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公开(公告)号：ES2145838T3
公开(公告)日：2000-07-16
申请号：ES94927528
申请日：1994-09-01
Applicant: BASF AG , RHEIN BIOTECH PROZ & PROD GMBH
Inventor： SCHWEDEN JUERGEN , BOLLSCHWEILER CLAUS , PIONTEK MICHAEL , WEYDEMANN ULRIKE , JANOWICZ ZBIGNIEW A , STRASSER ALEXANDER W M
Abstract: PCT No. PCT/EP94/02897 Sec. 371 Date Mar. 1, 1996 Sec. 102(e) Date Mar. 1, 1996 PCT Filed Sep. 1, 1994 PCT Pub. No. WO95/07356 PCT Pub. Date Mar. 16, 1995A process for the recombinant production of proteins in the yeast Hansenula comprises transforming Hansenula with an expression cassette which comprises the following structural elements encoded: L-A-P-GEN where L is a leader sequence, A is an adaptor producing an alpha-helix structure, P is a processing signal and GEN is a structural gene for the required protein.
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公开(公告)号：DE59409341D1
公开(公告)日：2000-06-15
申请号：DE59409341
申请日：1994-10-17
Applicant: BASF AG , RHEIN BIOTECH PROZ & PROD GMBH
Inventor： SCHWEDEN JUERGEN , BOLLSCHWEILER CLAUS , PIONTEK MICHAEL , WEYDEMANN ULRIKE , GELLISSEN GERD
Abstract: A process for the recombinant production of proteins in yeast comprises transforming the yeast with an expression cassette which comprises the following structural elements encoded:L-A-P-GENwhere L is a leader sequence of an animal peptide neurohormone, A is an adaptor producing an alpha-helix structure, P is a processing signal and GEN is a structural gene for the required protein.
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公开(公告)号：HU9900574A2
公开(公告)日：1999-06-28
申请号：HU9900574
申请日：1997-02-11
Applicant: BASF AG
Inventor： BOLLSCHWEILER CLAUS , FRIEDRICH THOMAS , HOEFFKEN HANS WOLFGANG , RADITSCH MARTIN , RUEBSAMEN KLAUS , SCHMIDT MARTIN , SCHWEDEN JUERGEN
IPC: C12N15/09 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/04 , C07K14/47 , C12N9/74 , C12N15/00 , C12N15/57 , C12R1/91 , A61K38/48
Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.
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公开(公告)号：NO983677A
公开(公告)日：1998-08-11
申请号：NO983677
申请日：1998-08-11
Applicant: BASF AG
Inventor： RADITSCH MARTIN , FRIEDRICH THOMAS , BOLLSCHWEILER CLAUS , SCHMIDT MARTIN , H FFKEN HANS WOLFGANG , SCHWEDEN J RGEN , R BSAMEN KLAUS
IPC: C12N15/09 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/04 , C07K14/47 , C12N9/74 , C12N15/00 , C12N15/57 , C12R1/91 , A61K38/48
CPC classification number: C12N9/6429 , A61K38/00 , C12Y304/21005
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公开(公告)号：HRP950115A2
公开(公告)日：1997-10-31
申请号：HRP950115
申请日：1995-03-09
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROEGER BURGHARD , BIALOJAN SIEGRIED , BOLLSCHWEILER CLAUS , WERNET WOLFGANG , UNGER LILIANE , RESCHACK MANFRED
IPC: C07D251/26 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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Patent Agency Ranking
公开(公告)号：MX9604448A
公开(公告)日：1997-07-31
申请号：MX9604448
申请日：1995-03-23
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROGER BURKHARD , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , WERNER WOLFGANG
IPC: A61K31/00 , A61K31/505 , A61K31/506 , C07D251/26 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: El presente invento se refiere a uso de determinados derivados de ácido carboxílico como medicamentos. La endotelina es un péptido compuesto de 21 aminoácidos, que es sintetizado y liberado por el endotelio vascular. La endotelina existe en tres formas isomeras, ET-1, ET-2 y ET-3. En lo sucesivo, el término "endotelina" o "ET" abarcará una o varias formas isomeras en la endotelina. La endotelina es un vasoconstrictor potente y tiene un fuerte efecto sobre el tono vascular. Es sabido, que esta constriccion vascular es producida por el ligamiento de la endotelina con su receptor.
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127.发明专利
公开(公告)号：HUT75305A
公开(公告)日：1997-05-28
申请号：HU9602695
申请日：1995-03-23
Applicant: BASF AG
Inventor： BAUMANN ERNST , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , KLINGE DAGMAR , KROEGER BURKHARD , RASCHACK MANFRED , RHEINHEIMER JOACHIM , RIECHERS HARTMUT , UNGER LILIANE , VOGELBACHER UWE JOSEF , WERNET WOLFGANG
IPC: C07D251/26 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：PL316563A1
公开(公告)日：1997-01-20
申请号：PL31656395
申请日：1995-03-23
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROEGER BURKHARD , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: A61K31/00 , A61K31/505 , C07D251/26 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：NO964121L
公开(公告)日：1996-11-26
申请号：NO964121
申请日：1996-09-27
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROGER BURKHARD , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: A61K31/00 , C07D251/26 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：MX9205978A
公开(公告)日：1993-04-01
申请号：MX9205978
申请日：1992-10-16
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , KUENAST CHRISTOPH
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