公开(公告)号：US10058889B2

公开(公告)日：2018-08-28

申请号：US14774318

申请日：2014-03-10

Applicant: Kettering University

Inventor： Mary Gilliam ,  Susan Farhat ,  Ali Zand

IPC: B05D1/00 ,  B05D3/14 ,  A61L27/16 ,  A61L27/34 ,  C08L33/12 ,  A61L31/10 ,  B05D1/02

CPC classification number: B05D1/62 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/02 ,  B05D1/02 ,  B05D3/144 ,  B05D3/147 ,  B05D3/148 ,  C08L33/12

Abstract: A method of forming a biocompatible or biologically inert article for use in an application in which the article will make contact with at least one tissue, organ, or fluid within a human or animal body is provided. The method generally comprises providing an article having an external surface; selecting chemical precursors; using a means to direct one or more chemical precursors towards or to apply such chemical precursors to the external surface; activating the chemical precursors by exposing said precursors to atmospheric pressure plasma; and grafting and/or cross-linking the chemical precursors to form a solid coating adjacent to the external surface of the article.

公开(公告)号：US20160023240A1

公开(公告)日：2016-01-28

申请号：US14774318

申请日：2014-03-10

Applicant: KETTERING UNIVERSITY

Inventor： Mary Gilliam ,  Susan Farhat ,  Ali Zand

IPC: B05D1/00 ,  B05D3/14 ,  A61L31/10 ,  B05D1/02

CPC classification number: B05D1/62 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/02 ,  B05D1/02 ,  B05D3/144 ,  B05D3/147 ,  B05D3/148 ,  C08L33/12

Abstract: A method of forming a biocompatible or biologically inert article for use in an application in which the article will make contact with at least one tissue, organ, or fluid within a human or animal body is provided. The method generally comprises providing an article having an external surface; selecting chemical precursors; using a means to direct one or more chemical precursors towards or to apply such chemical precursors to the external surface; activating the chemical precursors by exposing said precursors to atmospheric pressure plasma; and grafting and/or cross-linking the chemical precursors to form a solid coating adjacent to the external surface of the article.

Abstract translation: 提供一种形成用于制品将与人或动物体内的至少一种组织，器官或流体接触的应用中的生物相容性或生物惰性制品的方法。 该方法通常包括提供具有外表面的制品; 选择化学前体; 使用一种方法将一种或多种化学前体引导到或将这种化学前体施用于外表面; 通过将所述前体暴露于大气压等离子体来活化化学前体; 和接枝和/或交联化学前体以形成邻近制品外表面的固体涂层。