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    NEW SERINE PROTEASE FROM PROSTATA
    1.
    发明专利
    NEW SERINE PROTEASE FROM PROSTATA 失效

    公开(公告)号：JP2000023678A

    公开(公告)日：2000-01-25

    申请号：JP3476299

    申请日：1999-02-12

    Applicant: BASF AG

    Inventor： KROEGER BURKHARD DR

    IPC: C12N15/09 ,  A61K38/55 ,  A61K48/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/55 ,  C12N15/57 ,  C12R1/91 ,  C07K16/40 ,  C12N1/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N9/50 ,  C12Q1/68 ,  G01N33/53

    Abstract: PROBLEM TO BE SOLVED: To obtain a new serine protease protein which contains a specific amino acid sequence, consists of a serine protease protein arising from prostata and is useful for diagnosis, treatment or the like for diseases of prostata and genital system, e.g. prostatic hypertrophy, prostatic cancer, breast cancer, spermatheca disease and the like. SOLUTION: This protein is a new serine protease protein arising from prostata, which is composed of the isolated protein containing the amino acid sequence represented by the formula or the protein obtained by substituting, inserting or deleting at least one amino acid residues from the isolated protein and contains the sequence having at least one of main biological specific characteristics of the protein represented by the formula, and is useful in the diagnosis or the treatment for disease of prostata or genital system and in the diagnosis or the treatment for spermatheca disease, breast cancer, prostatic cancer and prostatic hypertrophy or its metastasis. This protein is prepared by introducing an expression system obtained by integrating a nucleotide sequence that codes for serine protease identified by a cDNA library from human prostata into host cells to transform and then cultivating this.

    NEW G PROTEIN-COUPLED RECEPTOR FROM HUMAN BRAIN
    2.
    发明专利
    NEW G PROTEIN-COUPLED RECEPTOR FROM HUMAN BRAIN 失效

    公开(公告)号：JPH11318452A

    公开(公告)日：1999-11-24

    申请号：JP3149799

    申请日：1999-02-09

    Applicant: BASF AG

    Inventor： KROEGER BURKHARD DR ,  OTTERBACH BERND DR

    IPC: C12N15/09 ,  A61K48/00 ,  C07K14/705 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/00 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

    Abstract: PROBLEM TO BE SOLVED: To obtain an isolated protein having an activity as a G protein-coupled receptor and useful for the treatment of diseases, etc., in the central nervous system or the peripheral nervous system such as Alzheimer disease by providing a specific amino acid sequence. SOLUTION: This receptor is a human protein having an amino acid sequence represented by the formula or a sequence in which one or more amino acid residues are substituted, inserted or deleted therefrom and retaining one or more main biological characteristics of the protein represented by the formula at that time. A cell having the protein on the cell surface is preferably combined with many substances to be investigated and the biological activity of the receptor is then compared in the presence (absence) of the substances to be tested to identify an antagonist and an agonist of the protein. A biological sample together with an antibody specifically to the protein is kept at a constant temperature to detect an antibody/antigen complex. The amount of the antibody/ antigen complex is preferably compared with the standard to qualitatively and quantitatively detect the protein in the biological sample.

    ANALYTICAL MEASURING METHOD AND ITS USE
    3.
    发明专利
    ANALYTICAL MEASURING METHOD AND ITS USE 失效

    公开(公告)号：JPH11160314A

    公开(公告)日：1999-06-18

    申请号：JP27147598

    申请日：1998-09-25

    Applicant: BASF AG

    Inventor： EIPEL HEINZ ,  KELLER HARALD DR ,  KROEGER BURKHARD DR ,  PHILIPP SABINE DR

    IPC: G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/551

    Abstract: PROBLEM TO BE SOLVED: To provide an analytical measuring method and its use. SOLUTION: In an analytical measuring method, a reagent singly or a mixture of a reagent is individually applied to hydrophilic measurement zones 1 on a base material 5. The base material 5 is treated with at least one type of reagent common to all the measurement zones to add the reagent to the hydrophilic measurement zones 1. The measurement zones are cleaned after the application of the reagent or after the mutual reaction time of the reagents has elapsed depending on the case. and the measurement zones are measured together or singly. This method is used for a diagnosing method, the examination and of active substances, combinatorial chemistry, crop protection, toxicology, or environmental protection.

    Test for cpd. that inhibits expression of plasminogen activator inhibitor one
    8.
    发明专利
    Test for cpd. that inhibits expression of plasminogen activator inhibitor one 未知

    公开(公告)号：DE4341078A1

    公开(公告)日：1995-06-08

    申请号：DE4341078

    申请日：1993-12-02

    Applicant: BASF AG

    Inventor： KROEGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR

    IPC: C12Q1/68 ,  C12Q1/6897 ,  C12Q1/66

    Abstract: Identification of substances (A) that inhibit expression of plasminogen activator inhibitor-1 (I) comprises: (i) transfecting a host cell with a recombinant vector that contains a regulatory region of the (I) gene functionally attached to a reporter gene (RG); (ii) either (iia) establishing a cell line that transiently contains the vector or (iib) growing a cell line that has stably integrated the vector; (3) treating the cell lines of either sort with test cpds.; and (4) measuring expression of RG.

    Identifying cpds. that act upon serotonin 5-HT-1D receptors
    9.
    发明专利
    Identifying cpds. that act upon serotonin 5-HT-1D receptors 未知

    公开(公告)号：DE4427394A1

    公开(公告)日：1996-02-08

    申请号：DE4427394

    申请日：1994-08-03

    Applicant: BASF AG

    Inventor： BIALOJAN SIEGFRIED DR ,  KROEGER BURKHARD DR

    IPC: C12Q1/68 ,  C12Q1/6897 ,  C12Q1/66 ,  G01N33/53

    Abstract: Method for identifying substances (I) that act on the serotonin 5HT-1D receptor (A) comprises: (a) transfecting a host cell that recombinantly and stably expresses (A) with a recombinant vector contg.: (i) a promoter that is activated by elevation of the level of second messengers; and (ii) a functionally coupled reporter gene (RG); (b) establishing cells that transiently contain, or have stably integrated, the vector; (c) exposing these cells to test cpd.; and (d) measuring expression of RG.

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