公开(公告)号：US20170140910A1

公开(公告)日：2017-05-18

申请号：US15361968

申请日：2016-11-28

Applicant: Micromass UK Limited

Inventor： Jeffery Mark BROWN ,  Kevin GILES ,  Daniel James KENNY ,  Paul MURRAY ,  Keith RICHARDSON

IPC: H01J49/00 ,  G01N27/62

CPC classification number: H01J49/0059 ,  G01N27/624 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/26 ,  H01J49/40 ,  H01J49/422 ,  H01J49/4245

Abstract: A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.

公开(公告)号：US20170200595A1

公开(公告)日：2017-07-13

申请号：US15412595

申请日：2017-01-23

Applicant: Micromass UK Limited

Inventor： Kevin GILES ,  Jason Lee WILDGOOSE

IPC: H01J49/00 ,  H01J49/36 ,  H01J49/06

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/062 ,  H01J49/065 ,  H01J49/36 ,  H01J49/4235

Abstract: An ion mobility separator and a method of separating ions according to their ion mobility are disclosed. An RF ion guide is provided having a plurality of electrodes that are arranged to form an ion guiding path that extends in a closed loop. RF voltages are supplied to at least some of the electrodes in order to confine ions within said ion guiding path. A DC voltage gradient is maintained along at least a portion of a longitudinal axis of the ion guide, wherein the voltage gradient urges ions to undergo one or more cycles around the ion guide and thus causes the ions to separate according to their ion mobility as the ions pass along the ion guide. The closed loop ion guide enables the resolution of the ion mobility separator to be increased without necessitating a large device, since the drift length through the device can be increased by causing the ions to undergo multiple cycles around the device.

公开(公告)号：US20170110303A1

公开(公告)日：2017-04-20

申请号：US15312399

申请日：2015-05-29

Applicant: MICROMASS UK LIMITED

Inventor： Kevin GILES ,  Jason Lee WILDGOOSE

IPC: H01J49/00 ,  G01N27/62

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/004 ,  H01J49/0045

Abstract: A method of analysing ions is disclosed comprising performing an initial multi-dimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating the parent ions according to a second physico-chemical property. At least one parent ion of interest from the initial multi-dimensional survey scan is determined, the at least one parent ion of interest having a first value or range of the first physico-chemical property and a second value or range of the second physico-chemical property. Then, during a subsequent single cycle of separation, the method further comprises separating parent ions according to the first physico-chemical property. If the parent ions have a value or range of the first physico-chemical property which corresponds with the first value or range, then the method further comprises selecting parent ions of interest having a value or range of the first physico-chemical property which corresponds with the first value or range and which also have a value or range of the second physico-chemical property which corresponds with the second value or range. If the parent ions have a value or range of the first physico-chemical property which does not correspond with the first value or range then the method further comprises separating the parent ions according to the first physico-chemical property and separating the parent ions according to the second physico-chemical property.

公开(公告)号：US20170263425A1

公开(公告)日：2017-09-14

申请号：US15417672

申请日：2017-01-27

Applicant: Micromass UK Limited

Inventor： Kevin GILES ,  Jason Lee WILDGOOSE

IPC: H01J49/00 ,  H01J49/40 ,  G01N27/62

CPC classification number: H01J49/0031 ,  G01N27/624 ,  G01N30/72 ,  H01J49/004 ,  H01J49/40

Abstract: A method of analysing ions is disclosed comprising performing an initial multi-dimensional survey scan comprising separating parent ions according to a first physico-chemical property (e.g. ion mobility) and then separating the parent ions according to a second physico-chemical property (e.g. mass to charge ratio). A plurality of parent ions of interest are then determined from the initial multi-dimensional survey scan. Once parent ions of interest have been determined, the plurality of parent ions of interest are sequentially selected based upon the first and second physico-chemical properties during a single cycle of separation. The parent ions of interest may then be fragmented and corresponding fragment ions may then be mass analysed.

公开(公告)号：US20170200594A1

公开(公告)日：2017-07-13

申请号：US15314359

申请日：2015-05-29

Applicant: Micromass UK Limited

Inventor： Kevin GILES ,  David J. LANGRIDGE ,  Steven Derek PRINGLE ,  Keith RICHARDSON ,  Jason Lee WILDGOOSE

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/40 ,  G01N27/62

CPC classification number: H01J49/004 ,  G01N27/622 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/066 ,  H01J49/067 ,  H01J49/40

Abstract: A method of mass spectrometry is disclosed comprising separating ions temporally in a first device and analysing the mass or mass to charge ratio of the ions or of product or fragment ions derived from the ions in a mass or mass to charge ratio analyser disposed downstream of the first device. The method further comprises obtaining a first set of drift times for the ions through the first device by measuring ion arrival times and determining the transit time of the ions and/or of the product or fragment ions through one or more intermediate regions or devices disposed between the first device and the mass to charge ratio analyser. The method further comprises obtaining a second set of drift times for the ions through the first device by correcting the first set of drift times to account for the determined transit times.

公开(公告)号：US20170092477A1

公开(公告)日：2017-03-30

申请号：US15278347

申请日：2016-09-28

Applicant: Micromass UK Limited

Inventor： Kevin GILES ,  David GORDON

IPC: H01J49/06 ,  H01J49/00

CPC classification number: H01J49/062 ,  H01J49/0027

Abstract: An ion guide comprises a first ion guide portion that forms a first ion guiding path and a second ion guide portion that forms a second ion guiding path. A first device applies a plurality of different first voltages or potentials to the electrodes of the first ion guide portion in order to generate an electric field that directs ions from the first ion guiding path of the first ion guide portion into the second ion guiding path of the second ion guide portion. The use of plural different first voltages can provide a controlled transfer of ions from the first ion guiding path into the second ion guiding path.

公开(公告)号：US20170076929A1

公开(公告)日：2017-03-16

申请号：US15310694

申请日：2015-05-13

Applicant: MICROMASS UK LIMITED

Inventor： Kevin GILES ,  Jason Lee WILDGOOSE

IPC: H01J49/06 ,  H01J49/40 ,  H01J49/00

CPC classification number: H01J49/065 ,  H01J49/0027 ,  H01J49/004 ,  H01J49/40

Abstract: A method of mass spectrometry is disclosed comprising separating first ions according to a first physico-chemical property in a first separator wherein at least some of the first ions undergo a different number of cycles or passes within the separator and separating the first ions which emerge from the first separator according to a second physico-chemical property wherein the second physico-chemical property is correlated with the first physico-chemical property. The method further comprises determining the second physico-chemical property of the first ions and determining, assigning or de-convolving the first physico-chemical property of the first ions based upon the determined second physico-chemical property of the first ions.

Abstract translation: 公开了一种质谱法，其包括根据第一分离器中的第一物理化学性质分离第一离子，其中至少一些第一离子在分离器内经历不同数量的循环或通过，并分离出从 根据第二物理化学性质的第一分离器，其中第二物理化学性质与第一物理化学性质相关。 该方法还包括确定第一离子的第二物理化学性质，并基于所确定的第一离子的第二物理化学性质确定，分配或去卷积第一离子的第一物理化学性质。

公开(公告)号：US20170345637A1

公开(公告)日：2017-11-30

申请号：US15603593

申请日：2017-05-24

Applicant: Micromass UK Limited

Inventor： Martin Raymond GREEN ,  Kevin GILES ,  David J. LANGRIDGE

IPC: H01J49/42

CPC classification number: H01J49/4225 ,  H01J49/4265

Abstract: An ion trapping system is disclosed comprising an ion urging system for urging ions to spread out within an ion trapping region. Alternatively, the ion trapping system may deflect ions such that ions enter the ion trapping region at different locations. Alternatively, an ion deflector may be arranged upstream of, or at the entrance to, the ion trapping region, for deflecting ions such that ions enter the ion trapping region with different speeds so that the ions spread out within the ion trapping region.

公开(公告)号：US20170184547A1

公开(公告)日：2017-06-29

申请号：US15376216

申请日：2016-12-12

Applicant: Micromass UK Limited

Inventor： Robert Harold BATEMAN ,  Kevin GILES ,  Steven Derek PRINGLE ,  Jason Lee WILDGOOSE

IPC: G01N27/62 ,  H01J49/06 ,  H01J49/00

CPC classification number: G01N27/622 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/062

Abstract: A mass spectrometer is disclosed comprising a first ion trap or ion guide, a single ion mobility spectrometer or separator stage and a second ion trap or ion guide arranged downstream of the ion mobility spectrometer or separator. In a mode of operation ions from the second ion trap or ion guide are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator.

公开(公告)号：US20170140908A1

公开(公告)日：2017-05-18

申请号：US15317045

申请日：2015-06-11

Applicant: Micromass UK Limited

Inventor： Kevin GILES ,  Martin Raymond GREEN ,  Steven Derek PRINGLE ,  Keith RICHARDSON ,  Jason Lee WILDGOOSE

IPC: H01J49/00 ,  G01N27/62

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0045

Abstract: A method of analysing ions, comprising performing an initial multidimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating said parent ions according to a second physico-chemical property, producing a two-dimensional data set comprising data corresponding to said first physico-chemical property and data corresponding to said second physico-chemical property, identifying one or more target ion species of interest and determining a mode of operation of a mass spectrometer for said target ion species of interest using data relating to said target ion species of interest in said two-dimensional data set, wherein said mode of operation comprises the location of fragmentation of said target ions of interest.