体离子。 处理器计算FNF波形。 使用处理器将计算的FNF波形应用于连续的离子束。 处理器将信息发送到质谱仪，质谱仪包括提供连续离子束的离子源和接收连续离子束的第一四极杆，使得第一四极杆将计算的FNF波形施加到连续的离子束。 第一个四极杆将计算的FNF波形应用于连续的离子束，通过在棒之间或放置在杆之间的辅助电极对之间施加计算的FNF波形。

公开(公告)号：US20150142361A1

公开(公告)日：2015-05-21

申请号：US14401030

申请日：2013-04-19

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Bruce Andrew Collings ,  Martian Dima ,  Gordana Ivosev

IPC: H01J49/00

CPC classification number: H01J49/0027 ,  G01T1/171 ,  H01J49/0009 ,  H01J49/0036 ,  H01J49/025

Abstract: Systems and methods are provided to perform dead time correction. An observed ion count rate is obtained using a non-paralyzable detection system of a mass spectrometer. The detection system includes an ion detector, a comparator/discriminator, a mono-stable circuit and a counter. The non-paralyzable detection system exhibits dead time extension at high count rates. The extension of the dead time occurs because the mono-stable circuit requires a rising edge to trigger and can only be triggered again after the output pulse from the comparator/discriminator has gone low. This allows a second comparator/discriminator pulse arriving just before the end of the dead time started by a first comparator/discriminator pulse to extend the dead time to the trailing edge of the second comparator/discriminator pulse. A true ion count rate is calculated by performing dead time correction of the observed ion count rate.

Abstract translation: 提供系统和方法来执行死区时间校正。 使用质谱仪的非可分离检测系统获得观察到的离子计数率。 检测系统包括离子检测器，比较器/鉴别器，单稳态电路和计数器。 非可分析检测系统以高计数率显示死区时间延长。 由于单稳态电路需要上升沿触发，只能在比较器/鉴位器的输出脉冲变低后再次触发，才会延长死区时间。 这允许在由第一比较器/鉴频器脉冲开始的死区时间结束之前到达第二比较器/鉴频器脉冲，以将死区时间延长到第二比较器/鉴频器脉冲的后沿。 通过对观察到的离子计数率执行死区时间校正来计算真实的离子计数率。

公开(公告)号：US20150001390A1

公开(公告)日：2015-01-01

申请号：US14373248

申请日：2013-01-16

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bruce Andrew Collings ,  Martian Daniel Dima

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/26

CPC classification number: H01J49/022 ,  H01J49/0027 ,  H01J49/26 ,  H02M1/088 ,  H02M7/103

Abstract: Systems, devices, circuits, and methods are provided for an improved mass spectrometry detection system that comprises an ion source and a detector that operate at opposite polarities. In some embodiments, the system can comprise a positive and negative multiplier, each of which can be configured to provide voltage to each of the ion source and the detector. In some embodiments, the system can comprise switches that allow the change between positive and negative polarities for the ion source or detector to occur quickly. A variety of embodiments of systems, devices, circuits, and methods in conjunction with the disclosures are provided.

Abstract translation: 提供了用于改进的质谱检测系统的系统，装置，电路和方法，其包括以相反极性操作的离子源和检测器。 在一些实施例中，系统可以包括正和负乘法器，其中的每一个可被配置为向离子源和检测器中的每一个提供电压。 在一些实施例中，系统可以包括允许离子源或检测器的正极性和负极性之间的变化快速发生的开关。 提供了结合公开的系统，设备，电路和方法的各种实施例。

公开(公告)号：US10297432B2

公开(公告)日：2019-05-21

申请号：US14380689

申请日：2013-03-15

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Bruce Andrew Collings

IPC: H01J49/00 ,  H01J49/36 ,  H01J49/42

Abstract: Systems and methods are provided to perform sequential windowed acquisition of mass spectrometry data. A mass range and a mass window width parameter are received for a sample. A plurality of ions from the sample that are within the mass range are collected in an ion trap of a mass spectrometer. Two or more mass adjacent or overlapping windows are calculated to span the mass range using the mass window width parameter. Ions within each mass window are ejected from the ion trap. A mass spectrum is then detected from the ejected ions of the each mass window with a mass analyzer of the mass spectrometer, producing a collection of mass spectra for the mass range. The two or more mass windows can all have the same width, can all have different widths, or can have at least two mass windows with different widths.

公开(公告)号：US20180012744A1

公开(公告)日：2018-01-11

申请号：US15544020

申请日：2016-01-29

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bruce Andrew Collings ,  Pascal Martin ,  Stephen Bruce Locke

IPC: H01J49/02 ,  H01J49/00

CPC classification number: H01J49/025 ,  H01J43/24 ,  H01J49/0031

Abstract: An electron multiplier is positioned relative to at least one dynode to direct a beam of secondary particles from the at least one dynode to a collector area of the electron multiplier and not to a channel area of the electron multiplier for a range of electron multiplier voltages applied by one or more voltage sources to the electron multiplier and for a dynode voltage applied by the one or more voltage sources to the at least one dynode. The electron multiplier includes an aperture with an entrance cone and walls of the entrance cone comprise the collector area and an apex of the entrance cone comprises the channel area. An electron multiplier voltage of the range of electron multiplier voltages is applied to the electron multiplier and the dynode voltage is applied to the at least one dynode using the one or more voltage sources.

公开(公告)号：US20150025813A1

公开(公告)日：2015-01-22

申请号：US14380689

申请日：2013-03-15

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Bruce Andrew Collings

IPC: H01J49/00 ,  H01J49/36

CPC classification number: H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/36 ,  H01J49/422

Abstract: Systems and methods are provided to perform sequential windowed acquisition of mass spectrometry data. A mass range and a mass window width parameter are received for a sample. A plurality of ions from the sample that are within the mass range are collected in an ion trap of a mass spectrometer. Two or more mass adjacent or overlapping windows are calculated to span the mass range using the mass window width parameter. Ions within each mass window are ejected from the ion trap. A mass spectrum is then detected from the ejected ions of the each mass window with a mass analyzer of the mass spectrometer, producing a collection of mass spectra for the mass range. The two or more mass windows can all have the same width, can all have different widths, or can have at least two mass windows with different widths.

Abstract translation: 提供系统和方法来执行质谱数据的连续窗口采集。 接收样品的质量范围和质量窗口宽度参数。 在质量范围内的来自样品的多个离子被收集在质谱仪的离子阱中。 使用质量窗宽度参数计算两个或多个质量相邻或重叠的窗口以跨越质量范围。 每个质量窗口内的离子从离子阱排出。 然后用质谱仪的质量分析仪从每个质量窗口的喷射离子中检测质谱，产生质量范围的质谱的集合。 两个或更多个质量窗口都可以具有相同的宽度，都可以具有不同的宽度，或者可以具有至少两个具有不同宽度的质量窗口。

公开(公告)号：US10074529B2

公开(公告)日：2018-09-11

申请号：US15544020

申请日：2016-01-29

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bruce Andrew Collings ,  Pascal Martin ,  Stephen Bruce Locke

IPC: H01J49/02 ,  H01J49/00

Abstract: An electron multiplier is positioned relative to at least one dynode to direct a beam of secondary particles from the at least one dynode to a collector area of the electron multiplier and not to a channel area of the electron multiplier for a range of electron multiplier voltages applied by one or more voltage sources to the electron multiplier and for a dynode voltage applied by the one or more voltage sources to the at least one dynode. The electron multiplier includes an aperture with an entrance cone and walls of the entrance cone comprise the collector area and an apex of the entrance cone comprises the channel area. An electron multiplier voltage of the range of electron multiplier voltages is applied to the electron multiplier and the dynode voltage is applied to the at least one dynode using the one or more voltage sources.