公开(公告)号：FI973360A0

公开(公告)日：1997-08-15

申请号：FI973360

申请日：1997-08-15

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  C07K

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：HU9603474D0

公开(公告)日：1997-02-28

申请号：HU9603474

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HORNBERGER WILFRIED ,  HOEFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：NO965412L

公开(公告)日：1997-02-14

申请号：NO965412

申请日：1996-12-16

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN WOLFGANG HANS ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：FI965039A0

公开(公告)日：1996-12-16

申请号：FI965039

申请日：1996-12-16

Applicant: BASF AG

Inventor： BUEHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07K

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：CA2210989A1

公开(公告)日：1996-08-15

申请号：CA2210989

申请日：1996-02-06

Applicant: BASF AG

Inventor： HORNBERGER WILFRIED ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  MACK HELMUT ,  H FFKEN HANS WOLFGANG ,  B HM HANS-JOACHIM ,  KOSER STEFAN

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087 ,  A61K38/05

Abstract: The invention concerns thrombin inhibitors of formula (I), wherein R1, A, B, and D have the meanings given in the description, and intermediate products for the preparation thereof. The compounds of formula (I) are suitable for combating diseases.

公开(公告)号：CA2207874A1

公开(公告)日：1996-06-13

申请号：CA2207874

申请日：1995-11-25

Applicant: BASF AG

Inventor： SEITZ WERNER ,  PFEIFFER THOMAS ,  MACK HELMUT ,  KOSER STEFAN ,  HORNBERGER WILFRIED ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  BOEHM HANS-JOACHIM

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

Abstract: The invention pertains to compounds of formula (I), wherein R1, A and B are as indicated in the description, and to their preparation. The new compounds can be used for combatting diseases.

公开(公告)号：CA1337991C

公开(公告)日：1996-01-23

申请号：CA554039

申请日：1987-12-10

Applicant: BASF AG

Inventor： SEITZ WERNER ,  UNGER LILIANE ,  RASCHACK MANFRED ,  BALDINGER VERENA ,  RUEBSAMEN KLAUS ,  GRIES JOSEF

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/37 ,  C07C255/42 ,  C07C255/53 ,  C07C255/58 ,  C07D317/50 ,  C07D317/60 ,  C07D319/08 ,  C07D319/18 ,  C07D321/00

Abstract: Disclosed are basically substituted phenylacetonitriles where R1, R2 and R3 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl, nitro or C1-C4-alkoxy, and two radicals in adjacent positions may furthermore together form a methylenedioxy, ethylenedioxy, 1,3-dioxatetramethylene, propylene or butylene group, R4 is a saturated or unsaturated alkyl or cycloalkyl group of not more than 8 carbon atoms or phenyl, R5 is hydrogen or C1-C4-alkyl, R6 is a saturated or unsaturated hydrocarbon radical of 6 to 15 carbon atoms which may contain a ring, and n is 2, 3 or 4. These compounds are useful for the treatment of disorders, such as cardiovascular disorders, in particular coronary heart disease, vasospasms, cerebral ischemia, hypertension and circulatory shock. They can also be used for the prophylaxis and therapy of gastric and duodenal ulcers and asthmatic disorders.

公开(公告)号：DE58908571D1

公开(公告)日：1994-12-01

申请号：DE58908571

申请日：1989-08-01

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  KOENIG HORST ,  SCHLICK ERICH ,  SEITZ WERNER

IPC: A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/14 ,  A61P35/00 ,  C07C255/42 ,  C07C255/43

公开(公告)号：AT113206T

公开(公告)日：1994-11-15

申请号：AT89908428

申请日：1989-08-01

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  KOENIG HORST ,  SCHLICK ERICH ,  SEITZ WERNER

IPC: A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/14 ,  A61P35/00 ,  C07C255/42 ,  C07C255/43

公开(公告)号：MX9203399A

公开(公告)日：1992-07-01

申请号：MX9203399

申请日：1992-06-25

Applicant: BASF AG

Inventor： SEITZ WERNER ,  TESCHENDORF HANS-JUERGEN ,  MICHEL ALFRED ,  TRAUT MARTIN ,  HOFMANN HANS PETER ,  KRELSKOTT HORST

IPC: C07C211/58