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公开(公告)号：KR1020140087724A
公开(公告)日：2014-07-09
申请号：KR1020120158317
申请日：2012-12-31
Applicant: 강원대학교산학협력단
CPC classification number: A61K38/08 , C07K7/06 , Y10S514/886
Abstract: The present invention relates to a peptide composition having an anti-inflammatory effect, wherein the peptide composition is represented by chemical formula 1. In the chemical formula 1, R1, R4, and R5 are hydrogen; R2 and R3 are hydroxyl; K is Lys; G is Gly; T is Thr; E is Glu; and C is Cys. Accordingly, the peptide composition has high in vivo transferring efficiency, does not inhibit immune macrophages, and has an anti-inflammatory effect for inhibiting the activities of PGE2 and AP-1.
Abstract translation: 本发明涉及具有抗炎作用的肽组合物，其中肽组合物由化学式1表示。在化学式1中，R 1，R 4和R 5是氢; R2和R3是羟基; K为Lys; G是Gly; T是Thr; E是Glu; C是Cys。 因此，肽组合物具有高的体内转移效率，不抑制免疫巨噬细胞，并且具有抑制PGE2和AP-1的活性的抗炎作用。
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公开(公告)号：KR1020140087723A
公开(公告)日：2014-07-09
申请号：KR1020120158315
申请日：2012-12-31
Applicant: 강원대학교산학협력단
CPC classification number: A61K38/177 , A61K9/06 , C07K14/4713 , Y10S424/81 , Y10S514/886
Abstract: The present invention relates to a pharmaceutical composition for preventing and treating inflammatory and autoimmune diseases, wherein the pharmaceutical composition includes peptide represented by SEQ ID NO: 1 as an active ingredient. Accordingly, the pharmaceutical composition has high in vivo transferring efficiency, does not inhibit immune macrophages, and inhibits the activities of PGE2, AP-1, and TNF-α.
Abstract translation: 本发明涉及用于预防和治疗炎性和自身免疫性疾病的药物组合物，其中该药物组合物包含SEQ ID NO：1所示的肽作为活性成分。 因此，药物组合物具有高的体内转移效率，不抑制免疫巨噬细胞，并且抑制PGE2，AP-1和TNF-α的活性。
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公开(公告)号：KR101228381B1
公开(公告)日：2013-01-31
申请号：KR1020110031169
申请日：2011-04-05
Applicant: 강원대학교산학협력단
IPC: C07C45/61 , C07C49/537 , C07C69/753 , C07D307/80
Abstract: 본 발명은 철 촉매를 이용하여 α-알키닐 β-케토에스터 화합물의 분자내 고리화 반응을 통하여 온화한 조건하에서 보다 간단한 방법을 통해 높은 수율로 5각고리 화합물을 합성하는 제조방법을 제공한다.
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公开(公告)号：KR101210428B1
公开(公告)日：2012-12-10
申请号：KR1020100104367
申请日：2010-10-26
Applicant: 강원대학교산학협력단
Abstract: 본발명은하기화학식 1로표시되는엔올포스페이트유도체및 이의제조방법에관한것이다. 보다상세하게는, 서로다른금 촉매계를이용하여알카인유도체를포스페이트유도체와의첨가반응을통하여하기화학식 A로표시되는카이네틱(kinetic) 엔올포스페이트유도체와하기화학식 B로표시되는써모다이나믹(thermodynamic) 엔올포스페이트유도체를각각선택적으로제조하는방법에관한것이다. [화학식 1][화학식 A][화학식 B]상기화학식 1, 화학식 A 및화학식 B에서 R, R, R및 R는각각발명의상세한설명에서정의한바와같다.
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Patent Agency Ranking
公开(公告)号：KR101452337B1
公开(公告)日：2014-10-22
申请号：KR1020140065859
申请日：2014-05-30
Applicant: 강원대학교산학협력단
IPC: C07F9/6574 , C07F9/6581
CPC classification number: C07F9/65846 , C07F9/657163 , C07F9/657172 , C07F9/657181
Abstract: The present invention relates to a novel phosphinine oxide derivative and a preparing method thereof. More specifically, the phosphinine oxide derivative of the present invention comprises oxaphosphinine oxide and azaphosphinine oxide derivatives. The phosphinine oxide derivative according to the present invention has pharmacological activity and bioactivity, and can be used in novel drug development and synthesis of various pharmaceuticals as well as used as a basic structure of natural materials. In addition, the method for preparing the phosphinine oxide derivative according to the present invention has strong points of preparing various phosphinine oxide derivatives having high yield through a simple synthesizing process by conducting intermolecular cyclicizing reaction of a phosphinine derivative and an alkyne derivative with a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidizing agent.
Abstract translation: 本发明涉及一种新的次膦酰氧化物衍生物及其制备方法。 更具体地，本发明的次膦氧化物衍生物包含氧化磷腈氧化物和氮杂磷酸氧化物衍生物。 本发明的次膦氧化物衍生物具有药理活性和生物活性，可用于各种药物的新药开发和合成，也可用作天然物质的基本结构。 此外，根据本发明的制备氧化膦氧化物衍生物的方法通过简单的合成方法制备具有高产率的各种次膦酸氧化物衍生物的优点是通过将次膦酸衍生物和炔衍生物与铑进行分子间环化反应（ Rh）催化剂或钌（Ru）催化剂和氧化剂。
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公开(公告)号：KR101254538B1
公开(公告)日：2013-04-19
申请号：KR1020110027843
申请日：2011-03-28
Applicant: 강원대학교산학협력단
IPC: C07C67/30 , C07C69/606 , C07C69/76 , B01J31/24
Abstract: 본 발명은 하기 화학식 1로 표시되는 α, β-이노에이트(ynoate) 유도체의 제조방법에 관한 것이다. 보다 상세하게는, 팔라듐 촉매 하에서, 하기 화학식 2로 표시되는 아릴 할라이드 유도체와 하기 화학식 3으로 표시되는 유기인듐 시약의 교차 짝지움 반응을 통하여 α, β-이노에이트 유도체를 제조하는 방법에 관한 것이다.
[화학식 1]
[화학식 2]
[화학식 3]
[상기 화학식 1, 2 및 3에서 R
1 , R
2 , Ar 및 X은 각각 발명의 상세한 설명에서 정의한 바와 같다.]-
公开(公告)号：KR1020130019472A
公开(公告)日：2013-02-27
申请号：KR1020110081434
申请日：2011-08-17
Applicant: 강원대학교산학협력단
CPC classification number: A61K38/16 , A61K9/06 , A61K38/38 , Y10S514/885 , Y10S514/886
Abstract: PURPOSE: A peptide nanofiber for preventing and treating inflammatory and autoimmune diseases is provided to suppress expression and generation of PGE2(prostaglandin), AP-1, and TNF-alpha and to prevent and treat the diseases. CONSTITUTION: A peptide nanofiber for preventing and treating inflammatory and autoimmune diseases is a self-assembly type. The peptide nanofiber includes lysozyme, a trypsin inhibitor, BSA(bovine serum albumin), and IgG protein. The peptide nanofiber contains Acetyl-(Arg-Ala-Asp-Ala)4-CONH2[Ac-(RADA)4-CONH2] peptide hydrogel. The peptide nanofiber suppresses PGE2, AP-1, and TNF-alpha activation.
Abstract translation: 目的：提供用于预防和治疗炎症和自身免疫疾病的肽纳米纤维，以抑制PGE2（前列腺素），AP-1和TNF-α的表达和产生并预防和治疗疾病。 构成：用于预防和治疗炎性和自身免疫性疾病的肽纳米纤维是一种自组装型。 肽纳米纤维包括溶菌酶，胰蛋白酶抑制剂，BSA（牛血清白蛋白）和IgG蛋白。 肽纳米纤维含有乙酰基 - （Arg-Ala-Asp-Ala）4-CONH 2 [Ac-（RADA）4-CONH 2]肽水凝胶。 肽纳米纤维抑制PGE2，AP-1和TNF-α激活。
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公开(公告)号：KR1020120109929A
公开(公告)日：2012-10-09
申请号：KR1020110027843
申请日：2011-03-28
Applicant: 강원대학교산학협력단
IPC: C07C67/30 , C07C69/606 , C07C69/76 , B01J31/24
Abstract: PURPOSE: A manufacturing method of A, B-ynoate derivative is provided to manufacture A, B-ynoate derivatives with high yield through a cross coupling reaction of aryl halide derivative and organic indium under the presence of a palladium catalyst. CONSTITUTION: A manufacturing method of A, B-ynoate derivative comprises a step of preparing A, B-ynoate in chemical formula 1: R^2O2C≡R^1 by a cross coupling reaction of an aryl halide derivative in chemical formula 2: R^1-Ar-X and an organic indium specimen in chemical formula 3: [R^2O2C≡]4-InLi under the presence of a palladium catalyst and phosphine ligand. In the chemical formulas R^1 is hydrogen, (C1-C7)alkyl, (C1-C7) alkoxy, halogen, (C1-C7) alkoxycarbonyl, (C1-C7)alkylcarbonyl or *≡CO2R^3, R^2 and R^3 is respectively (C1-C7)alkyl, Ar is (C6-C20) arylene or (C3-C20)heteroarylene, and X is halogen.
Abstract translation: 目的：提供A，B-ynoate衍生物的制备方法，通过芳基卤衍生物和有机铟的交叉偶联反应，在钯催化剂存在下，以高产率制备A，B-ynate衍生物。 构成：A，B-ynoate衍生物的制造方法包括通过化学式2中的芳基卤衍生物的交叉偶联反应制备化学式1中的A，B-ynate的步骤：R ^2O2C≡R^ 1：R 1-Ar-X和化学式3中的有机铟试样：[R 2 O 2C≡] 4-InLi，在钯催化剂和膦配体存在下。 在化学式中，R 1是氢，（C 1 -C 7）烷基，（C 1 -C 7）烷氧基，卤素，（C 1 -C 7）烷氧基羰基，（C 1 -C 7）烷基羰基或*≡CO2 R 3，R 2和 R 3分别为（C 1 -C 7）烷基，Ar为（C 6 -C 20）亚芳基或（C 3 -C 20）亚杂芳基，X为卤素。
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公开(公告)号：KR100953177B1
公开(公告)日：2010-04-15
申请号：KR1020090132891
申请日：2009-12-29
Applicant: 강원대학교산학협력단
IPC: A61K31/167 , A61K31/166 , A61P29/00 , A23L1/30
Abstract: PURPOSE: A resveratrol derivative compound having activities of anti-inflammation and immune modulation is provided to reduce NO generation and suppress anti-inflammation with low cytotoxicity. CONSTITUTION: A composition for preventing or treating inflammatory diseases contains a compound of chemical formula 1 as an active ingredient. In chemical formula 1, OH is substituted with ortho, meta or para of phenyl ring; either m or n is not 0 and independently 0, 1 or 2. A functional health food for preventing or treating inflammatory diseases contains resveratrol derivative of chemical formula 1 and sitologically acceptable food additive.
Abstract translation: 目的：提供具有抗炎和免疫调节活性的白藜芦醇衍生物，以减少NO产生，抑制细胞毒性低的抗炎。 构成：用于预防或治疗炎性疾病的组合物含有化学式1化合物作为活性成分。 在化学式1中，OH被苯环的邻位，间位或对位取代; m或n不为0且独立地为0,1或2.用于预防或治疗炎性疾病的功能性保健食品包含化学式1的白藜芦醇衍生物和可以使用的可食用食品添加剂。
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