公开(公告)号：FI793552A

公开(公告)日：1980-05-19

申请号：FI793552

申请日：1979-11-13

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN DIETER

IPC: A61K31/55 ,  C07D223/16 ,  C07D405/12 ,  C07D

公开(公告)号：AU5214479A

公开(公告)日：1980-05-01

申请号：AU5214479

申请日：1979-10-24

Applicant: BASF AG

Inventor： TREIBER HANS JOERG ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

公开(公告)号：NO791427A

公开(公告)日：1979-10-30

申请号：NO791427

申请日：1979-04-27

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D

CPC classification number: C07D285/12 ,  Y10S514/821

公开(公告)号：FI780842A

公开(公告)日：1978-09-18

申请号：FI780842

申请日：1978-03-17

Applicant: BASF AG

Inventor： PHILIPSBORN GERDA VON ,  BOELL WALTER ,  LENKE DIETER

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：DK164699B

公开(公告)日：1992-08-03

申请号：DK416082

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT ,  HEGE HANS-GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  PHILIPSBORN GERDA VON ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C217/36 ,  C07C323/25 ,  C07D207/08 ,  C07D211/14 ,  C07D295/088

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：FI86174C

公开(公告)日：1992-07-27

申请号：FI844729

申请日：1984-11-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  VON PHILIPSBORN GERDA ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：DK159428C

公开(公告)日：1991-03-18

申请号：DK147382

申请日：1982-03-31

Applicant: BASF AG

Inventor： STEINER GERD ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/00 ,  A61K31/55 ,  A61P1/04 ,  C07D223/20 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07F9/59

公开(公告)号：AU587661B2

公开(公告)日：1989-08-24

申请号：AU6610086

申请日：1986-12-04

Applicant: BASF AG

Inventor： SEITZ WERNER ,  BALDINGER VERENA ,  GRIES JOSEF ,  LENKE DIETER ,  RASCHACK MANFRED ,  RUEBSAMEN KLAUS

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00 ,  C07C95/08 ,  C07D319/08

公开(公告)号：CA1251797A

公开(公告)日：1989-03-28

申请号：CA449702

申请日：1984-03-15

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  GRIES JOSEF ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: C07D211/52 ,  A61K31/13 ,  A61K31/445 ,  A61K31/451 ,  A61P9/06 ,  C07C67/00 ,  C07C213/00 ,  C07C217/32 ,  C07C313/00 ,  C07C323/25 ,  C07D211/44 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07C93/14 ,  C07D295/10

Abstract: Compounds of the general formula (I): (I) can be made by reduction of their corresponding 2-hydroxy- -phenylpropiophenones. In formula (I), R1 and R2 are optionally substituted hydrocarbon radicals possibly forming a ring with the nitrogen atom to which they are attached. R3 is an optionally substituted hydrocarbon or halogen. R4 may be the same as R3 or a substituted amino group and n is 1 or 2. Any of R1 to R4 may individually be hydrogen. An example is 1-¢2-(2'-hydroxy-3'-piperidinopropoxy)-phenyl!-3-phenylpropanol. The compounds and their physiologically tolerated addition salts with acids prosess antiarrhythmic, .beta.-sympatholytic and Ca-antagonistic properties and can therefore be used, in particular, for the pharmacotherapeutic treatment of cardiac arrhythmias, the prevention of sudden cardiac death and the treatment of coronary diseases of the heart.

公开(公告)号：FI76083B

公开(公告)日：1988-05-31

申请号：FI821141

申请日：1982-04-01

Applicant: BASF AG

Inventor： STEINER GERD ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/00 ,  A61K31/55 ,  A61P1/04 ,  C07D223/20 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07F9/59