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公开(公告)号：US12087568B2
公开(公告)日：2024-09-10
申请号：US18456678
申请日：2023-08-28
Applicant: Standard BioTools Canada Inc.
Inventor： Alexander Loboda , Raymond Jong , Michael Sullivan , Serguei Vorobiev , Robert Rotenberg , Emil D. Stratulativ , Maxim Voronov , Mark Armstrong
CPC classification number: H01J49/105 , H01J49/0027 , H01J49/0463 , H05H1/2406 , H05H1/30
Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.
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Patent Agency Ranking
公开(公告)号：US20250093252A1
公开(公告)日：2025-03-20
申请号：US18726639
申请日：2023-01-09
Applicant: Standard BioTools Canada Inc.
Inventor： Alexander Loboda , Adam Carew
IPC: G01N15/1404 , G01N15/10 , H01J49/00 , H01J49/04 , H01J49/10
Abstract: A coupling tube made of a stretchable elastomeric material. The “stretchy” coupling tubing allows for improved reliability/repeatability of coupling performance. For example, the stretch provided can take up tolerances between positions of imager and reader instruments. In one example, the stretch can take up tolerances between positions of the junction between the rigid portion of tubing inside the IMC unit and the injector to an ionization source. The coupling tube may also be provided with a reduced inner diameter (ID) as compared to standard coupling components. A taper in the inner diameter (ID) can occur before the flow enters the stretchable coupling tube. Barbed ends may also be provided for securing the coupling tube into place.
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公开(公告)号：US20230215714A1
公开(公告)日：2023-07-06
申请号：US17785887
申请日：2020-12-21
Applicant: Standard BioTools Canada Inc.
Inventor： Adam Carew , Daaf Sandkuijl , Alexander Loboda , Matthew Weel , Dmitry Bandura
CPC classification number: H01J49/0004 , H01J49/40 , H01J49/0463
Abstract: Described herein are systems and methods for imaging mass spectrometry, including imaging mass cytometry. Aspects of the subject application include apparatus and methods for imaging mass spectrometry (IMS) that improve speed of sample acquisition, signal sensitivity, and/or signal stability. Systems and methods described herein may minimize the transfer time and/or may minimize the spread of plumes of sample material ablated from a sample to be transferred to the components of the imaging mass spectrometer or mass cytometer that ionize and analyze the sample material.
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公开(公告)号：US20240369566A1
公开(公告)日：2024-11-07
申请号：US18752407
申请日：2024-06-24
Applicant: Standard BioTools Canada Inc.
Inventor： Alexander Loboda , Raymond Jong , Michael Sullivan , Serguei Vorobiev , Robert Rotenberg , Emil D. Stratulativ , Maxim Voronov , Mark Armstrong
Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.
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公开(公告)号：US20240361304A1
公开(公告)日：2024-10-31
申请号：US18657098
申请日：2024-05-07
Applicant: Standard BioTools Canada Inc.
Inventor： Vladimir Baranov , Alexander Loboda , Michael Sullivan
CPC classification number: G01N33/5306 , G01N33/58 , H01J49/105 , G01N2458/15 , G01N2560/00
Abstract: Analyzing samples injected into an inductively coupled plasma source can be improved by one or more of a stabilizing solution mixable with a sample prior to injection and a heated injector. The stabilizing solution can minimize the difference in osmotic pressure between the solution and the cells with a relatively low amount of dissolved solids (e.g., at or below about 0.2%). The stabilizing solution can contain a salt (e.g., ammonium nitrate) present in concentrations of at least 5 mM. The injector can be heated before and/or during injection. In some cases, heat from adjacent parts can be channeled into the injector to improve heating of the injector. An injector heated to sufficient temperatures can minimize solute buildup and can extend the usable time between cleanings. These improvements can be especially useful in elemental analysis, such as inductively coupled plasma mass spectrometry or inductively coupled plasma optical emission spectrometry.
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公开(公告)号：US20230411136A1
公开(公告)日：2023-12-21
申请号：US18456678
申请日：2023-08-28
Applicant: Standard BioTools Canada Inc.
Inventor： Alexander Loboda , Raymond Jong , Michael Sullivan , Serguei Vorobiev , Robert Rotenberg , Emil D. Stratulativ , Maxim Voronov , Mark Armstrong
CPC classification number: H01J49/105 , H01J49/0027 , H01J49/0463 , H05H1/2406 , H05H1/30
Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.
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