公开(公告)号：US11698582B2

公开(公告)日：2023-07-11

申请号：US16239272

申请日：2019-01-03

Applicant: Exogenesis Corporation

Inventor： Joseph B. Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: H01J37/05 ,  H01J37/317 ,  H01L21/265 ,  H01L21/311 ,  H01L21/02 ,  H05H3/02 ,  G03F1/80 ,  G03F1/82 ,  H01J37/147 ,  H01L29/36 ,  B24B37/04

CPC classification number: G03F1/80 ,  G03F1/82 ,  H01J37/05 ,  H01J37/147 ,  H01J37/317 ,  H01J37/3171 ,  H01L21/02115 ,  H01L21/02274 ,  H01L21/26506 ,  H01L21/26513 ,  H01L21/26566 ,  H01L21/31105 ,  H01L21/31111 ,  H05H3/02 ,  B24B37/04 ,  H01J2237/0041 ,  H01J2237/0812 ,  H01J2237/15 ,  H01L29/36 ,  Y10T428/24355 ,  Y10T428/24479 ,  Y10T428/30

Abstract: A method for preparing a biological material for implanting provides irradiating at least a portion of the surface of the material with an accelerated Neutral Beam.

公开(公告)号：US20190336657A1

公开(公告)日：2019-11-07

申请号：US16502696

申请日：2019-07-03

Applicant: Exogenesis Corporation

Inventor： Richard C. Svrluga ,  Sean R. Kirkpatrick ,  Stephen M. Blinn

IPC: A61L31/16 ,  A61K31/436 ,  A61L27/54

Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.

公开(公告)号：US09799488B2

公开(公告)日：2017-10-24

申请号：US14571533

申请日：2014-12-16

Applicant: Exogenesis Corporation

Inventor： Sean R. Kirkpatrick ,  Allen R. Kirkpatrick ,  Michael J. Walsh ,  Richard C. Svrluga

IPC: H01J37/05 ,  H01J37/317 ,  H01J37/08 ,  H01J37/147

CPC classification number: H01J37/3171 ,  C03C23/005 ,  C03C2204/08 ,  H01J37/05 ,  H01J37/08 ,  H01J37/147 ,  H01J37/317 ,  H01J2237/0041 ,  H01J2237/0812 ,  H01J2237/15 ,  H01J2237/31701 ,  H01L21/02115 ,  H01L21/02238 ,  H01L21/02274 ,  H01L21/26506 ,  H01L21/26513 ,  H01L21/26566 ,  H01L21/31105 ,  H01L21/31116 ,  H01L21/32115 ,  H01L29/36 ,  H01M4/04 ,  H01M10/04 ,  H01M10/0585 ,  H01M2004/021 ,  Y10T428/24355 ,  Y10T428/24479 ,  Y10T428/30

Abstract: A method of improving the surface of an object treats the surface with a neutral beam formed from a gas cluster ion mean to create a surface texture and/or increase surface area.

公开(公告)号：US20150038899A1

公开(公告)日：2015-02-05

申请号：US14238503

申请日：2012-08-22

Applicant: EXOGENESIS CORPORATION

Inventor： Laurence B. Tarrant ,  Richard C. Svrluga ,  Sean R. Kirkpatrick

IPC: A61F2/30 ,  A61C8/00 ,  A61L31/16 ,  B05D3/06 ,  A61L31/08 ,  A61C19/06 ,  A61F2/36

CPC classification number: A61F2/30771 ,  A61C8/0013 ,  A61C19/06 ,  A61F2/30942 ,  A61F2/3607 ,  A61F2002/2835 ,  A61F2002/30028 ,  A61F2002/3068 ,  A61L27/047 ,  A61L27/06 ,  A61L27/306 ,  A61L27/32 ,  A61L27/50 ,  A61L27/54 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2430/02 ,  B05D3/068

Abstract: A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of accelerated Neutral Beam irradiation, wherein the Neutral Beam is derived from an accelerated gas cluster ion beam irradiation for improving bone integration.

Abstract translation: 由生物相容性材料（优选包含二氧化钛或氧化锆）制成的骨可植入医疗装置具有至少部分其表面改性以便于改进与骨的整合。 可植入装置可以包含注入骨诱导剂的表面和/或可以掺入装有治疗剂的孔。 输注的表面和/或孔可以被图案化以确定引入的骨诱导剂和/或治疗剂的分布和量。 可以控制治疗剂的释放或洗脱曲线的速率。 还公开了用于生产这种骨可植入医疗装置的方法，并且采用加速中性束照射的方法，其中中性束源自用于改善骨整合的加速气体簇离子束照射。

公开(公告)号：US11004692B2

公开(公告)日：2021-05-11

申请号：US15758436

申请日：2016-07-22

Applicant: Exogenesis Corporation

Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: H01L21/311 ,  H01L21/3213 ,  C03C15/02 ,  H01L21/02 ,  H01L21/306 ,  H01L21/3065 ,  H01L21/3105 ,  C03C15/00 ,  H01L21/265 ,  H01L21/308

Abstract: A method for shallow etching a substrate surface forms a shallow modified substrate layer overlying unmodified substrate using an accelerated neutral beam and etches the modified layer, stopping at the unmodified substrate beneath, producing controlled shallow etched substrate surfaces.

公开(公告)号：US20180247831A1

公开(公告)日：2018-08-30

申请号：US15758436

申请日：2016-07-22

Applicant: Exogenesis Corporation

Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: H01L21/3213 ,  H01L21/02 ,  H01L21/306 ,  H01L21/3065 ,  H01L21/308 ,  H01L21/311 ,  C03C15/02

CPC classification number: H01L21/32134 ,  C03C15/00 ,  C03C15/025 ,  H01J2237/061 ,  H01J2237/0812 ,  H01L21/02115 ,  H01L21/02167 ,  H01L21/02227 ,  H01L21/02238 ,  H01L21/02252 ,  H01L21/02274 ,  H01L21/02326 ,  H01L21/0234 ,  H01L21/26566 ,  H01L21/30604 ,  H01L21/3065 ,  H01L21/3086 ,  H01L21/3105 ,  H01L21/31105 ,  H01L21/31111 ,  H01L21/31116

Abstract: A method for shallow etching a substrate surface forms a shallow modified substrate layer overlying unmodified substrate using an accelerated neutral beam and etches the modified layer, stopping at the unmodified substrate beneath, producing controlled shallow etched substrate surfaces.

公开(公告)号：US20180211813A1

公开(公告)日：2018-07-26

申请号：US15933121

申请日：2018-03-22

Applicant: Exogenesis Corporation

Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: H01J37/05 ,  H05H3/02 ,  H01J37/317 ,  H01J37/147

CPC classification number: H01J37/05 ,  A61F2/82 ,  A61F2/90 ,  A61F2240/001 ,  A61F2250/0068 ,  H01J37/147 ,  H01J37/317 ,  H01J37/3171 ,  H01J2237/0041 ,  H01J2237/0812 ,  H01J2237/15 ,  H05H3/02 ,  Y10T428/24355 ,  Y10T428/24479 ,  Y10T428/30

Abstract: A medical device for surgical implantation adapted to serve as a drug delivery system has one or more drug loaded holes with barrier layers to control release or elution of the drug from the holes or to control inward diffusion of fluids into the holes. The barrier layers are non-polymers and are formed from the drug material itself by beam processing. The holes may be in patterns to spatially control drug delivery. Flexible options permit combinations of drugs, variable drug dose per hole, multiple drugs per hole, temporal control of drug release sequence and profile. Methods for forming such a drug delivery system are also disclosed. Gas cluster ion beam and/or accelerated Neutral Beam derived from an accelerated gas cluster ion beam may be employed.

公开(公告)号：US20130138213A1

公开(公告)日：2013-05-30

申请号：US13746795

申请日：2013-01-22

Applicant: EXOGENESIS CORPORATION

Inventor： Richard C. Svrluga ,  Laurence B. Tarrant ,  Stephen M. Blinn

IPC: C23C14/22 ,  A61F2/28

CPC classification number: A61F2/28 ,  A61C8/0012 ,  A61C8/0018 ,  A61F2/30771 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/30795 ,  A61F2250/0068 ,  A61F2310/00796 ,  A61L27/10 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2400/18 ,  B05D3/068 ,  C23C14/221 ,  C23C14/48

Abstract: A method of modifying a surface of implantable medical device provides coating at least a first portion of the surface of the medical device with a therapeutic agent to form a coated surface region; and irradiating at least a portion of the coated surface region with a gas cluster ion beam infusing the therapeutic agent into the at least a portion of the coated surface region.

Abstract translation: 修改可植入医疗装置的表面的方法提供用医疗装置的表面的至少第一部分涂覆治疗剂以形成涂覆的表面区域; 以及将所述涂覆的表面区域的至少一部分用喷射所述治疗剂的气体团簇离子束照射到所述涂覆的表面区域的至少一部分中。

公开(公告)号：US20190171098A1

公开(公告)日：2019-06-06

申请号：US16273013

申请日：2019-02-11

Applicant: Exogenesis Corporation

Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga ,  Stephen M. Blinn

IPC: G03F1/80 ,  H01L21/265 ,  H01J37/05 ,  H01J37/317 ,  H01L21/311 ,  H01L21/02 ,  G03F1/82 ,  H05H3/02 ,  H01J37/147

Abstract: An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate.

公开(公告)号：US09795719B2

公开(公告)日：2017-10-24

申请号：US14985825

申请日：2015-12-31

Applicant: Exogenesis Corporation

Inventor： Stephen M. Blinn ,  Richard C. Svrluga

IPC: A61L31/16 ,  A61L31/12 ,  A61F2/82 ,  C23C14/02 ,  C23C14/22 ,  C23C14/50

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2250/0067 ,  A61L31/12 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/426 ,  A61L2300/61 ,  A61L2300/62 ,  A61L2400/18 ,  C23C14/022 ,  C23C14/221 ,  C23C14/505 ,  H01J2237/0812 ,  Y10T428/249988 ,  Y10T428/31504

Abstract: In one embodiment, a drug delivery system and method provide a member including a combination of a drug substance and a polymer or other material, and an encapsulating layer formed in an outer surface of the member by gas cluster ion beam irradiation of the outer surface of the member, which encapsulating layer is adapted to determine one or more characteristics of the drug delivery system.