公开(公告)号：DE10319240A1

公开(公告)日：2004-11-18

申请号：DE10319240

申请日：2003-04-28

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  TAEGER TILMAN LUEDECKE ,  PABST GUNTHER ,  LAMALLE PHILIPPE ,  BREUER MICHAEL ,  KROEGER BURKHARD ,  SUBKOWSKI THOMAS

IPC: C14C1/06

Abstract: Removal of keratin from animal skins involves treatment in an aqueous liquor containing, with respect to salted weight, 0.05-5 %, by weight mercaptan(s) (I) or the corresponding alkali(ne earth) metal, ammonium or phosphonium salt(s) and also compound(s) catalyzing hydrolysis of peptide bonds. Removal of keratin from animal skins involves treatment in an aqueous liquor containing, with respect to salted weight, 0.05-5 %, by weight mercaptan(s) of formula (I) or the corresponding alkali(ne earth) metal, ammonium or phosphonium salt(s) and also compound(s) catalyzing hydrolysis of peptide bonds: [Image] R1>H or 1-12 C alkyl, optionally with 1 or more S-H or O-H groups; X1>->4>S-H in at least one case, otherwise H, 1-4 C alkyl, O-H or NHR2>; and R2>H, 1-12 C alkyl or 1-4 C alkyl-C=O. If R1> contains no O-H or S-H, at least one other X1>->4> is S-H, OH or NHR2>. Independent claims are also included for: (1) unhaired hides produced by this process; (2) residual liquor from the process, containing melanine or its degradation products; (3) working up this residual liquor by optionally separating lime, then neutralizing with acid and separating proteins.

公开(公告)号：BR0213772A

公开(公告)日：2004-10-19

申请号：BR0213772

申请日：2002-10-31

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N15/52 ,  C12P13/04 ,  C12N15/77 ,  C12N15/00

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：BR0213770A

公开(公告)日：2004-10-19

申请号：BR0213770

申请日：2002-10-31

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N9/12 ,  C12N15/21 ,  C12N15/31 ,  C12N15/54 ,  C12N9/00 ,  C12N15/77 ,  C12P1/04

Abstract: Isolated nucleic acid (I) that encodes any of 4 amino acid sequences (II) that have, at specific positions, an amino acid (aa) alteration are new. The specification includes (i) a table identifying the function of (II) and the nature/position of the amino acid exchange and (ii) sequences for (I) and (II). Independent claims are also included for the following: (1) Vector that contains at least one (I); (2) Host cell (C) transfected with at least one vector of (1); and (3) Preparing fine chemicals by culturing cells of (C).

公开(公告)号：AU2002368410A1

公开(公告)日：2004-06-23

申请号：AU2002368410

申请日：2002-11-29

Applicant: BASF AG

Inventor： SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  HAEFNER STEFAN ,  KLOPPROGGE CORINNA ,  POMPEJUS MARKUS ,  KROEGER BURKHARD

IPC: C07K14/34 ,  C12N15/31 ,  C12N15/77 ,  C12P13/12 ,  C12R1/13 ,  C12R1/15

公开(公告)号：DE10239073A1

公开(公告)日：2004-03-11

申请号：DE10239073

申请日：2002-08-26

Applicant: BASF AG

Inventor： KROEGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12 ,  C12P11/00 ,  C07C323/58

Abstract: Method for fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A); concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with homoserine O-acetyltransferase (metA) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms; removing water from the fermentation broth and optionally also up to 100% of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：CA2481761A1

公开(公告)日：2003-10-23

申请号：CA2481761

申请日：2003-04-16

Applicant: BASF AG

Inventor： KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N1/15 ,  C12N9/10 ,  C12N15/09 ,  C12P11/00 ,  C12P13/12 ,  C12R1/15 ,  C12N15/63

Abstract: The invention relates to methods for producing sulphurous fine chemicals, in particular L-methionine, by fermentation, using bacteria, in which a nucleotide sequence that codes for a methionine synthase metH gene is expressed.

公开(公告)号：BR0017148A

公开(公告)日：2003-03-11

申请号：BR0017148

申请日：2000-12-22

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  KIM JUN-WON ,  LEE HEUNG-SHICK ,  HWANG BYUNG-JOON

IPC: C12N15/09 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/21 ,  C12N9/90 ,  C12N15/54 ,  C12P20060101 ,  C12P13/08 ,  C12P13/12 ,  C12P21/02 ,  C12R1/13

Abstract: Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins form Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism.

公开(公告)号：CA2453327A1

公开(公告)日：2003-02-20

申请号：CA2453327

申请日：2002-07-10

Applicant: BASF AG

Inventor： KAROS MARVIN ,  KROEGER BURKHARD ,  REVUELTA DOVAL JOSE L ,  ALTHOEFER HENNING

IPC: C07K14/37 ,  C07K14/47 ,  C12N1/15 ,  C12N15/30 ,  C12P25/00 ,  C12Q1/02 ,  C07K16/14 ,  C12N15/52 ,  C12Q1/68 ,  C12N15/80

Abstract: The invention relates to polynucleotides from Ashbya gossypii; oligonucleotides hybridised by the above; expression cassettes and vectors, containing said polynucleotides; micro-organisms transformed with the above; polypeptides coded by said polynucleotides and the use of the polypeptides a nd polynucleotides as targets to improve stress-resistance and, in particular, improve vitamin B2 production in micro-organisms of the species Ashbya.

公开(公告)号：CA2454696A1

公开(公告)日：2003-02-13

申请号：CA2454696

申请日：2002-07-26

Applicant: BASF AG

Inventor： KROEGER BURKHARD ,  REVUELTA DOVAL JOSE L ,  KAROS MARVIN ,  ALTHOEFER HENNING

IPC: C07K14/37 ,  C12N1/15 ,  C12N9/16 ,  C12N15/55 ,  C12N15/11 ,  C12P25/00

Abstract: The invention relates to novel polynucleotides of Ashbya gossypii, oligonucleotides which hybridise therewith, expression cassettes and vectors containing said poynucleotides, micro-organisms transformed thereby, polypeptides coded by said polynucleotides, and the use of the novel polypeptides and polynucleotides as targets for improving signal transductio n mechanisms and especially for improving the production of vitamin B2 in micr o- organisms of the species Ashbya.

公开(公告)号：HU0203191A2

公开(公告)日：2002-12-28

申请号：HU0203191

申请日：2000-06-27

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  KROEGER BURKHARD ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  ZELDER OSKAR

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/31 ,  C12N15/54 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569

Abstract: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. Glutamicum based on genetic engineering of PTS genes in this organism.