公开(公告)号：KR1020090027913A

公开(公告)日：2009-03-18

申请号：KR1020070093102

申请日：2007-09-13

Applicant: 재단법인서울대학교산학협력재단

Inventor： 윤제용 ,  문성민 ,  이윤우 ,  정진성

IPC: A61L2/07 ,  A61L2/22

CPC classification number: A61L2/07 ,  A61L2/22 ,  A61L2202/12

Abstract: A method for inactivating biofilm is provided, which inactivates the biofilm in an improved disinfecting power using the supercritical fluid in a short time. A method for inactivating biofilm using the supercritical fluid comprises: a step for positioning an object in which the biofilm is formed in the surface at the high pressure container; and a step for inactivating biofilm by bringing the biofilm into contact with the supercritical fluid. The biofilm using the supercritical fluid is exposed to the supercritical fluid in the state that it is not dipped in the aqueous medium and the moisture is adhered. The supercritical fluid comprises the supercritical carbon dioxide, and the supercritical nitrous oxide or their mixture fluid.

Abstract translation: 提供灭活生物膜的方法，其在短时间内使用超临界流体在改进的消毒功能中使生物膜失活。 使用超临界流体灭活生物膜的方法包括：用于定位在高压容器的表面中形成生物膜的物体的步骤; 以及通过使生物膜与超临界流体接触来灭活生物膜的步骤。 使用超临界流体的生物膜在不浸渍在水性介质中并且水分被粘附的状态下暴露于超临界流体。 超临界流体包括超临界二氧化碳和超临界一氧化二氮或其混合流体。

公开(公告)号：KR1020080073130A

公开(公告)日：2008-08-08

申请号：KR1020070011753

申请日：2007-02-05

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이석근 ,  김연숙 ,  이윤우 ,  지제근 ,  박상철 ,  이대성 ,  이대관

IPC: C12Q1/68

CPC classification number: G06F19/26 ,  C12Q1/6811 ,  C12Q1/6869 ,  C12Q2563/116

Abstract: A method for visualizing nucleotide and analyzing polarity thereof is provided to be applied to select a DNA sequence for a PCR primer or a DNA probe, search a restriction site from DNA, differentiate a promoter region from exon and intron from a genomic DNA(gDNA), and search for genetic mutation and be effectively used to decipher a DNA code cipher through an electrostatic structure of the DNA code. A method for visualizing nucleotide and analyzing polarity thereof comprises the steps of: (a) visualizing nucleotide bases of A, G, T or U, and C in a sequence to mark A as an upper empty semicircle, G as an upper full semicircle, T or U as a lower empty semicircle, and C as a lower full semicircle based on the horizon; (b) putting together a continuous arrangement of pyrimidine(s)-purine(s) from an arrangement of a sequence proceeding from 5' end to 3' end of the marked nucleotide and dividing it into a nucleotide segment; and (c) calculating a nucleotide total base pair binding energy(total DHE/DS), a nucleotide segment average base pair binding energy(average DHE/DS), and a nucleotide segment polarity base pair binding energy(polarity DHE/DS) regarding the divided nucleotide segments using a migration pattern of electrons inside of the nucleotide.

Abstract translation: 为了选择PCR引物或DNA探针的DNA序列，提供了核苷酸可视化和极性分析的方法，从DNA的限制位点搜索，从基因组DNA（gDNA）区分启动子区域与外显子和内含子， 并寻找遗传突变，并通过DNA代码的静电结构有效地用于破译DNA密码。 可视化核苷酸和分析其极性的方法包括以下步骤：（a）将A，G，T或U和C的核苷酸碱基以序列形式显现，将A标记为上空半圆，G作为上半圆， T或U作为下半空半圆，C为基于水平线的较低全半圆; （b）从标记核苷酸的5'末端到3'末端的序列排列组合一个或多个嘧啶连续排列，并将其分成核苷酸区段; 和（c）计算核苷酸总碱基对结合能（总DHE / DS），核苷酸区段平均碱基对结合能（平均DHE / DS）和核苷酸区段极性碱基对结合能（极性DHE / DS） 分割的核苷酸片段使用核苷酸内部的电子迁移模式。

公开(公告)号：KR100840132B1

公开(公告)日：2008-06-23

申请号：KR1020070037619

申请日：2007-04-17

Applicant: 재단법인서울대학교산학협력재단

Inventor： 주준호 ,  신내철 ,  김화용 ,  이윤우

IPC: C07D501/59 ,  B01D11/00

Abstract: A method for drying cefpodoxime proxetil is provided to obtain the cefpodoxime proxetil with almost no remaining solvent with reduced cost and drying time by performing a drying process using a saturated liquid CO2, which is relatively cheap, harmless to human body and non-reactive with a product. A method for drying cefpodoxime proxetil comprises a step of removing at least one remaining organic solvent selected from the group consisting of diisopropylether, ethyl acetate and dichloromethane by circulating saturated liquid carbon dioxide using a reboiler and a condenser without using a power unit such as a pump during a process of preparing the cefpodoxime proxetil.

Abstract translation: 提供了一种干燥头孢泊肟原料的方法，通过使用相对便宜的对人体无害的并且与人体无反应的饱和液体CO 2进行干燥处理，几乎没有残留的溶剂，几乎没有残留的溶剂，从而获得头孢泊肟几乎没有残留的溶剂 产品。 用于干燥头孢泊肟原料的方法包括通过使用再沸器和冷凝器循环饱和液体二氧化碳除去至少一种选自二异丙醚，乙酸乙酯和二氯甲烷的剩余有机溶剂的步骤，而不使用动力单元如泵 在制备头孢泊肟原料的过程中。

公开(公告)号：KR100994217B1

公开(公告)日：2010-11-12

申请号：KR1020080094515

申请日：2008-09-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  강병희 ,  신영호 ,  김화용

IPC: C08F6/06 ,  C08F6/10 ,  C08F220/00 ,  C08F220/06

CPC classification number: Y02P20/544

Abstract: 가압 액체, 초임계유체 및 그들의 혼합물을 사용하여 아크릴산과 수분이 제거된 초 흡수성 중합체의 제조방법이 개시되어 있다. 이를 수행하기 위해서는 중합 반응으로 형성된 초 흡수성 중합체에 가압 액체, 초임계 유체 또는 이들의 혼합물을 제공한다. 이후, 가압 액체, 초임계 유체 또는 이들의 혼합물을 이용한 추출 공정을 수행하여 중합반응으로 형성된 초 흡수 중합체 내에 잔류하는 아크릴산과 수분을 추출한다. 이로 인해, 상기 추출공정으로 형성된 초 흡수성 중합체는 아크릴산 잔류량이 20 내지 500ppm인 초 흡수성 중합체로 형성된다.
초 흡수성 중합체, 잔류 용매, 초임계, 이산화탄소

公开(公告)号：KR1020100000923A

公开(公告)日：2010-01-06

申请号：KR1020080060606

申请日：2008-06-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 윤제용 ,  문성민 ,  이윤우

IPC: A23L3/3526 ,  A23L3/34 ,  A23L3/3463

CPC classification number: A23L3/3526 ,  A23L2/38 ,  A23L2/52 ,  A23V2002/00 ,  A23V2250/134

Abstract: PURPOSE: A method for sterilizing beverages using nitrous oxide is provided to control the pH change of beverages and to sterilize beverages with sterilizing power in a short time using liquid or supercritical nitrous oxide. CONSTITUTION: A method for sterilizing beverages using nitrous oxide comprises the steps of: positioning liquid beverages inside a high pressure container; sterilizing microbe existing in beverages without the pH change of beverages by contacting with liquid or supercritical nitrous oxide in the pressure of 40 - 500bar; and stirring two phases while contacting with liquid or supercritical nitrous oxide.

Abstract translation: 目的：提供一种使用一氧化二氮灭菌饮料的方法，以控制饮料的pH变化，并在短时间内使用液体或超临界一氧化二氮灭菌消毒灭菌能力的饮料。 构成：使用一氧化二氮灭菌饮料的方法包括以下步骤：将液体饮料定位在高压容器内; 通过与40-500bar的压力下的液体或超临界一氧化二氮接触，在饮料中不存在饮料的pH变化而存在于饮料中的消毒微生物; 并在与液体或超临界一氧化二氮接触的同时搅拌两相。

公开(公告)号：KR100881407B1

公开(公告)日：2009-02-05

申请号：KR1020070091886

申请日：2007-09-11

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  주준호 ,  리광화 ,  노경호

IPC: C07C233/07 ,  C07C233/01

CPC classification number: Y02P20/544

Abstract: Acetaminophen fine particles are provided to control the crystal polymorphism of drug by diversifying parameters in manufacturing the particles and to be usable for an immediate release analgesic composition due to improved elution rate. A method for manufacturing acetaminophen fine particles comprises (a) a step for preparing the solution by dissolving acetaminophen in ethylacetate or tetrahydrofurane; (b) a step for preparing the acetaminophen fine particles by mixing carbon dioxide of 0-45 °C and 35-200 pressure(atm) and the solution obtained from the (a) step in a precipitator; (c) a step for removing an organic solvent remaining in particles by using the supercritical carbon dioxide of 0-45 °C and 35-200 pressure(atm); and (d) a step for collecting the fine particles generated through the pressure reduction of the inside of the precipitator.

Abstract translation: 提供对乙酰氨基酚微粒以通过使制造颗粒的参数多样化来控制药物的晶体多晶性，并且由于洗脱速率的提高，可用于立即释放止痛组合物。 制备对乙酰氨基酚微粒的方法包括（a）通过将对乙酰氨基酚溶解在乙酸乙酯或四氢呋喃中制备溶液的步骤; （b）通过混合0-45℃和35-200压力（atm）的二氧化碳和从（a）步骤获得的溶液在沉淀器中制备对乙酰氨基酚微粒的步骤; （c）通过使用0-45℃和35-200压力（atm）的超临界二氧化碳除去残留在颗粒中的有机溶剂的步骤; 和（d）用于收集通过除尘器内部的减压产生的微粒子的步骤。

公开(公告)号：KR1020080096298A

公开(公告)日：2008-10-30

申请号：KR1020070041590

申请日：2007-04-27

Applicant: 재단법인서울대학교산학협력재단 ,  주식회사 유맥스

Inventor： 송은석 ,  최성환 ,  이윤우 ,  주영운 ,  신언무

IPC: C11B3/00

Abstract: A supercritical fluid extraction method is provided to prevent the crushing of rice through maintaining moisture content in brown rice and to selectively extract only a fat ingredient, by adding water as an assistant solvent to a supercritical carbon dioxide used as an extraction solvent in a process of manufacturing functional brown rice removed with a fat ingredient of the surface of brown rice. A supercritical fluid extraction method without the crushing of rice extracts fat ingredient from brown rice by using supercritical carbon dioxide as a main solvent and water as an assistant solvent. The supercritical state of carbon dioxide is characterized in that the temperature is 31-60 deg.C, the pressure is 100-350 bar, the density of supercritical carbon dioxide is 0.6-1.0 g / cm^3, and the weight fraction of carbon dioxide to added water is 0.001 - 0.005.

Abstract translation: 提供了一种超临界流体萃取方法，通过保持糙米中的水分含量来防止米饭的破碎，并通过将水作为辅助溶剂加入到用作萃取溶剂的超临界二氧化碳中，以选择性地提取脂肪成分。 用糙米表面的脂肪成分除去制造功能性糙米。 采用超临界二氧化碳为主要溶剂，水为辅助溶剂，从米糠中提取脂肪成分的超临界流体萃取方法。 二氧化碳的超临界状态的特点是温度为31-60摄氏度，压力为100-350巴，超临界二氧化碳的密度为0.6-1.0克/立方厘米，碳的重量分数 二氧化碳与水的添加量为0.001〜0.005。