4.
    发明专利
    未知

    公开(公告)号:AT198189T

    公开(公告)日:2001-01-15

    申请号:AT96915021

    申请日:1996-05-07

    Applicant: BASF AG

    Abstract: PCT No. PCT/EP96/01884 Sec. 371 Date Oct. 28, 1997 Sec. 102(e) Date Oct. 28, 1997 PCT Filed May 7, 1996 PCT Pub. No. WO96/35660 PCT Pub. Date Nov. 14, 1996A process for preparing enantiomerically pure cis-1-amino-2-hydroxyindane, which comprises a) converting racemic trans-1-aminoindan-2-ol with acids or acid derivatives of the general formula RCOX by conventional methods into amides of type A A b) adding seed crystals of one enantiomer to a super-saturated solution or melt of the racemic amide A, c) isolating the crystals which have separated out, and again supersaturating the remaining mother liquor or melt after dissolving racemic amide A, and adding seed crystals of the other enantiomer, leading to selective crystallization of the latter, d) converting the resulting enantiomerically pure trans amide by conventional methods into the enantiomerically pure cis-1-amino-2-hydroxyindane.

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