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    IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL
    1.
    发明申请
    IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL 审中-公开
    使用动态控制改善热循环仪器的热均匀性

    公开(公告)号：WO2011127386A2

    公开(公告)日：2011-10-13

    申请号：PCT/US2011031750

    申请日：2011-04-08

    Applicant: LIFE TECHNOLOGIES CORP ,  CONNER THOMAS A ,  LIM CHEE KIONG ,  PALLAS MICHAEL C ,  CHING CHEE WEE

    Inventor： CONNER THOMAS A ,  LIM CHEE KIONG ,  PALLAS MICHAEL C ,  CHING CHEE WEE

    IPC: C12Q1/68 ,  C12M1/38 ,  G01N33/50

    CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1894

    Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

    Abstract translation: 提供了一种用于提高热不均匀性的聚合酶链反应（PCR）的方法。 该方法包括通过第一传感器测量样品块的第一样品块扇区的第一温度，并由第二传感器测量与第一样品块相邻的样品块的第二样品块扇区的第二温度 样品块部门。 该方法还包括通过热电控制器计算第一温度和第二温度之间的温度差，并且由热电控制器通过使用一个或多个温度控制器来调节基于温差的第一样品块扇区的第一温度 更多热电冷却器。 一个或多个热电冷却器被配置为通过调节从热电控制器输出的功率来加热或冷却第一样品块扇区。

    SYSTEMS AND METHODS FOR LOADING LIQUID SAMPLES
    5.
    发明专利
    SYSTEMS AND METHODS FOR LOADING LIQUID SAMPLES 未知

    公开(公告)号：IN8164DEN2014A

    公开(公告)日：2015-05-01

    申请号：IN8164DEN2014

    申请日：2014-09-30

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： PALLAS MICHAEL C ,  NURSE JAMES ,  LIM GARY ,  STRAUB THEODORE ,  FOSTER EVAN

    IPC: B01L3/02

    Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further in various embodiments the liquid sample has an advancing contact angle of 85 +/-15 degrees with the first and second blade. Furthermore loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.

    COATED SUBSTRATE FOR BIOLOGICAL REACTION SYSTEMS
    6.
    发明专利
    COATED SUBSTRATE FOR BIOLOGICAL REACTION SYSTEMS 未知

    公开(公告)号：IN8136DEN2014A

    公开(公告)日：2015-05-01

    申请号：IN8136DEN2014

    申请日：2014-09-29

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： GHENCIU ELIODOR ,  FOSTER EVAN ,  STRAUB THEODORE ,  PALLAS MICHAEL C

    IPC: B01L3/00 ,  B01L3/02 ,  C40B60/14

    Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.

    COATED SUBSTRATE FOR BIOLOGICAL REACTION SYSTEMS
    8.
    发明专利
    COATED SUBSTRATE FOR BIOLOGICAL REACTION SYSTEMS 未知

    公开(公告)号：SG11201405788UA

    公开(公告)日：2014-11-27

    申请号：SG11201405788U

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： GHENCIU ELIODOR ,  FOSTER EVAN ,  STRAUB THEODORE ,  PALLAS MICHAEL C

    IPC: B01L3/00 ,  B01L3/02 ,  C40B60/14

    Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.

    Coated substrate for biological reaction systems
    9.
    发明专利
    Coated substrate for biological reaction systems 未知

    公开(公告)号：AU2013231889A1

    公开(公告)日：2014-10-30

    申请号：AU2013231889

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： GHENCIU ELIODOR ,  FOSTER EVAN ,  STRAUB THEODORE ,  PALLAS MICHAEL C

    IPC: B01L3/00 ,  B01L3/02 ,  C40B60/14

    Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.

    IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL
    10.
    发明公开
    IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL 审中-公开
    改进WÄRMEUNIFORMITÄTTO仪器热循环使用动态控制

    公开(公告)号：EP2556173A4

    公开(公告)日：2013-12-04

    申请号：EP11766806

    申请日：2011-04-08

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： CONNER THOMAS A ,  LIM CHEE KIONG ,  PALLAS MICHAEL C ,  CHING CHEE WEE

    IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00 ,  C12M1/38 ,  G01N33/50

    CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1894

    Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

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