公开(公告)号：ES2225531T3

公开(公告)日：2005-03-16

申请号：ES01929289

申请日：2001-03-29

Applicant: INFINEON TECHNOLOGIES AG

Inventor： FREY ALEXANDER ,  THEWES ROLAND

IPC: G01N27/30 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/22 ,  G01N27/327 ,  G01N27/403 ,  G01N27/416 ,  G01N27/49 ,  G01N33/487

Abstract: Biosensor, u con un primer electrodo que presenta una zona de sujeción para el inmovilizado de moléculas de sonda, que pueden enlazar biopolímeros macromoleculares, u con un segundo electrodo, u en el que el primer electrodo y/o el segundo electrodo está/están subdividido/s en una pluralidad de segmentos de electrodo aislados eléctricamente entre sí, con medios para el acoplamiento eléctrico independiente entre sí, de segmentos de electrodo seleccionados a voluntad, de modo que es ajustable una superficie de electrodo efectiva en su tamaño, dependiendo de los segmentos de electrodos seleccionados.

公开(公告)号：AT268902T

公开(公告)日：2004-06-15

申请号：AT01929289

申请日：2001-03-29

Applicant: INFINEON TECHNOLOGIES AG

Inventor： FREY ALEXANDER ,  THEWES ROLAND

IPC: G01N27/30 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/22 ,  G01N27/327 ,  G01N27/403 ,  G01N27/416 ,  G01N27/49 ,  G01N33/487

Abstract: The invention relates to a first electrode that is provided with a holding area for holding probe molecules which can bind macro-molecular biopolymers. The first electrode and/or a second electrode is/are divided into a plurality of electrode segments that are electrically insulated from one another. The randomly selected electrode segments, independently from one another, can be electrically coupled in such a way that an effective electrode surface can be adjusted in the size thereof according to the selected electrode segments.

公开(公告)号：DE10254158A1

公开(公告)日：2004-06-09

申请号：DE10254158

申请日：2002-11-20

Applicant: INFINEON TECHNOLOGIES AG

Inventor： SCHULZ THOMAS ,  JENKNER MARTIN ,  LYKEN JOHANNES ,  THEWES ROLAND

IPC: G01N27/414 ,  G01N33/487 ,  G01N33/50 ,  C12M1/34 ,  G01N33/483

Abstract: Sensor system for detecting signals from biological cells (24) comprises a semiconductor substrate (SUB) with an upper surface (26) on which the cells are placed. The substrate contains a field effect transistor whose channel has a coupling component connecting it to a sensor surface (16). Sensor system for detecting signals from biological cells (24) comprises a semiconductor substrate (SUB) with an upper surface (26) on which the cells are placed. The substrate contains a field effect transistor whose channel has a coupling component connecting it to a sensor surface (16). The normal to the sensor surface is at an angle to the normal to the upper surface of the substrate. The coupling component allows the conductivity of the channel to be affected by signals from the cells, using capacitive coupling. An Independent claim is included for a method for detecting electrical signals from biological cells using the sensor system

公开(公告)号：DE10228124A1

公开(公告)日：2004-01-29

申请号：DE10228124

申请日：2002-06-24

Applicant: INFINEON TECHNOLOGIES AG

Inventor： THEWES ROLAND ,  SCHIENLE MEINRAD ,  PAULUS CHRISTIAN ,  FREY ALEXANDER ,  HOLZAPFL BIRGIT ,  HOFMANN FRANZ

IPC: G01N27/403 ,  G01N33/487 ,  G01N33/50 ,  C12Q1/68 ,  G01N27/416 ,  G01N33/48

Abstract: Biosensor array (700) comprising a substrate (601), on which biosensors (602) are mounted which have two connectors, is new. One of these (603) is connected to a control lead (605) while the other (604) is connected to a detector lead (606). A control unit supplies a signal to the desired biosensor and the detector lead feeds the signal produced by it to a processor. Independent claims are also included for: (a) a similar array in which control and detector leads are both replaced by signal leads (b) a method for operating the array with control and detector leads; and (c) a method for operating the array with signal leads.

公开(公告)号：DE10224567A1

公开(公告)日：2003-12-18

申请号：DE10224567

申请日：2002-06-03

Applicant: INFINEON TECHNOLOGIES AG

Inventor： THEWES ROLAND ,  PAULUS CHRISTIAN ,  SCHIENLE MEINRAD ,  FREY ALEXANDER

IPC: C12M1/00 ,  C12Q1/68 ,  G01N1/00 ,  G01N27/02 ,  G01N33/50 ,  G01N27/22 ,  G01R27/02 ,  G01R27/26

Abstract: Sensor arrangement having capture molecules immobilized on any of three sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules; a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes; a detection device, wherein in a first operating state a reference liquid is introduced into the sensor arrangement and a reference value of an electrical signal is detected at the selected sensor electrode, and in a second operating state an analyte possibly having molecules to be detected is introduced into the sensor arrangement and a sensor value of the electrical signal is detected at the selected sensor electrode; and an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.

公开(公告)号：DE10214719A1

公开(公告)日：2003-11-20

申请号：DE10214719

申请日：2002-04-03

Applicant: INFINEON TECHNOLOGIES AG

Inventor： PAULUS CHRISTIAN ,  THEWES ROLAND ,  FREY ALEXANDER

IPC: C12Q1/68 ,  G01N33/543 ,  G01N33/50

公开(公告)号：DE10211900A1

公开(公告)日：2003-10-16

申请号：DE10211900

申请日：2002-03-18

Applicant: INFINEON TECHNOLOGIES AG

Inventor： HANEDER THOMAS ,  THEWES ROLAND ,  SCHMID GUENTER ,  KLAUK HAGEN

IPC: G01N27/414 ,  G01N33/543 ,  H01L27/28 ,  H01L51/05 ,  G01N33/50 ,  C12Q1/68 ,  G01N33/68

公开(公告)号：DE10203996A1

公开(公告)日：2003-08-21

申请号：DE10203996

申请日：2002-02-01

Applicant: INFINEON TECHNOLOGIES AG

Inventor： FREY ALEXANDER ,  PAULUS CHRISTIAN ,  THEWES ROLAND

IPC: G01R19/12 ,  G01N27/414 ,  G01N27/416 ,  G01N33/53 ,  G01N33/543 ,  G01N37/00 ,  G01R19/165 ,  C12Q1/68 ,  G01N33/50

Abstract: The invention relates to a circuit arrangement (100), a redox recycling sensor, a sensor assembly and a method for processing a current signal that is provided by a sensor electrode. Said circuit arrangement (100) comprises has a sensor electrode (101), a control circuit (102), which is coupled to the sensor electrode via an input (103) and a current source (104), which is coupled to a control output (106) of the control circuit via its control input (105), in such a way that the current source can be controlled by said control circuit and which is coupled to the sensor electrode via its output. The control circuit is configured in such a way that if the current signal (108) that flows into the control circuit via its input lies outside a predetermined current intensity range, the control circuit controls the current source in such a way that the latter adjusts the current (109) it generates, in order to obtain a predetermined current intensity value for the electric current flowing into the control circuit input. If the current that flows into the control circuit via its input lies within the predetermined current intensity range, the control circuit controls the current source in such a way that the latter maintains the current it generates at the current value. In addition, the circuit arrangement has a detection unit (110), which detects the fact that the current signal flowing into the control circuit via its input lies outside the predetermined current intensity range.

公开(公告)号：DE10127960A1

公开(公告)日：2002-12-19

申请号：DE10127960

申请日：2001-06-08

Applicant: SIEMENS AG ,  INFINEON TECHNOLOGIES AG

Inventor： GUMBRECHT WALTER ,  THEWES ROLAND

IPC: B01L3/00 ,  B81B7/00 ,  B81B7/04 ,  G01N33/487 ,  G01N37/00

Abstract: Wafer arrangement, comprising: (1) a number of chips (101) arranged on a wafer (100); (2) electrical connections (108) between at least two chips; and (3) a control unit (102) coupled to and for controlling at least one part of the chips, where at least one part of the chips has at least one electrical switch, and the electrical connections are at least partly attached to the wafer, is new. An Independent claim is also included for a process for producing the above wafer arrangement.

公开(公告)号：DE10125018A1

公开(公告)日：2002-12-05

申请号：DE10125018

申请日：2001-05-22

Applicant: INFINEON TECHNOLOGIES AG

Inventor： WEBER WERNER ,  THEWES ROLAND ,  LEHMANN VOLKER

IPC: C12Q1/68 ,  C12Q1/6825 ,  G01N11/04 ,  G01N11/16 ,  G01N33/543 ,  G01N33/50

Abstract: Detecting (M1) molecules in a liquid (102) comprising: (a) fixing receptor molecules to an immobilizing region (101) of a substrate (100); (b) determining the flow characteristics of a reference liquid over this region; (c) measuring the flow characteristics of the liquid to be analyzed over the same region; and (d) thus determining whether substances have bonded to the receptor molecules, is new. An Independent claim is also included for a sensor system, used in (M1).