IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL
    3.
    发明申请
    IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL 审中-公开
    使用动态控制改善热循环仪器的热均匀性

    公开(公告)号:WO2011127386A2

    公开(公告)日:2011-10-13

    申请号:PCT/US2011031750

    申请日:2011-04-08

    CPC classification number: B01L7/52 B01L2200/147 B01L2300/1822 B01L2300/1894

    Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

    Abstract translation: 提供了一种用于提高热不均匀性的聚合酶链反应(PCR)的方法。 该方法包括通过第一传感器测量样品块的第一样品块扇区的第一温度,并由第二传感器测量与第一样品块相邻的样品块的第二样品块扇区的第二温度 样品块部门。 该方法还包括通过热电控制器计算第一温度和第二温度之间的温度差,并且由热电控制器通过使用一个或多个温度控制器来调节基于温差的第一样品块扇区的第一温度 更多热电冷却器。 一个或多个热电冷却器被配置为通过调节从热电控制器输出的功率来加热或冷却第一样品块扇区。

    APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING SCALABLE THERMAL CYCLERS AND ISOLATING THERMOELECTRIC DEVICES

    公开(公告)号:SG11201606590UA

    公开(公告)日:2016-09-29

    申请号:SG11201606590U

    申请日:2015-02-04

    Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.

    APARATOS, SISTEMAS Y METODOS PARA PROPORCIONAR UNIFORMIDAD TERMICA DE TERMOCICLADOR.

    公开(公告)号:MX2016003395A

    公开(公告)日:2016-06-24

    申请号:MX2016003395

    申请日:2014-09-15

    Abstract: Se describe un montaje de bloque térmico que incluye un bloque de muestras y dos o más dispositivos termoeléctricos; el bloque de muestras tiene una superficie superior configurada para recibir múltiples recipientes de reacción y una superficie inferior opuesta; los dispositivos termoeléctricos están acoplados operativamente con el mismo bloque, en donde cada dispositivo termoeléctrico incluye una cubierta para un sensor térmico y una interfaz de control térmico con un controlador; cada dispositivo termoeléctrico está configurado adicionalmente para funcionar independientemente de los otros para proporcionar un perfil de temperatura sustancialmente uniforme en todo el bloque de muestras.

    IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL

    公开(公告)号:SG184539A1

    公开(公告)日:2012-11-29

    申请号:SG2012075255

    申请日:2011-04-08

    Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

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