公开(公告)号：ES2172655T3

公开(公告)日：2002-10-01

申请号：ES96907412

申请日：1996-03-09

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  RIEGER JENS ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/20 ,  A61K9/16 ,  A61K47/30

公开(公告)号：PT857062E

公开(公告)日：2002-09-30

申请号：PT96937214

申请日：1996-10-23

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  ZETTLER HANS DIETER ,  BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  SCHIESSL MICHAEL

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：PT814781E

公开(公告)日：2002-07-31

申请号：PT96907412

申请日：1996-03-09

Applicant: BASF AG

Inventor： SANNER AXEL ,  ROSENBERG JOERG ,  BREITENBACH JORG ,  RIEGER JENS

IPC: A61K9/20 ,  A61K9/16 ,  A61K47/30

公开(公告)号：AU748772B2

公开(公告)日：2002-06-13

申请号：AU8632298

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  NEUMANN JOERG ,  LIEPOLD BERND ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  BREITENBACH JOERG ,  VOLLGRAF CHRISTIANE

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61K31/19

Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.

公开(公告)号：DK0697867T3

公开(公告)日：2002-03-11

申请号：DK94917601

申请日：1994-05-09

Applicant: BASF AG

Inventor： SANNER AXEL ,  ROSENBERG JOERG ,  GRABOWSKI SVEN ,  MUELLER WINFRIED ,  BINDER RUDOLF

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433 ,  A61K47/30 ,  A61K47/38

Abstract: PCT No. PCT/EP94/01489 Sec. 371 Date Nov. 7, 1995 Sec. 102(e) Date Nov. 7, 1995 PCT Filed May 9, 1994 PCT Pub. No. WO94/26267 PCT Pub. Date Nov. 24, 1994Compositions in the form of solid solutions containing a) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance and b) 10-99% by weight of at least one water-soluble polymer B as carrier substance.

公开(公告)号：GR3036716T3

公开(公告)日：2001-12-31

申请号：GR20010401573

申请日：2001-09-26

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  ROSENBERG JOERG

IPC: A61K9/20 ,  A61K47/04 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00

Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture ofa) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30,b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, andc) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium,where the stated amounts are based on the total of components a), b) and c).

公开(公告)号：BRPI0009299A

公开(公告)日：2001-12-18

申请号：BRPI0009299

申请日：2000-03-17

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BERNDL GUNTHER ,  LIEPOLD BERND ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K47/10 ,  A61K9/20 ,  A61K47/14 ,  A61K47/34 ,  A61P31/10 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

Abstract: "formas de administração farmacêutica mecanicamente estável para administração oral, e, processo para produzir formas de administração farmacêutica mecanicamente estável". a invenção diz respeito à formas de formas de administração farmacêutica mecanicamente estáveis para a administração peroral, que além de um ou mais ingredientes ativos e pelo menos um auxiliar formador de matriz termoplasticamente moldável, contêm mais do que 10 e até 40 % em peso de uma substância ativa de superfície que tenha um hlb entre 2 e 18 e seja líquida a 20 c ou tenha um ponto de gotejamento entre 20 e 50 c.

公开(公告)号：DE59509563D1

公开(公告)日：2001-10-04

申请号：DE59509563

申请日：1995-04-05

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/22

Abstract: Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range from 0.5 to 4 mm, composed ofa) 0.1-87% by weight of at least one biologically active compound,b) 5-50% by weight of at least one water-insoluble polymer,c) 5-45% by weight of at least one lipophilic component as plasticizer for polymer b),d) 3-40% by weight of a natural or semisynthetic gel former,e) 0-50% by weight of one or more conventional formulation aids.

公开(公告)号：AT204749T

公开(公告)日：2001-09-15

申请号：AT97901537

申请日：1997-01-17

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  ROSENBERG JOERG

IPC: A61K47/04 ,  A61K9/20 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00

Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture ofa) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30,b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, andc) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium,where the stated amounts are based on the total of components a), b) and c).

公开(公告)号：DE59605848D1

公开(公告)日：2000-10-12

申请号：DE59605848

申请日：1996-03-09

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30

Abstract: PCT No. PCT/EP96/01021 Sec. 371 Date Sep. 16, 1997 Sec. 102(e) Date Sep. 16, 1997 PCT Filed Mar. 9, 1996 PCT Pub. No. WO96/29053 PCT Pub. Date Sep. 26, 1996Transparent rapid release active substance compositions obtainable by extrusion of melts, containing non-steroidal analgesics, homopolymers of N-vinylpyrrolidone, saccharides or sugar alcohols and sodium or potassium salts.