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    SYSTEM AND METHOD FOR THE ACOUSTIC LOADING OF AN ANALYTICAL INSTRUMENT USING A CONTINUOUS FLOW SAMPLING PROBE
    6.
    发明申请
    SYSTEM AND METHOD FOR THE ACOUSTIC LOADING OF AN ANALYTICAL INSTRUMENT USING A CONTINUOUS FLOW SAMPLING PROBE 有权

    公开(公告)号：US20210090867A1

    公开(公告)日：2021-03-25

    申请号：US16985076

    申请日：2020-08-04

    Applicant: Labcyte, Inc. ,  DH Technologies Development Pte. Ltd.

    Inventor： Sammy Datwani ,  Don W. Arnold ,  Lucien P. Ghislain ,  Chang Liu ,  Thomas Covey

    IPC: H01J49/04 ,  H01J49/16 ,  H01J49/00 ,  B01L3/02

    Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.

    System and method for the acoustic loading of an analytical instrument using a continuous flow sampling probe
    10.
    发明授权
    System and method for the acoustic loading of an analytical instrument using a continuous flow sampling probe 有权

    公开(公告)号：US12154776B2

    公开(公告)日：2024-11-26

    申请号：US18121550

    申请日：2023-03-14

    Applicant: LABCYTE INC. ,  DH Technologies Development Pte. Ltd.

    Inventor： Sammy Datwani ,  Don W. Arnold ,  Lucien P. Ghislain ,  Chang Liu ,  Thomas Covey

    IPC: H01J49/04 ,  B01L3/02 ,  G01N29/02 ,  G01N29/22 ,  H01J49/00 ,  H01J49/16

    Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.

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