公开(公告)号：MX9701969A

公开(公告)日：1998-02-28

申请号：MX9701969

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20 ,  A61K09/127

Abstract: Se describe un recipiente que comprende una suspension acuosa de lípidos y una fase gaseosa que se separa substancialmente de la fase acuosa de estabilizacion,util en formacion de imágenes de diagnostico tales como formacion de imágenes de ultrasonido y resonancia magnética y en aplicaciones terapéuticas.

公开(公告)号：AU687690B2

公开(公告)日：1998-02-26

申请号：AU7048096

申请日：1996-10-29

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: G01R33/28 ,  A61B5/055 ,  A61K49/00 ,  A61K49/06 ,  A61K49/12 ,  A61K49/18 ,  C08L71/02 ,  A61K47/34 ,  A61K31/725

Abstract: Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents such as paramagnetic, superparamagnetic or proton density contrast agents. Additionally, the polymers or polymer and contrast agent admixtures may be mixed with one or more biocompatible gases to increase the relaxivity of the resultant preparation, and/or with other components. In a preferable embodiment, the contrast medium is hypoosmotic.

公开(公告)号：AU3313197A

公开(公告)日：1998-01-07

申请号：AU3313197

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02 ,  A61B5/055

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：CA2252617A1

公开(公告)日：1997-11-06

申请号：CA2252617

申请日：1997-04-30

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS

IPC: C12N15/09 ,  A61K9/127 ,  A61K41/00 ,  A61K45/08 ,  A61K47/02 ,  A61K47/18 ,  A61K47/30 ,  A61K47/42 ,  A61K48/00 ,  A61P3/10 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P21/00 ,  A61P31/18 ,  A61P35/00 ,  C12N5/10 ,  C12N15/87 ,  C12N15/88 ,  C12P21/02 ,  A61K49/00 ,  A61M37/00 ,  A61N7/00 ,  A61K51/04 ,  A61K47/06 ,  A61K31/70 ,  C12N15/85

Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.

公开(公告)号：CA2220756A1

公开(公告)日：1996-12-12

申请号：CA2220756

申请日：1996-05-24

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  YELLOWHAIR DAVID W

IPC: A61B18/00 ,  A61B8/00 ,  A61B8/08 ,  A61B8/12 ,  A61K41/00 ,  A61K49/22 ,  A61N7/00 ,  G01S15/89 ,  G06T1/00

Abstract: Methods and apparatus (12-102) for performing diagnostic ultrasound simultaneously with the application of therapeutic ultrasonic waves are disclosed. The methods and apparatus (12-102) are particularly advantageous in performing ultrasonic imaging of a region of a patient while simultaneously applying therapeutic ultrasonic waves to the region for the purpose of rupturing vesicles administered to that region for purposes such as enhanced cavitation or the targeted release of a bioactive agent into the region. An operator is able to monitor the rupture of vesicles in real time.

公开(公告)号：AU5184496A

公开(公告)日：1996-10-02

申请号：AU5184496

申请日：1996-03-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/00 ,  A61B5/055 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  G01R33/28 ,  G01R33/561 ,  A61B8/00 ,  A61B8/13 ,  A61K9/66 ,  A61K49/04

公开(公告)号：CA2214855A1

公开(公告)日：1996-09-19

申请号：CA2214855

申请日：1996-03-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/00 ,  A61B5/055 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  G01R33/28 ,  G01R33/561 ,  A61N7/00

Abstract: A novel method of magnetic resonance focused surgical ultrasound by administering to a patient a magnetic resonance imaging (MRI) contrast medium comprising gas filled vesicles, then scanning the patient with MRI techniques, and then applying ultrasound to effect surgery. These methods may also use an MRI contrast medium comprising gaseous precursor filled vesicles which undergo a phase transition from a liquid to gas in vivo after administration. Additionally, the MRI contrast medium may comprise a therapeutic compound.

公开(公告)号：CA2213417A1

公开(公告)日：1996-08-29

申请号：CA2213417

申请日：1996-01-29

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： WU GUANLI ,  SHEN DEKANG ,  UNGER EVAN C

IPC: C12N15/09 ,  A61K9/107 ,  A61K9/127 ,  A61K38/00 ,  A61K47/14 ,  A61K47/16 ,  A61K48/00 ,  A61P37/04 ,  C07C237/10 ,  C07F9/10 ,  C07K14/135 ,  C07K14/50 ,  C12N15/88 ,  C07D259/00 ,  C07F9/09 ,  A61K9/10 ,  A61K47/48 ,  C07F9/50 ,  C07C323/60 ,  A61K31/70

Abstract: Cationic lipid compound which comprise at least two cationic groups. The cationic lipid compound are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, micelles and liposomes.

公开(公告)号：CA2200061A1

公开(公告)日：1996-03-21

申请号：CA2200061

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

公开(公告)号：AU2601395A

公开(公告)日：1995-12-18

申请号：AU2601395

申请日：1995-05-22

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/04 ,  A61K49/18

Abstract: Novel gas filled microspheres useful as computed tomography (CT) contrast agents. The microspheres are prepared from a gas and/or a gaseous precursor, and one or more stabilizing compounds.