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公开(公告)号：ES2385015T3
公开(公告)日：2012-07-17
申请号：ES07754529
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
Abstract: Un método de proporcionar un sustrato que tiene una enzima inmovilizada selectivamente sobre él, comprendiendoel método:proporcionar un sustrato que tiene un primer componente de la superficie que comprende SiO2 y un segundocomponente de la superficie que comprende un metal u óxido metálico;poner en contacto el sustrato con una primera composición que se asocia selectivamente con el primer componentede la superficie, comprendiendo dicha primera composición un silano;acoplar la enzima a la primera composición; yponer en contacto el sustrato con una segunda composición que se asocia selectivamente con el segundocomponente de la superficie, comprendiendo dicha segunda composición un compuesto que comprende uno o másgrupos ácido fosfónico o fosfato.
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公开(公告)号：CA2645758A1
公开(公告)日：2007-11-01
申请号：CA2645758
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： OTTO GEOFF , WEGENER JEFFERY , KORLACH JONAS , RANK DAVID R , XU YUE , PELUSO PAUL , ROITMAN DANIEL , TURNER STEPHEN , LYLE JOHN
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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公开(公告)号：AU2008331824B2
公开(公告)日：2014-07-24
申请号：AU2008331824
申请日：2008-12-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： FLUSBERG BENJAMIN , EID JOHN , OTTO GEOFF , KORLACH JONAS , ROITMAN DANIEL , HARDENBOL PAUL
IPC: G01N33/53 , G01N33/535 , G01N33/573
Abstract: Systems and methods of enhancing fluorescent labeling strategies as well as systems and methods of using non-fluorescent and/or non-optic labeling strategies, e.g., as with single molecule sequencing using ZMWs, are described.
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公开(公告)号：AU2012216605B2
公开(公告)日：2014-06-12
申请号：AU2012216605
申请日：2012-09-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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公开(公告)号：WO2009073201A2
公开(公告)日：2009-06-11
申请号：PCT/US2008013363
申请日：2008-12-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , ROITMAN DANIEL , EID JOHN , OTTO GEOFF , HARDENBOL PAUL , FLUSBERG BENJAMIN
Inventor： KORLACH JONAS , ROITMAN DANIEL , EID JOHN , OTTO GEOFF , HARDENBOL PAUL , FLUSBERG BENJAMIN
IPC: G01N33/573 , G01N33/53
CPC classification number: G01N33/54373 , C12Q1/6874 , G01N33/542 , G01N33/54313 , G01N33/573 , G01N33/58 , G01N33/585 , C12Q2565/607 , C12Q2565/531 , C12Q2563/143 , C12Q2563/137
Abstract: Systems and methods of enhancing fluorescent labeling strategies as well as systems and methods of using non-fluorescent and/or non-optic labeling strategies, e.g., as with single molecule sequencing using ZMWs, are described.
Abstract translation: 描述了增强荧光标记策略的系统和方法以及使用非荧光和/或非光学标记策略的系统和方法，例如与使用ZMW的单分子测序一样。
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Patent Agency Ranking6.发明申请ARTICLES HAVING LOCALIZED MOLECULES DISPOSED THEREON AND METHODS OF PRODUCING SAME 审中-公开具有本地化分子的制品及其生产方法
公开(公告)号：WO2007123763A3
公开(公告)日：2008-11-06
申请号：PCT/US2007008019
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF
CPC classification number: C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
Abstract translation: 通过使用底物的元素来辅助活性化学基团在基底的所需区域中的定位来制备具有选定的活性化学区域的基底的方法。 所述方法可以包括用于沉积，去除，激活和/或去活衬底的选定区域中的化学基团的光学，化学和/或机械方法，以提供衬底的选择性活性区域。
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公开(公告)号：AU2012216605A1
公开(公告)日：2012-09-20
申请号：AU2012216605
申请日：2012-09-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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8.发明专利
公开(公告)号：DK2002019T3
公开(公告)日：2012-06-18
申请号：DK07754529
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , WEGENER JEFFERY , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , KORLACH JONAS , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
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公开(公告)号：AU2008331824A1
公开(公告)日：2009-06-11
申请号：AU2008331824
申请日：2008-12-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： OTTO GEOFF , EID JOHN , KORLACH JONAS , HARDENBOL PAUL , FLUSBERG BENJAMIN , ROITMAN DANIEL
IPC: G01N33/53 , G01N33/535 , G01N33/573
Abstract: Systems and methods of enhancing fluorescent labeling strategies as well as systems and methods of using non-fluorescent and/or non-optic labeling strategies, e.g., as with single molecule sequencing using ZMWs, are described.
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公开(公告)号：CA2645758C
公开(公告)日：2016-08-09
申请号：CA2645758
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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