公开(公告)号：US20160023240A1

公开(公告)日：2016-01-28

申请号：US14774318

申请日：2014-03-10

Applicant: KETTERING UNIVERSITY

Inventor： Mary Gilliam ,  Susan Farhat ,  Ali Zand

IPC: B05D1/00 ,  B05D3/14 ,  A61L31/10 ,  B05D1/02

CPC classification number: B05D1/62 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/02 ,  B05D1/02 ,  B05D3/144 ,  B05D3/147 ,  B05D3/148 ,  C08L33/12

Abstract: A method of forming a biocompatible or biologically inert article for use in an application in which the article will make contact with at least one tissue, organ, or fluid within a human or animal body is provided. The method generally comprises providing an article having an external surface; selecting chemical precursors; using a means to direct one or more chemical precursors towards or to apply such chemical precursors to the external surface; activating the chemical precursors by exposing said precursors to atmospheric pressure plasma; and grafting and/or cross-linking the chemical precursors to form a solid coating adjacent to the external surface of the article.

Abstract translation: 提供一种形成用于制品将与人或动物体内的至少一种组织，器官或流体接触的应用中的生物相容性或生物惰性制品的方法。 该方法通常包括提供具有外表面的制品; 选择化学前体; 使用一种方法将一种或多种化学前体引导到或将这种化学前体施用于外表面; 通过将所述前体暴露于大气压等离子体来活化化学前体; 和接枝和/或交联化学前体以形成邻近制品外表面的固体涂层。

公开(公告)号：US20160039979A1

公开(公告)日：2016-02-11

申请号：US14776078

申请日：2014-03-14

Applicant: KETTERING UNIVERSITY

Inventor： Mary Gilliam ,  Susan Farhat ,  Graham Garner ,  Michael Magyar

IPC: C08J3/24

CPC classification number: C08J3/24 ,  C08J3/124 ,  C08J2323/12 ,  C08J2327/18 ,  C08J2333/12

Abstract: A method and apparatus is provided for the modification of the surface chemistry of solid nano- and micro-particles in order to tailor the properties and functions of these particles. The method generally involves the generation of an atmospheric plasma glow discharge and energetic species that undergo chemical reaction with the surface of the primary particles. The process includes the generation of energetic species to initiate reaction, optional delivery of a precursor fluid, optional delivery of chemical species for grafting, and delivery of separated and de-agglomerated particles into the plasma discharge exiting the plasma generation chamber.

Abstract translation: 提供了一种方法和装置，用于修饰固体纳米和微粒的表面化学性质，以便调整这些颗粒的性质和功能。 该方法通常涉及产生大气等离子体辉光放电和与初级粒子的表面进行化学反应的能量物质。 该方法包括产生能量物质以引发反应，任选的前体流体递送，用于接枝的化学物质的任选递送以及离开等离子体产生室的等离子体放电中分离和去结块的颗粒的输送。

公开(公告)号：US10058889B2

公开(公告)日：2018-08-28

申请号：US14774318

申请日：2014-03-10

Applicant: Kettering University

Inventor： Mary Gilliam ,  Susan Farhat ,  Ali Zand

IPC: B05D1/00 ,  B05D3/14 ,  A61L27/16 ,  A61L27/34 ,  C08L33/12 ,  A61L31/10 ,  B05D1/02

CPC classification number: B05D1/62 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/02 ,  B05D1/02 ,  B05D3/144 ,  B05D3/147 ,  B05D3/148 ,  C08L33/12

Abstract: A method of forming a biocompatible or biologically inert article for use in an application in which the article will make contact with at least one tissue, organ, or fluid within a human or animal body is provided. The method generally comprises providing an article having an external surface; selecting chemical precursors; using a means to direct one or more chemical precursors towards or to apply such chemical precursors to the external surface; activating the chemical precursors by exposing said precursors to atmospheric pressure plasma; and grafting and/or cross-linking the chemical precursors to form a solid coating adjacent to the external surface of the article.

公开(公告)号：US09994683B2

公开(公告)日：2018-06-12

申请号：US14776078

申请日：2014-03-14

Applicant: Kettering University

Inventor： Mary Gilliam ,  Susan Farhat ,  Graham Garner ,  Michael Magyar

IPC: C08J3/24 ,  C08J3/12

CPC classification number: C08J3/24 ,  C08J3/124 ,  C08J2323/12 ,  C08J2327/18 ,  C08J2333/12

Abstract: A method and apparatus is provided for the modification of the surface chemistry of solid nano- and micro-particles in order to tailor the properties and functions of these particles. The method generally involves the generation of an atmospheric plasma glow discharge and energetic species that undergo chemical reaction with the surface of the primary particles. The process includes the generation of energetic species to initiate reaction, optional delivery of a precursor fluid, optional delivery of chemical species for grafting, and delivery of separated and de-agglomerated particles into the plasma discharge exiting the plasma generation chamber.