公开(公告)号：US20210210332A1

公开(公告)日：2021-07-08

申请号：US17058549

申请日：2019-01-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. JARROLD ,  Benjamin E. DRAPER

IPC: H01J49/42 ,  H01J49/02 ,  H01J49/00

Abstract: A charge detection mass spectrometer may include an electrostatic linear ion trap (ELIT) or an orbitrap, an ion source to supply ions thereto, at least one amplifier operatively coupled to the ELIT or orbitrap, a processor coupled to ELIT or orbitrap and to the amplifier(s), and processor programmed to control the ELIT or orbitrap as part of a trapping event to attempt to trap therein a single ion supplied by the ion source, to record ion measurement information based on output signals produced by the amplifier(s) over a duration of the trapping event, to determine, based on the measurement information, whether the control of the ELIT or orbitrap resulted in trapping of a single ion, no ion or multiple ions, and to compute an ion mass or mass-to-charge ratio from the measurement information only if a single ion was trapped during the trapping event.

公开(公告)号：US20220230866A1

公开(公告)日：2022-07-21

申请号：US17711126

申请日：2022-04-01

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. JARROLD ,  Benjamin E. DRAPER

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/02

Abstract: A charge detection mass spectrometer may include an electrostatic linear ion trap (ELIT) or orbitrap, a source of ions to supply ions to the ELIT or orbitrap, a processor operatively coupled to the ELIT or orbitrap, a display monitor coupled to the processor, and a memory having instructions stored therein executable by the processor to produce a control graphic user interface (GUI) on the display monitor, the control GUI including at least one selectable GUI element for at least one corresponding operating parameter of the ELIT or orbitrap, receive a first user command, via user interaction with the control GUI, corresponding to selection of the at least one selectable GUI element, and control the ELIT or orbitrap to control the at least one corresponding operating parameter of the ELIT or orbitrap in response to receipt of, and based on, the first user command.

公开(公告)号：US20230048598A1

公开(公告)日：2023-02-16

申请号：US17791981

申请日：2021-02-03

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. JARROLD ,  David E. CLEMMER ,  Benjamin E. DRAPER ,  Lauren F. BARNES

IPC: C12N7/00 ,  G01N33/68

Abstract: A method for reducing heterogeneity of a virus preparation may include generating virus ions from the virus preparation, repeatedly increasing at least one of a temperature and an incubation period at the increased temperature of at least one of the virus preparation and the generated virus ions, measuring mass-to-charge ratios and charge magnitudes of at least some of the generated virus ions at each increase of the at least one of the temperature and the incubation period, determining a mass spectrum at each increase of the at least one of the temperature and the incubation period based on values of the respective mass-to-charge ratios and charge magnitudes, and determining, based on the mass spectrums, optimum ones of the temperature and the incubation period which together minimize, or at least reduce, a heterogeneity of the virus preparation without aggregation of virus capsids in the virus preparation.

公开(公告)号：US20210193447A1

公开(公告)日：2021-06-24

申请号：US17058544

申请日：2019-06-04

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. JARROLD ,  Staci N. ANTHONY ,  Benjamin E. DRAPER

IPC: H01J49/06 ,  H01J49/02 ,  H01J49/24 ,  H01J49/42

Abstract: An interface transports ions from a first pressure environment to a lower pressure analysis instrument and may include a first region pumped to a second pressure less than the first pressure, a first ion funnel disposed in the first region, a first ion carpet in the first region opposite an ion outlet end of the first ion funnel, a second region pumped to a third pressure less than the second pressure and greater than the instrument pressure, a second ion funnel disposed in the second region and a second ion carpet in the second region opposite an ion outlet end of the second ion funnel. Ions from the environment pass sequentially through the first and second ion funnels and into the analysis instrument. Each of the first and second ion funnels define a tapered axial passageway therethrough each defining a respective virtual jet disrupter therein.