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    PRODUCTION OF ALKANESULFONATE
    92.
    发明专利
    PRODUCTION OF ALKANESULFONATE 失效

    公开(公告)号：JPS6089466A

    公开(公告)日：1985-05-20

    申请号：JP19875383

    申请日：1983-10-24

    Applicant: KAO CORP

    Inventor： KAWAMATA AKIRA ,  TAKAISHI NAOTAKE

    IPC: C07C309/04 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/32

    Abstract: PURPOSE:To obtain the titled compound useful as a surfactant capable of exhibiting particularly detergency in hard water in high selectivity and yield, by reacting an alpha-sulfofatty acid derivative with a specific amount of water in a closed system under heating. CONSTITUTION:An alpha-sulfofatty acid derivative of formula I (R1 is 2-20C alkyl; A is H, 1-6C alkyl, alkali metal, alkaline earth metal or ammonium ion; M is alkali metal, alkaline earth metal or ammonium ion) is reacted with water in an amount of 20wt% or more, preferably equal amount -4 times, based on the amount of the alpha-sulfofatty acid in a closed system, e.g. an autoclave, at >=250 deg.C, preferably 300-350 deg.C for 1-3hr under heating to afford the aimed substance of formula II.

    NEW SILOXANE DERIVATIVE
    93.
    发明专利
    NEW SILOXANE DERIVATIVE 失效

    公开(公告)号：JPH09194594A

    公开(公告)日：1997-07-29

    申请号：JP26169696

    申请日：1996-10-02

    Applicant: KAO CORP

    Inventor： TAKEUCHI MASARU ,  YOSHINO KOJI ,  SUZUKI YUJI ,  KAWAMATA AKIRA

    IPC: A61K8/55 ,  A61K8/58 ,  A61K8/72 ,  A61K8/89 ,  A61Q1/00 ,  A61Q1/12 ,  B01F17/54 ,  C07F7/08 ,  C08G77/14 ,  C08G77/22 ,  C08G77/38 ,  C08L83/06

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject new derivative having surface active action, useful as an emulsifying agent, providing a cosmetic excellent in emulsion stability, by reacting a specific organohydrogenpolysiloxane with an alkenyl glycerol ether. SOLUTION: An organohydrogenpolysiloxane of formula I (at least one of R to R is H and the rest are each a 1-30C hydrocarbon; (l), (m) and (n) are each 0-2,000) is hydrosilylated with an alkenyl glycerol ether of formula II (R and R are each H or a 1-5C hydrocarbon; Q is a 3-20C hydrocarbon containing at least one double bond) in the presence of a catalyst such as chloroplatinic acid in a solvent such as isopropyl alcohol. The protecting group of the hydroxyl group is removed to give the objective new siloxane of formula III (at least one of R to R is a group of formula IV, at least one of the rest is a 6-30C hydrocarbon group and the rest are each methyl).

    SKIN EXTERNAL PREPARATION
    97.
    发明专利
    SKIN EXTERNAL PREPARATION 失效

    公开(公告)号：JPH06271447A

    公开(公告)日：1994-09-27

    申请号：JP6060193

    申请日：1993-03-19

    Applicant: KAO CORP

    Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KUSUOKU HIROSHI ,  KAWAMATA AKIRA ,  FUJIMURA TSUTOMU ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  TAKEMA YOSHINORI ,  IMOKAWA GENJI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61K31/13 ,  A61K31/16 ,  A61K31/215 ,  A61P17/00 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To obtain a skin external preparation excellent in action capable of suppressing occurrence of wrinkle and removing wrinkle and suppressing parakeratosis of skin, hyperplasia of epidermis and abnormality of lipometabolism and excellent in the recovery of normal function and retention of homeostasis. CONSTITUTION:This skin external preparation contains a compound of formula I [R and R are H or 1-40C hydrocarbon group (which may have OH, COOH, alkoxy, alkylthio, acylamino or acyloxy; R is H or 1-40C hydrocarbon group (which may have alkoxy, alkylthio, acylamino or acyloxy) or 1-40C hydrocarbon group having OH or COOH; total carbon number of R to R is >=5; R and R are H or 1-10C hydrocarbon groups or N atom, R and R together form a cyclic hydrocarbon group which may have an ether oxygen], its acid addition salt or quaternary compound, e.g. 1-benzylamino-tridecane-2,3-diol. This compound has action capable of suppressing DNA synthesis of an epidermic cell, promoting differential induction and suppressing hyperplasia of epidermis. The compound of formula I is obtained by adding an amine of formula 3 to an epoxide of formula 2.

    AMIDE DERIVATIVE AND SKIN EXTERNAL PREPARATION CONTAINING THE SAME
    98.
    发明专利
    AMIDE DERIVATIVE AND SKIN EXTERNAL PREPARATION CONTAINING THE SAME 失效

    公开(公告)号：JPH06157507A

    公开(公告)日：1994-06-03

    申请号：JP31241892

    申请日：1992-11-20

    Applicant: KAO CORP

    Inventor： OHASHI YUKIHIRO ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  TSUKAHARA KAZUE ,  IMOKAWA GENJI

    IPC: A61K8/49 ,  A61K8/00 ,  A61K31/335 ,  A61K31/357 ,  A61P17/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07D317/22 ,  C07D317/32 ,  A61K7/00 ,  A61K7/48

    Abstract: PURPOSE:To obtain a new amide derivative as a skin external preparation capable of fundamentally improving a barrier function of a stratum corneum, e.g. maintaining normal barrier function and recovering and reinforcing lowered barrier function. CONSTITUTION:An amide derivative of formula I [R is 10-40C hydrocarbon; R is 3-39C hydrocarbon; R is a group containing at least one group of the formula X; R and R are H or hydrocarbon or R and R form one hydrocarbon group; X is C(=O) or CH2]. The amide derivative of formula I-A which is a compound of formula I wherein X is CO is obtained by producing a compound of formula IV from an amine derivative of formula II obtained from glycidyl ether, ethanolamine and a hydroxyfatty acid ester of formula III and successively passing through a compound of formula V, a compound of formula VI in order and finally subjecting a compound of formula IX to deprotection. The compound of formula I has good solubility to a base and oxidation stability.

    AMIDE DERIVATIVE AND ITS PRODUCTION INTERMEDIATE, AND SKIN EXTERNAL PREPARATION CONTAINING THE AMIDE DERIVATIVE
    99.
    发明专利
    AMIDE DERIVATIVE AND ITS PRODUCTION INTERMEDIATE, AND SKIN EXTERNAL PREPARATION CONTAINING THE AMIDE DERIVATIVE 失效

    公开(公告)号：JPH06145123A

    公开(公告)日：1994-05-24

    申请号：JP29450492

    申请日：1992-11-02

    Applicant: KAO CORP

    Inventor： FUJIMORI TAKETOSHI ,  OHASHI YUKIHIRO ,  KAWAMATA AKIRA

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K8/42 ,  A61P17/16 ,  A61Q5/00 ,  A61Q19/00 ,  C07C233/18 ,  C07H15/04 ,  A61K7/00 ,  A61K7/48

    Abstract: PURPOSE:To provide a novel amide derivative capable of advantageously produced from a novel production intermediate and useful for skin external preparation enhancing the water retention in horny layer and excellent in a skin roughness-improving effect. CONSTITUTION:The amide derivative of formula I (R is 10-26C linear or branched saturated or unsaturated hydrocarbon; R is H, 1-31C linear or branched saturated or unsaturated hydrocarbon; R , R are 1-20C hydrocarbon which may contain an oxygen atom; a-d are 0-3, provided b and d are not simultaneously 0), e.g. N-(3-hexadesiloxy-2-hydroxypropyl)-N-[3-(2,3- dihydroxypropoxy)-2-hydroxy)-2-hydroxypropyl]hexadecanamide. The compound of formula I is obtained through a novel amine derivative of formula 2 (R is H, benzyl) by the steps of reacting a benzylamine derivative of formula 3 with glycidyl ether; hydrocracking the obtained benzylamine derivative of formula 2A for removing the benzyl group; and subsequently acylating only the secondary amino group of the produced novel amine derivative of formula 2B.

    PRODUCTION OF AMIDE DERIVATIVE
    100.
    发明专利
    PRODUCTION OF AMIDE DERIVATIVE 失效

    公开(公告)号：JPH06135914A

    公开(公告)日：1994-05-17

    申请号：JP29138792

    申请日：1992-10-29

    Applicant: KAO CORP

    Inventor： NAGAI MINORU ,  OHASHI YUKIHIRO ,  TSUKAHARA ITSURO ,  SHIBATA KEIJI ,  KAWAMATA AKIRA

    IPC: B01J23/02 ,  B01J31/12 ,  C07B61/00 ,  C07C231/02 ,  C07C233/18 ,  C07C233/20 ,  C07C235/08

    Abstract: PURPOSE:To produce an amide derivative in high purity and yield by highly selectively amidating an amino-alcohol. CONSTITUTION:An amino-alcohol of formula 2 (R is straight-chain or branched chain hydrocarbon group or H; R is straight-chain or branched chain bivalent hydrocarbon group) is made to react with a carboxylic acid ester of formula 3 (R is straight-chain or branched chain saturated or unsaturated hydrocarbon which may have OH; R is lower hydrocarbon group) or a lactone of formula 4 (R is straight-chain or branched chain saturated or unsaturated bivalent hydrocarbon group which may have OH) in the presence of a basic catalyst, preferably at 60-150 deg.C temperature. The resultant reactional product after completing the reaction is then cooled and kept at a temperature wherein only an amide derivative that is the objective compound deposits in a solid state for >=1hr. Thereby, the amide derivative of formula 1 or 1' is obtained. The amino-alcohol of formula 2 containing remaining compounds of formula 5 or 5' which are by-products can efficiently be made to react by removing the compound of formula 1 or 1' from the reactional equilibrium system.

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