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    이소인돌리논 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물
    18.
    发明公开
    이소인돌리논 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물 有权
    ISOINDOLINONE衍生物，其制备方法和包含其的药物组合物

    公开(公告)号：KR1020100123459A

    公开(公告)日：2010-11-24

    申请号：KR1020090042691

    申请日：2009-05-15

    Applicant: 한국화학연구원

    Inventor： 허정녕 ,  김범태 ,  이혁 ,  장성연 ,  이장희 ,  김성환 ,  류현모

    IPC: C07D209/46 ,  C07D209/44 ,  A61K31/4035 ,  A61P19/10

    Abstract: PURPOSE: An isoindolinone derivative and pharmaceutical composition containing the same are provided to enhance expression of alkaline phosphatase. CONSTITUTION: An insoindolinone derivative is denoted by chemical formula 1. A method for preparing the isoindolinone derivative comprises a step of amide-coupling phenylene diamine with a compound of chemical formula 8 to obtain an isoindolinone of chemical formula 2. In case of that one or more substituent R1-R4 in chemical formula 8 are halogen, the method further comprises a step of Suzuki-coupling boronic acid compound of chemical formula 17(RB(OH)_2) under the presence of palladium catalyst. A pharmaceutical composition for preventing or treating bone diseases contains the isoindolinone derivative of chemical formula 1 or pharmaceutically acceptable salt as an active ingredient.

    Abstract translation: 目的：提供异吲哚啉酮衍生物和含有它们的药物组合物，以增强碱性磷酸酶的表达。 构成：异吲哚啉酮衍生物由化学式1表示。制备异吲哚啉酮衍生物的方法包括将苯二胺与化学式8的化合物酰胺偶联以获得化学式2的异吲哚满酮的步骤。如果是那种或 化学式8中更多的取代基R 1 -R 4是卤素，该方法还包括在钯催化剂存在下的化学式17（RB（OH）2）的Suzuki-偶联硼酸化合物的步骤。 用于预防或治疗骨疾病的药物组合物含有化学式1的异吲哚啉酮衍生物或其药学上可接受的盐作为活性成分。

    벤조싸이아졸 유도체, 이의 제조 방법 및 이를 포함하는살균제 조성물
    19.
    发明授权
    벤조싸이아졸 유도체, 이의 제조 방법 및 이를 포함하는살균제 조성물 失效
    이이졸

    公开(公告)号：KR100929358B1

    公开(公告)日：2009-12-08

    申请号：KR1020080006333

    申请日：2008-01-21

    Applicant: 한국화학연구원 ,  주식회사경농

    Inventor： 허정녕 ,  김범태 ,  이혁 ,  장성연 ,  박노균 ,  장경수

    IPC: C07D277/82 ,  A01N43/78

    Abstract: A benzothiazole derivatives is provided to prevent the generation of drug resistance bacteria and improve the sterilization effect to plant late blight. A benzothiazole derivative is denoted by the chemical formula 1. In the chemical formula 1, X is H or C1-4 alkoxyl. The structure of Y is selected among structure formulas a, b, c, d, e, and f. The left side of Y is connected to N, the right side is connected to Z. R2 is H or C1-4 alkyl. Z is phenyl; phenyl which is substituted with one selected among halogen atom, cyano, methyl, nitro, phenyl, phenoxy, trifluoromethyl and hydroxyl, and isoxazole which is substituted with phenyl, chlorophenyl, or dichlorophenyl.

    Abstract translation: 提供苯并噻唑衍生物以防止产生耐药性细菌并提高杀死植物晚疫病的效果。 苯并噻唑衍生物由化学式1表示。在化学式1中，X是H或C1-4烷氧基。 Y的结构选自结构式a，b，c，d，e和f。 Y的左侧连接到N，右侧连接到Z.R2是H或C1-4烷基。 Z是苯基; 被选自卤原子，氰基，甲基，硝基，苯基，苯氧基，三氟甲基和羟基中的一个取代的苯基和被苯基，氯苯基或二氯苯基取代的异恶唑。

    2-이미노벤조이미다졸 유도체를 포함하는 살균제 조성물
    20.
    发明公开
    2-이미노벤조이미다졸 유도체를 포함하는 살균제 조성물 失效
    含有二氨基苯并咪唑衍生物的抗菌组合物

    公开(公告)号：KR1020090084502A

    公开(公告)日：2009-08-05

    申请号：KR1020080010723

    申请日：2008-02-01

    Applicant: 한국화학연구원 ,  주식회사경농

    Inventor： 김범태 ,  허정녕 ,  이혁 ,  장성연 ,  박노균 ,  최경자

    IPC: A01N43/50

    CPC classification number: A01N43/52 ,  A01N43/80 ,  A01N43/82 ,  C07D235/04 ,  C07D403/10 ,  C07D403/12 ,  C07D413/06

    Abstract: A germicide composition is provided to suppress the generation of drug-resistance bacteria using 2-iminobenzoimidazole derivative. A germicide composition comprises a 2-iminobenzoimidazole derivative of the chemical formula 1 as an active ingredient. In the chemical formula 1, R1 is C1-7 alkyl, C2-7 alkenyl, -CH2CH2NR^0(R^0 is diethyl or -CH2CH2OCH2CH2-) and benzyl which is not substituted or is substituted with one or more halogen or C1-3 alkyl. R2 is a phenyl which is not substituted or is substituted with one or more halogen atom, aryl or aryloxy, naphtyl, phenoxy methyl which is not substituted or is substituted with one or more halogen atom, C1-3 alkyl or C1-3 alkoxy, phenyl isoxazole which is not substituted or substituted with one or more halogen atom or 4-methyl-3-phenyl-1,2,4-oxadiazole-5(4H)-one.

    Abstract translation: 提供杀菌剂组合物以抑制使用2-亚氨基苯并咪唑衍生物产生耐药菌。 杀菌剂组合物包含化学式1的2-亚氨基苯并咪唑衍生物作为活性成分。 在化学式1中，R 1为C 1-7烷基，C 2-7烯基，-CH 2 CH 2 NR 2 O（R 10为二乙基或-CH 2 CH 2 OCH 2 CH 2 - ）和未被取代或被一个或多个卤素或C1- 3烷基。 R2是未被取代或被一个或多个卤素原子取代的苯基，未被取代或被一个或多个卤素原子取代的苯基甲基，芳基或芳氧基，苯基甲基，C 1-3烷基或C 1-3烷氧基， 未被一个或多个卤素原子取代或取代的苯基异恶唑或4-甲基-3-苯基-1,2,4-恶二唑-5（4H） - 酮。

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