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    REAL-TIME REDOX SEQUENCING
    1.
    发明申请
    REAL-TIME REDOX SEQUENCING 审中-公开
    实时REDOX测序

    公开(公告)号：WO2013056241A3

    公开(公告)日：2013-06-20

    申请号：PCT/US2012060275

    申请日：2012-10-15

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  SUN LEI

    IPC: C12Q1/68 ,  C12Q1/48 ,  G01N27/26

    CPC classification number: C12Q1/6869 ,  B82Y15/00 ,  C12Q1/001 ,  C12Q2521/543 ,  C12Q2563/113 ,  C12Q2565/607 ,  C40B60/10 ,  G01N27/00 ,  G01N27/3277 ,  G01N27/3278 ,  C12Q2563/155

    Abstract: Real time redox sequencing methods, devices, and systems are described. Arrays of redox devices comprising one or two electrodes are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the electrode(s). A sequencing reaction mixture comprising nucleotide analogs comprising redox labels is introduced to the array of redox devices under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by electrochemically identifying the redox labels of the nucleotide analogs that are incorporated into the growing strand.

    Abstract translation: 描述了实时氧化还原测序方法，设备和系统。 使用包含一个或两个电极的氧化还原装置的阵列来提供关于靠近电极的聚合酶 - 模板复合物中的模板核酸的序列信息。 将包含氧化还原标记的核苷酸类似物的测序反应混合物在聚合酶介导的核酸合成的条件下引入到氧化还原装置阵列中。 通过电化学鉴定掺入生长链中的核苷酸类似物的氧化还原标记来确定核苷酸类似物的掺入时间序列。

    Uniform surfaces for hybrid material substrates and methods for making and using same
    10.
    发明专利
    Uniform surfaces for hybrid material substrates and methods for making and using same 未知

    公开(公告)号：AU2006320739A1

    公开(公告)日：2007-06-07

    申请号：AU2006320739

    申请日：2006-11-27

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： KORLACH JONAS

    IPC: C23C16/00

    Abstract: Devices, systems and methods of using same where hybrid substrate materials are provided with a substantially uniform surface to provide uniformity of properties, including interaction with their environments. Uniform surfaces are applied as coatings over, e.g., hybrid metal/silica, metal/polymer, metal/metal surfaces to mask different chemical properties of differing regions of the surface and to afford a protective surface for the hybrid structure.

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