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公开(公告)号：US10744039B2
公开(公告)日：2020-08-18
申请号：US15790851
申请日：2017-10-23
Applicant: Ension, Inc.
Inventor： Ali Hussain , Patrick Cahalan , Linda Cahalan
IPC: A61F13/00 , C07K14/78 , A61L15/32 , A61L15/42 , A61L27/20 , B32B5/10 , A61K38/39 , A61L27/24 , A61L31/14 , A61L31/04
Abstract: A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.
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公开(公告)号：US11622892B2
公开(公告)日：2023-04-11
申请号：US16995771
申请日：2020-08-17
Applicant: Ension, Inc.
Inventor： Ali Hussain , Patrick Cahalan , Linda Cahalan
IPC: A61F13/00 , C07K14/78 , A61L15/32 , A61L15/42 , A61L27/20 , B32B5/10 , A61K38/39 , A61L27/24 , A61L31/14 , A61L31/04
Abstract: A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.
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公开(公告)号：US10456227B2
公开(公告)日：2019-10-29
申请号：US15640873
申请日：2017-07-03
Applicant: Ension, Inc.
Inventor： Ali Hussain , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J Fill , Jeffrey W. Speakman
IPC: A61C15/04 , A61B17/06 , A61B17/064 , A61L31/04 , A61L31/10 , A61L33/00 , B05D3/06 , A61M1/16 , B05D7/02 , B05D1/36 , B05D1/00
Abstract: A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.
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公开(公告)号：US20180064580A1
公开(公告)日：2018-03-08
申请号：US15790851
申请日：2017-10-23
Applicant: Ension, Inc.
Inventor： Ali HUSSAIN , Patrick Cahalan , Linda Cahalan
CPC classification number: A61F13/00012 , A61F13/00029 , A61F2013/00604 , A61K38/39 , A61L15/325 , A61L15/425 , A61L27/20 , A61L27/24 , A61L31/044 , A61L31/146 , B32B5/10 , B32B2250/20 , C07K14/78
Abstract: A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.
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公开(公告)号：US10512465B2
公开(公告)日：2019-12-24
申请号：US15450327
申请日：2017-03-06
Applicant: Ension, Inc.
Inventor： Mark J Gartner , Patrick Cahalan , Linda Cahalan
Abstract: An apparatus for stimulation of collateral development in ischemic cardiac regions comprises a mechanism for fluid coupling of the left ventricle of the heart to the anterior interventricular vein to stimulate collateral development in ischemic regions. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes a control of the diastolic/systolic pressure in the venous system to be within about 20-50 mmHg. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes inserting a transmyocardial conduit into the left ventricle and a tri-directional coupler attached to the anterior interventricular vein. An associated method for stimulation of collateral development in ischemic cardiac regions via the fluid coupling of the left ventricle of the heart to the anterior interventricular vein is disclosed.
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Patent Agency Ranking
公开(公告)号：US20180125620A1
公开(公告)日：2018-05-10
申请号：US15640873
申请日：2017-07-03
Applicant: Ension, Inc.
Inventor： Ali Hussain , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J. Fill , Jeffrey W. Speakman
CPC classification number: A61C15/041 , A61B17/06 , A61B17/06166 , A61B17/064 , A61L31/048 , A61L31/10 , A61L33/0029 , A61L2400/18 , A61M1/1698 , B05D1/36 , B05D1/62 , B05D3/06 , B05D7/02 , B05D2256/00 , B05D2258/00 , C08L83/04 , C08L23/12
Abstract: A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.
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7.发明授权公开(公告)号：US09585665B2
公开(公告)日：2017-03-07
申请号：US14452403
申请日：2014-08-05
Applicant: Ension, Inc.
Inventor： Mark J Gartner , Patrick Cahalan , Linda Cahalan
CPC classification number: A61N1/00 , A61B17/00234 , A61B17/11 , A61B18/14 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135 , A61B2018/00053 , A61F2/064 , A61N1/05 , A61N1/056 , A61N1/057
Abstract: A method for stimulation of collateral development in ischemic cardiac regions comprises the fluid coupling of the left ventricle of the heart to the anterior interventricular vein to stimulate collateral development in ischemic regions. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes a control of the diastolic/systolic pressure in the venous system to be within about 20-50 mmHg. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes inserting a transmyocardial conduit into the left ventricle and a tri-directional coupler attached to the anterior interventricular vein. An associated apparatus for stimulation of collateral development in ischemic cardiac regions via the fluid coupling of the left ventricle of the heart to the anterior interventricular vein is disclosed.
Abstract translation: 用于刺激缺血性心脏区域中侧支发育的方法包括心脏左心室与前室间静脉的流体耦合以刺激缺血区域中的旁路发育。 心脏左心室与前室间静脉的流体耦合包括将静脉系统的舒张/收缩压控制在约20-50mmHg内。 心脏左心室与前室间静脉的流体耦合包括将心肌导管插入左心室和连接到前室间静脉的三向耦合器。 公开了一种用于通过心脏左心室与前室间静脉的流体耦合来刺激缺血性心脏区域中侧支发育的相关装置。
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8.发明申请公开(公告)号：US20150038999A1
公开(公告)日：2015-02-05
申请号：US14452403
申请日：2014-08-05
Applicant: Ension, Inc.
Inventor： Mark J Gartner , Patrick Cahalan , Linda Cahalan
IPC: A61B17/11
CPC classification number: A61N1/00 , A61B17/00234 , A61B17/11 , A61B18/14 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135 , A61B2018/00053 , A61F2/064 , A61N1/05 , A61N1/056 , A61N1/057
Abstract: A method for stimulation of collateral development in ischemic cardiac regions comprises the fluid coupling of the left ventricle of the heart to the anterior interventricular vein to stimulate collateral development in ischemic regions. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes a control of the diastolic/systolic pressure in the venous system to be within about 20-50 mmHg. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes inserting a transmyocardial conduit into the left ventricle and a tri-directional coupler attached to the anterior interventricular vein. An associated apparatus for stimulation of collateral development in ischemic cardiac regions via the fluid coupling of the left ventricle of the heart to the anterior interventricular vein is disclosed.
Abstract translation: 用于刺激缺血性心脏区域中侧支发育的方法包括心脏左心室与前室间静脉的流体耦合以刺激缺血区域中的旁路发育。 心脏左心室与前室间静脉的流体耦合包括将静脉系统的舒张/收缩压控制在约20-50mmHg内。 心脏左心室与前室间静脉的流体耦合包括将心肌导管插入左心室和连接到前室间静脉的三向耦合器。 公开了一种用于通过心脏左心室与前室间静脉的流体耦合来刺激缺血性心脏区域中侧支发育的相关装置。
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公开(公告)号：US20220196532A1
公开(公告)日：2022-06-23
申请号：US17451315
申请日：2021-10-18
Applicant: Ension, Inc.
Inventor： Linda Cahalan , Patrick Cahalan , Michael Hegy
Abstract: A flow-based biological testing platform comprises a stationary base; a reciprocating base mounted on the stationary base, configured for reciprocating motion on the base; and at least one flexible tubular test loop coupled to both the stationary and the reciprocating base, wherein each test loop is configured to be selectively filled with a biologic fluid, and wherein each test loop includes at least one check valve mounted within the test loop allowing flow in a single flow direction within the test loop, and a fluid loading and removal system attached to the stationary base allowing fluid to be supplied to and withdrawn from the flexible tubular test loop; wherein reciprocation of the reciprocating base induces fluid flow in a single direction within each flexible test loop.
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公开(公告)号：US09796769B2
公开(公告)日：2017-10-24
申请号：US14041372
申请日：2013-09-30
Applicant: Ension, Inc.
Inventor： Ali Hussain , Patrick Cahalan , Linda Cahalan
CPC classification number: C07K14/78 , A61L15/325 , A61L15/425 , A61L31/044 , A61L31/146
Abstract: A method of preparing a crosslinked, collagen-based medical scaffold is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for wound care dressings, hernia repair prosthetics, and surgical incision closure members, prepared using the method above.
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