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    METHOD FOR PREPARING 1,3,4-SUBSTITUTED PYRAZOL COMPOUNDS
    97.
    发明专利
    METHOD FOR PREPARING 1,3,4-SUBSTITUTED PYRAZOL COMPOUNDS 未知

    公开(公告)号：ZA201008637B

    公开(公告)日：2014-08-27

    申请号：ZA201008637

    申请日：2010-12-01

    Applicant: BASF SE

    Inventor： WOLF BERND ,  MAYWALD VOLKER ,  KEIL MICHAEL ,  KORADIN CHRISTOPHER ,  RACK MICHAEL ,  ZIERKE THOMAS ,  SUKOPP MARTIN

    IPC: C07D20060101

    Abstract: The present invention relates to a process for preparing 1,3-substituted pyrazole compounds of the formula I in which X is especially a CX1X2X3 group in which X1, X2 and X3 are each independently especially hydrogen, fluorine or chlorine, R1 is C1-C4-alkyl or cyclopropyl, and R2 is hydrogen, CN or a CO2R2a group in which R2a is especially C1-C6-alkyl, comprising the following steps: i) reacting a compound of the formula II with a hydrazone of the formula III where the variables X and R2 in formula II are each as defined for formula I, Y is oxygen, an NRy1 group or an [NRy2Ry3]+Z- group, R3 is OR3a or an NR3bR3c group, and where the variable R1 in formula III is as defined for formula I, R4 and R5 are each independently hydrogen, C1-C6-alkyl, optionally substituted phenyl, where at least one of the R4 and R5 radicals is different from hydrogen, and where R4 and R5 together with the carbon atom to which they are bonded may also be a 5- to 10-membered saturated carbocycle; ii) treating the reaction product obtained with an acid in the presence of water.

    Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates
    100.
    发明专利
    Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates 未知

    公开(公告)号：AU2009218414B2

    公开(公告)日：2013-05-16

    申请号：AU2009218414

    申请日：2009-02-27

    Applicant: BASF SE

    Inventor： SMIDT SEBASTIAN PEER ,  ZIERKE THOMAS ,  WOLF BERND ,  RACK MICHAEL ,  KORADIN CHRISTOPHER ,  MAYWALD VOLKER ,  KEIL MICHAEL

    IPC: C07C67/343 ,  C07C69/72

    Abstract: A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting alkyl acetate (II), RO M alkoxide (III), where M is a sodium or potassium ion, and alkyl difluoroacetate (IV), without additional solvent to form an enolate (V), b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates (VII).

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