公开(公告)号：CA1233465A

公开(公告)日：1988-03-01

申请号：CA469137

申请日：1984-12-03

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  VON PHILIPSBORN GERDA ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12 ,  C07D207/335

Abstract: Aminopropanol derivatives of the formula I where R1 and R2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R1 and R2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and- is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4 yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, processes for their preparation, and antiarrhythmic agents containing these compounds.

公开(公告)号：FI74955B

公开(公告)日：1987-12-31

申请号：FI823762

申请日：1982-11-03

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO ,  SCHLECKER RAINER ,  FRANKE ALBRECHT ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  TESCHENDORF HANS-JUERGEN ,  KRETZSCHMAR ROLF ,  TRAUT MARTIN ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22

公开(公告)号：FI73425B

公开(公告)日：1987-06-30

申请号：FI822203

申请日：1982-06-18

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：DK149888B

公开(公告)日：1986-10-20

申请号：DK59281

申请日：1981-02-12

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRANKE ALBRECHT ,  LENKE DIETER ,  LEHMANN HANS DIETER ,  GRIES JOSEF

IPC: C07D413/12 ,  A61K31/495 ,  A61K31/496 ,  A61P9/12 ,  C07D271/10 ,  C07D405/12

Abstract: Novel phenylpiperazinylpropanols of 1,3,4-oxadiazolylphenols and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful in the treatment of hypertonia.

公开(公告)号：ZA855224B

公开(公告)日：1986-03-26

申请号：ZA855224

申请日：1985-07-11

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10 ,  C07D ,  A61K

Abstract: Novel pyrrol-1-ylphenyldihydropyridazinones of the formula I their preparation and their use in the treatment of disorders.

公开(公告)号：ZA8505224B

公开(公告)日：1986-03-26

申请号：ZA8505224

申请日：1985-07-11

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10 ,  C07D ,  A61K

CPC classification number: C07D403/04 ,  C07D403/10

公开(公告)号：NO852793A

公开(公告)日：1986-01-13

申请号：NO852793

申请日：1985-07-11

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10 ,  C07D

CPC classification number: C07D403/04 ,  C07D403/10

公开(公告)号：CS238634B2

公开(公告)日：1985-12-16

申请号：CS783782

申请日：1982-04-06

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS D ,  FRIEDRICH LUDWIG ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS J ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/66

公开(公告)号：CA1193601A

公开(公告)日：1985-09-17

申请号：CA381476

申请日：1981-07-09

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  WEIFENBACH HARALD ,  HOFMANN HANS P ,  KREISKOTT HORST

IPC: C07D295/08 ,  A61K31/495 ,  A61P9/12 ,  A61P25/20 ,  C07C45/70 ,  C07D295/092 ,  C07D303/22 ,  C07D295/04

Abstract: The present invention relates to indanone-oxyalkyl-piperazine derivatives and their addition salts with acids, the preparation of these compounds, and pharmaceutical formulations which contain these compounds and can be used as sedatives, transquilizers or neuroleptics or in the treatment of hypertension. The derivatives have the general formula (I) where R1 is hydrogen or hydroxyl and R2 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, halogen, trifluoromethyl or nitro and n is 0, 1 or 2 if R1 is hydrogen, and is 1 if R1 is hydroxyl.

公开(公告)号：NO152129C

公开(公告)日：1985-08-07

申请号：NO821085

申请日：1982-03-31

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/75