公开(公告)号：AU2015315294B2

公开(公告)日：2020-09-17

申请号：AU2015315294

申请日：2015-09-08

Applicant: ACADEMIA SINICA

Inventor： YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA ,  WONG CHI-HUEY

IPC: C07H15/18 ,  A61K39/39

Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.

公开(公告)号：CA2882294C

公开(公告)日：2019-10-22

申请号：CA2882294

申请日：2013-08-20

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P19/18 ,  C12N9/10 ,  C12N9/12 ,  C12P19/00 ,  C12P19/04 ,  C12P19/30

Abstract: A novel U DP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-serics oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

公开(公告)号：HK1254776A1

公开(公告)日：2019-07-26

申请号：HK18113822

申请日：2018-10-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P20060101

公开(公告)号：HK1254773A1

公开(公告)日：2019-07-26

申请号：HK18113819

申请日：2018-10-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P20060101

公开(公告)号：HK1254772A1

公开(公告)日：2019-07-26

申请号：HK18113818

申请日：2018-10-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P20060101

公开(公告)号：CA2756053C

公开(公告)日：2018-10-30

申请号：CA2756053

申请日：2009-07-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN ,  LIN KUN-HSIEN ,  HUNG JUNG-TUNG

IPC: A61K39/39 ,  A61K31/70 ,  A61P31/04 ,  A61P31/16 ,  A61P35/00

Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (.alpha.- GalCer) analogs, and their use as immunotherapies, adju-vants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cy-tokine response in a subject includes administer-ing an effective amount of a compound to a sub-ject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :; or a pharmaceutically acceptable salt thereof; forming a complex between the com-pound and the antigen-presenting cell, wherein the formation of the complex results in the activa-tion of a receptor on the lymphocyte; and activat-ing the lymphocyte to produce the cytokine re-sponse.

公开(公告)号：HK1246650A1

公开(公告)日：2018-09-14

申请号：HK18106115

申请日：2018-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K20060101 ,  A61P20060101

公开(公告)号：NZ729243A

公开(公告)日：2018-08-31

申请号：NZ72924315

申请日：2015-08-21

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  LEE HSIN-YU

IPC: C07K14/33 ,  C07K14/34

Abstract: This disclosure relates to an immunogenic composition comprising (a) a glycan conjugate comprising at least one glycan with a link and a carrier wherein the or each glycan is conjugated to the carrier through the linker, and (b) optionally an adjuvant. The or each glycan with the linker has a chemical structure of formula (II) wherein R1 is selected from the group consisting of –F, -N3, -NO2, and ORA where RA is an optionally substituted aryl, and R2 is –CH3; or R1 is –OH, and R2 is selected from the group consisting of –CH2F, -CH2N3, -CH2OH, and –C=CH.

公开(公告)号：AU2015305332B2

公开(公告)日：2018-04-12

申请号：AU2015305332

申请日：2015-08-21

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  LEE HSIN-YU

IPC: C07K14/33 ,  C07K14/34

Abstract: This disclosure includes an immunogenic composition containing (a) a glycan conjugate including a carrier and one or more glycans, wherein each of the one or more glycans is conjugated with the carrier through a linker, and optionally (b) an adjuvant. The one or more glycan is each a Globo H derivative.

公开(公告)号：AU2016206315B2

公开(公告)日：2017-12-14

申请号：AU2016206315

申请日：2016-07-21

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P19/04 ,  C12N9/10

Abstract: Abstract A novel UDP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.