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    ｐＨ 민감성 블록공중합체를 이용한 약물전달체 제조 및응용
    131.
    发明公开
    ｐＨ 민감성 블록공중합체를 이용한 약물전달체 제조 및응용 无效
    使用PH-敏感性嵌段共聚物及其应用制备药物输送系统

    公开(公告)号：KR1020080095130A

    公开(公告)日：2008-10-28

    申请号：KR1020070039524

    申请日：2007-04-23

    Applicant: 한국과학기술연구원

    Inventor： 권익찬 ,  이두성 ,  김광명 ,  김봉섭 ,  박경순 ,  김민상 ,  한종권 ,  고진영

    IPC: A61K9/52 ,  A61P35/00

    CPC classification number: A61K9/5089 ,  A61K9/5031

    Abstract: A drug delivery system is provided to be easily disintegrated at low pH of a topical portion of various cancers or inflammatory diseases due to high sensitivity on the pH and decrease toxicity of a drug itself, thereby releasing a large amount of a drug into the diseased portion selectively to enhance therapeutic effect of the drug and being useful for treating various cancers or inflammatory diseases. A drug delivery system consists of a pH-sensitive block copolymer encapsulating a hydrophobic drug therein and having a hydrophilic moiety and a hydrophobic moiety, wherein the hydrophilic moiety is polyethylene glycol, poly(N-2-(hydroxypropyl)methacrylamide), poly(divinyl ether-co-maleic anhydride) or poly(styreneco-maleic anhydride), the hydrophobic moiety is poly(beta-amino ester)(PAE), poly(amido amine)(PAA) or a copolymer thereof(PAEA), and the drug is an anti-cancer agent selected from the group consisting of paclitaxel, doxorubicin, retinoic acid, cis-platin, camptothecin, 5-FU, docetaxel, tamoxifen, anasterozole, carboplatin, topotecan, belotecan, irinotecan, gleevec and vincristine or an anti-inflammatory agent selected from the group consisting of aspirin, salicylates, ibuprofen, naproxen, fenoprofen, indomethacin, phenyltazone, methotrexate, cyclophosphamide, mechlorethamine, dexamethasone, prednisolone, celecoxib, valdecoxib, nimesulide, cortisone and corticosteroid.

    Abstract translation: 提供了药物递送系统，由于对pH高的敏感性和药物本身的毒性降低，因此容易在各种癌症或炎性疾病的局部部分的低pH下崩解，从而将大量药物释放到患病部位 选择性地增强药物的治疗效果并且可用于治疗各种癌症或炎性疾病。 药物递送系统由在其中封装疏水性药物并具有亲水部分和疏水部分的pH敏感性嵌段共聚物组成，其中亲水部分是聚乙二醇，聚（N-2-（羟丙基）甲基丙烯酰胺），聚（二乙烯基 醚 - 共 - 马来酸酐）或聚（苯乙烯 - 顺丁烯二酸酐），疏水部分是聚（β-氨基酯）（PAE），聚（酰氨基胺）（PAA）或其共聚物（PAEA） 是选自紫杉醇，多柔比星，视黄酸，顺铂，喜树碱，5-FU，多西紫杉醇，他莫昔芬，西曲唑，卡铂，托泊替康，美沙替丹，伊立替康，格列卫和长春新碱或抗生素的抗癌剂， 选自阿司匹林，水杨酸酯，布洛芬，萘普生，非诺洛芬，吲哚美辛，苯那唑，甲氨蝶呤，环磷酰胺，氮芥，地塞米松，泼尼松龙，塞来考昔，伐地考昔，尼美舒利，可的松和皮质类固醇的炎症剂。

    단백질 분해효소 검출 및 생체 내 영상화를 위한 금속 나노입자 및 그것의 용도
    132.
    发明授权
    단백질 분해효소 검출 및 생체 내 영상화를 위한 금속 나노입자 및 그것의 용도 失效
    一种基于金属纳米材料的蛋白成像探针及其应用

    公开(公告)号：KR100857770B1

    公开(公告)日：2008-09-09

    申请号：KR1020070035722

    申请日：2007-04-11

    Applicant: 한국과학기술연구원

    Inventor： 권익찬 ,  최귀원 ,  김광명 ,  안철희 ,  윤인찬 ,  이슬기 ,  박경순

    IPC: C01G23/04 ,  C04B35/465 ,  B82B3/00

    CPC classification number: A61K49/0056 ,  A61K49/0032 ,  A61K49/0065 ,  A61K49/0093 ,  C12Q1/37

    Abstract: A gold nanoparticle of peptide and cyanine phosphor is provided to selectively in vivo detect and image protease, and quantitatively analyze the expression amount of protease, so that the gold nanoparticle is useful as a sensor for realtime cell imaging and early diagnosis of non-hygroscopic disease by being selectively absorbed into the cell or tissue. A gold nanoparticle for imaging MMP(matrix metalloprotease) expressed in the cell or tissue contains a peptide with -SH end group which is specifically degraded by MMP coupled with a cyanine phosphor, wherein the peptide with -SH end group is Gly-Pro-Leu-Gly-Leu-Phe-Ala-Arg-Cys; and the MMP is MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, MMP-17, MMP-18, MMP-19, MMP-20, MMP-21, MMP-22, MMP-23, MMP-24, MMP-25, MMP-26, MMP-27 or MMP-28.

    Abstract translation: 提供肽和花青荧光体的金纳米颗粒以选择性体内检测和图像蛋白酶，并定量分析蛋白酶的表达量，使得金纳米颗粒可用作实时细胞成像和非吸湿性疾病早期诊断的传感器 通过选择性地吸收到细胞或组织中。 用于成像在细胞或组织中表达的MMP（基质金属蛋白酶）的金纳米颗粒含有具有-SH端基的肽，其通过与花青磷光体偶联的MMP特异性降解，其中具有-SH端基的肽是Gly-Pro-Leu -Gly-LEU-PHE-ALA-精氨酸 - 半胱氨酸; MMP-1，MMP-2，MMP-3，MMP-7，MMP-8，MMP-9，MMP-10，MMP-11，MMP-12，MMP-13， 15，MMP-16，MMP-17，MMP-18，MMP-19，MMP-20，MMP-21，MMP-22，MMP-23，MMP-24，MMP-25，MMP-26， MMP-28。

    고분자-지질 조성물, 구조체 및 이들의 제조방법
    134.
    发明授权
    고분자-지질 조성물, 구조체 및 이들의 제조방법 失效
    聚合物混合物的组合物及其制备方法及其制备方法

    公开(公告)号：KR100663880B1

    公开(公告)日：2007-01-03

    申请号：KR1020040009336

    申请日：2004-02-12

    Applicant: 한국과학기술연구원

    Inventor： 정혜선 ,  정서영 ,  권익찬 ,  이수연 ,  노경호

    IPC: A61L27/44 ,  C08L67/04 ,  A61L27/56 ,  C12M3/00 ,  A61L15/10 ,  A61F13/00

    Abstract: 본 발명은 유기용매에 녹는 한 가지 이상의 생체적합성 결정성 고분자와 한 가지 이상의 중성지질이 유기용매에 균일하게 용해되어 있고, 0.05 내지 14 중량%의 생체적합성 결정성 고분자, 0.1 내지 14 중량%의 중성지질 및 나머지 분량의 유기용매를 포함하는 고분자-지질 조성물, 상기 고분자-지질 조성물로부터 유기용매 또는 유기용매와 지질을 제거하여 얻어지는 고분자-지질 복합 구조체 또는 고분자 구조체, 및 이들의 제조방법에 관한 것이다.

    생리활성물질 또는 약물을 효과적으로 전달하는 요오드화오일 계열 지방유제 및 그 제조방법
    139.
    发明公开
    생리활성물질 또는 약물을 효과적으로 전달하는 요오드화오일 계열 지방유제 및 그 제조방법 失效
    用于有效输送生理活性物质或药物及其生产的基于油的脂肪乳剂

    公开(公告)号：KR1020030071373A

    公开(公告)日：2003-09-03

    申请号：KR1020020011040

    申请日：2002-02-28

    Applicant: 한국과학기술연구원

    Inventor： 정서영 ,  권익찬 ,  정혜선 ,  김영진

    IPC: A61K9/107

    CPC classification number: A61K9/107 ,  A61K47/24 ,  A61K47/34 ,  A61K47/44 ,  A61K47/543 ,  C12Q1/34

    Abstract: PURPOSE: A process of preparing a fat emulsion using oils having higher specific gravity than water as a fat emulsion base material and amphoteric surfactants as an emulsifier is provided. The fat emulsion exhibits excellent expression efficiency in adhesive cell lines as well as in the presence of serum as compared to conventional liposome or squalane-based fat emulsion formulation and thus permits easy in-vitro assay of gene expression efficiency. CONSTITUTION: A fat emulsion comprises: 2 to 30% by weight of oil mixtures comprising iodized oil and one or more glyceride-based oils such as squalene or squalane as a fat emulsion base; 0.01 to 40% by weight of one or more amphoteric surfactants; 0.01 to 10% by weight of hydrophilic polymers, phospholipid combined with hydrophilic polymers or polymerizable phospholipid; 0.01 to 10% by weight of glycerol, soluble peptide or soluble protein; and the balance comprising water. The oil mixtures contain 40% by weight of iodized oil selected from the group consisting of iodized poppy seed oil.

    Abstract translation: 目的：提供使用比水重量大的油作为脂肪乳液基质和作为乳化剂的两性表面活性剂制备脂肪乳剂的方法。 与常规脂质体或基于角鲨烷的脂肪乳剂制剂相比，脂肪乳剂在粘合细胞系以及血清存在下表现出优异的表达效率，因此允许容易的体外测定基因表达效率。 构成：脂肪乳液包含：2至30重量％的包含碘化油和一种或多种甘油酯基油如角鲨烯或角鲨烷作为脂肪乳液基质的油混合物; 0.01〜40重量％的一种或多种两性表面活性剂; 亲水性聚合物0.01〜10重量％，与亲水性聚合物或聚合性磷脂结合的磷脂; 甘油0.01〜10％，可溶性肽或可溶性蛋白质; 余量包括水。 油混合物含有40重量％的选自碘化罂粟籽油的碘化油。

    폐렴구균성 표면 접착단백질의 가용화용 조성물, 가용화용액상제형, 및 가용화용 분말제형, 이들 각각의 제조방법및 백신
    140.
    发明公开
    폐렴구균성 표면 접착단백질의 가용화용 조성물, 가용화용액상제형, 및 가용화용 분말제형, 이들 각각의 제조방법및 백신 失效
    溶解氧气表面蛋白的组合物，溶解液体制剂，溶解粉末制剂，其制备及其疫苗

    公开(公告)号：KR1020030028672A

    公开(公告)日：2003-04-10

    申请号：KR1020010059365

    申请日：2001-09-25

    Applicant: 한국과학기술연구원

    Inventor： 정서영 ,  권익찬 ,  정혜선

    IPC: A61K9/10

    CPC classification number: A61K9/107 ,  A61K9/08 ,  A61K9/19 ,  A61K39/09 ,  A61K47/14 ,  A61K47/24

    Abstract: PURPOSE: Provided is a process of preparing a solubilizing composition which is used as an effective vaccine by solubilizing a pneumococcal surface protein A(PspA) as an antigenic protein and stably delivers it to a desired position in the body. Therefore, the composition can be an effective vaccine which induces protective immunity in an infant as well as an adult. CONSTITUTION: The solubilizing composition of PspA contains 0.001 to 2% by weight of PspA as an effective component, 9 to 90% by weight of one or more monogylceride-based compounds, 0.01 to 90% by weight of one or more emulsifiers, 0.01 to 10% by weight of water or an aqueous solution and 0.001 to 5% by weight of an organic solvent.

    Abstract translation: 目的：提供一种通过溶解肺炎球菌表面蛋白A（PspA）作为抗原蛋白并稳定地将其递送至体内所需位置而用作有效疫苗的增溶组合物的方法。 因此，组合物可以是在婴儿和成年人中诱导保护性免疫的有效疫苗。 构成：PspA的增溶组合物含有0.001〜2重量％的PspA作为有效成分，9〜90重量％的一种或多种单甘油酯类化合物，0.01〜90重量％的一种或多种乳化剂，0.01〜 10重量％的水或水溶液和0.001〜5重量％的有机溶剂。

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