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    2.
    发明专利
    未知

    公开(公告)号：DE10130218A1

    公开(公告)日：2003-01-09

    申请号：DE10130218

    申请日：2001-06-22

    Applicant: INFINEON TECHNOLOGIES AG

    Inventor： JENKNER MARTIN ,  PAULUS CHRISTIAN ,  LEHMANN VOLKER

    IPC: G01N37/00 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  B81B1/00 ,  G01N35/10 ,  C12M1/34

    Abstract: The invention relates to a device, especially for patch-clamping vesicles and/or for dispensing small, defined liquid amounts onto surfaces. The device is characterized in that in a substrate (2) at least one pipette in the form of a through hole (8) with a predetermined diameter is produced, a rim (16) of the through hole (8) protruding from a neighboring surface (4) of the substrate (2) by a predetermined length. The invention further relates to a method for producing the device, comprising the following steps: producing at least one hole (8), forming at least one modified surface layer (12) on at least the inner surfaces of the hole (8), selectively removing the substrate (2), the modified surface layer (12) not being substantially affected so that it protrudes from a surface (4) of the substrate and forms a protruding rim (16), and finishing the hole (8) as a through hole in a suitable process step.

    4.
    发明专利
    未知

    公开(公告)号：DE10128574A1

    公开(公告)日：2003-01-02

    申请号：DE10128574

    申请日：2001-06-13

    Applicant: INFINEON TECHNOLOGIES AG

    Inventor： JENKNER MARTIN ,  THEWES ROLAND

    IPC: B01L3/00 ,  C12M1/12 ,  C12M1/20 ,  C12M3/00 ,  B01L3/02 ,  C12N15/00

    Abstract: The invention relates to a device for handling, especially for positioning, selecting, transporting and/or fixing, vesicles (10) by means of a sieve element (6; 16; 26) comprising a plurality of pores (8; 28) for respectively receiving preferably a single vesicle (10), said pores (8; 28) having a pre-determined size and being arranged at pre-determined distances in relation to each other. The invention also relates to a method for handling and positioning vesicles (10). The vesicles (10) are supplied, in a solution, to a sieve element (6; 16; 26) in which pores (8; 28) are formed for receiving preferably single vesicles (10), the individual pores (8; 28) having a pre-determined size and position in the sieve element (6; 16; 26), and the vesicles (10) are deposited in the pores (8; 28).

    6.
    发明专利
    未知

    公开(公告)号：DE10151020A1

    公开(公告)日：2003-04-30

    申请号：DE10151020

    申请日：2001-10-16

    Applicant: INFINEON TECHNOLOGIES AG

    Inventor： THEWES ROLAND ,  PAULUS CHRISTIAN ,  JENKNER MARTIN ,  EVERSMANN BJOERN

    IPC: G01N27/414 ,  G01N33/487 ,  H03F3/45 ,  G01N33/48

    Abstract: The invention relates to a circuit arrangement, a sensor array and a biosensor array. The circuit arrangement comprises a substrate, a sensor element configured on a surface area of the substrate with a physical parameter which can be coupled to a substance to be analyzed; The type of coupling comprises a resistive component and a calibrating device embodied in or on the substrate and arranged in such a way that a modification of the value of the physical parameter of the sensor element can be at least partially compensated therewith. Preferably, the sensor element of the circuit arrangement is provided with an electrically conductive sensor electrode which can be coupled to the substance to be analyzed. The sensor element can also comprise a measuring transistor with a gate connection which is coupled to the electrically conductive sensor electrode.

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