公开(公告)号：KR1020120029985A

公开(公告)日：2012-03-27

申请号：KR1020110046983

申请日：2011-05-18

Applicant: 한국식품연구원

Inventor： 김인호 ,  한대석 ,  이창호 ,  조승목 ,  고성호 ,  심인섭

IPC: A23L2/38 ,  A23L33/00 ,  A61K31/70 ,  A61P3/04

CPC classification number: A23L33/10 ,  A23L33/30 ,  A23V2200/30 ,  A23V2200/332

Abstract: PURPOSE: A functional beverage composition having an appetite suppression function is provided to enable users to drink the beverage for a long time without side effects. CONSTITUTION: A functional beverage composition having an appetite suppression function is a component having the inhibiting activity of ghrelin promoting the appetite of a user. The composition contains less than 15 parts by weight of compounds selected from 3-hydroxyflavone, rutin, naringin, or hesperidin. The functional beverage composition additionally contains natural carbohydrate, additives, and a sweetener. The additives are selected from vitamins, minerals, a coloring agent, pectic acid or its salt, alginic acid or its salt, organic acid, a protective colloid thickening agent, a pH-adjusting agent, or other ingredients.

Abstract translation: 目的：提供具有食欲抑制功能的功能饮料组合物，以使用户能够长时间饮用饮料而没有副作用。 构成：具有食欲抑制功能的功能饮料组合物是具有促进使用者胃口的生长素释放肽的抑制活性的成分。 该组合物含有少于15重量份的选自3-羟基黄酮，芦丁，柚皮苷或橙皮苷的化合物。 功能性饮料组合物另外含有天然碳水化合物，添加剂和甜味剂。 添加剂选自维生素，矿物质，着色剂，果胶酸或其盐，藻酸或其盐，有机酸，保护胶体增稠剂，pH调节剂或其它成分。

公开(公告)号：KR1020090057835A

公开(公告)日：2009-06-08

申请号：KR1020070124593

申请日：2007-12-03

Applicant: 한국식품연구원

Inventor： 고성호 ,  박태정 ,  조용진

IPC: C07K19/00

Abstract: A recombinant fusion protein is provided to simply fix all kinds of antibodies and give proper orientation to fixed antibody. A recombinant fusion protein is encoded by sequence number 10 or 11. A polynucleotide has a sequence of sequence number 10 or 11. A biosensor comprises the recombinant fusion protein and gold-containing solid phase. The gold-containing solid phase is selected from a gold colloidal particle, nano-gold particle, and substrate containing gold-coating particle. A method of immuno detection of target material comprises: a step of combining an antibody with the recombinant fusion protein of the biosensor; and a step of treating the antibody-specific antigen to detect the specific binding of antigen-antobody.

Abstract translation: 提供重组融合蛋白以简单地固定所有种类的抗体并给予固定抗体正确取向。 重组融合蛋白由序列号10或11编码。多核苷酸具有序列号10或11的序列。生物传感器包含重组融合蛋白和含金固相。 含金固相选自金胶体颗粒，纳米金颗粒和含有金涂层颗粒的底物。 靶物质的免疫检测方法包括：将抗体与生物传感器的重组融合蛋白结合的工序; 以及治疗抗体特异性抗原以检测抗原 - 附着物的特异性结合的步骤。

公开(公告)号：KR1020120060027A

公开(公告)日：2012-06-11

申请号：KR1020100121579

申请日：2010-12-01

Applicant: 한국식품연구원

Inventor： 고성호 ,  김아람 ,  권대영 ,  김인호 ,  김명선 ,  김영찬 ,  김철진

IPC: G01N33/53 ,  G01N33/543 ,  G01N33/569

CPC classification number: Y02A50/52 ,  Y02A50/59

Abstract: PURPOSE: A sandwich immunoassay biochip and an immunoassay using the same are provided to accurately and quickly detect pathogens. CONSTITUTION: A sandwich immunoassay biochip contains: a first protein which binds to Fc domain conjugated to a functional group of a surface-modified solid-support; a capture antibody conjugated to the first protein; a second protein which binds to Fc site of an antibody conjugated to a functional group of surface-modified polystyrene beads; and a detection antibody conjugated to the second protein. The functional groups of the solid-support and polystyrene beads are an amine group and a carboxyl group, respectively. The solid-support is a glass, polysterene, or metal. A sandwich immunoassay using the biochip comprises: a step of contacting a sample containing an antigen to the biochip; a step of specifically binding the antibody to the capture antibody; a step of binding the detection antibody to an epitope which is not conjugated with the capture antibody; and a step of detecting specific antigen-antibody binding.

Abstract translation: 目的：提供三明治免疫测定生物芯片和使用其的免疫测定以准确和快速地检测病原体。 构成：夹心免疫测定生物芯片包含：与结合表面改性固体支持物官能团的Fc结构域结合的第一种蛋白质; 与第一蛋白质缀合的捕获抗体; 结合与表面改性的聚苯乙烯珠的官能团缀合的抗体的Fc位点的第二种蛋白质; 和与第二蛋白质缀合的检测抗体。 固体支持体和聚苯乙烯珠粒的官能团分别是胺基和羧基。 固体支持物是玻璃，聚苯乙烯或金属。 使用生物芯片的夹心免疫测定法包括：使含有抗原的样品与生物芯片接触的步骤; 将抗体特异性结合到捕获抗体的步骤; 将检测抗体与未与捕获抗体结合的表位结合的步骤; 以及检测特异性抗原 - 抗体结合的步骤。

公开(公告)号：KR1020120046967A

公开(公告)日：2012-05-11

申请号：KR1020100108541

申请日：2010-11-03

Applicant: 한국식품연구원

Inventor： 김인호 ,  한대석 ,  이창호 ,  조승목 ,  고성호 ,  심인섭

IPC: A23L33/20 ,  A61P3/04

CPC classification number: A23L33/20 ,  A23V2002/00 ,  A23V2200/332

Abstract: PURPOSE: An appetite suppressing food component composition containing a specific compound as an active ingredient is provided to prevent the appearance of side effects after eating for a long time. CONSTITUTION: An appetite suppressing food component composition contains more than one compound selected from the group consisting of ascorbic acid, beta-D-glucan, hesperetin, melatonin, ginsenoside-Rb1, and ginsenoside-Rg1. An effect obtained from the appetite suppressing food component is a ghrelin activity suppressing effect. The composition is capable of suppressing the activity of ghrelin at the temperature of 60-100 deg C and in the pH of 2-10.

Abstract translation: 目的：提供含有特定化合物作为活性成分的食欲抑制食品成分组合物，以防止长期饮食后出现副作用。 构成：食欲抑制食品成分组合物含有选自抗坏血酸，β-D-葡聚糖，橙皮素，褪黑激素，人参皂甙Rb1和人参皂苷-Rg1的多种化合物。 从食欲抑制食品成分获得的效果是抑制Ghrelin活性的作用。 该组合物能够抑制生长素释放肽在60-100℃的温度和2-10的pH下的活性。

公开(公告)号：KR1020120017912A

公开(公告)日：2012-02-29

申请号：KR1020100080863

申请日：2010-08-20

Applicant: 한국식품연구원

Inventor： 윤석후 ,  권대영 ,  김현진 ,  박재호 ,  양혜정 ,  김명선 ,  황진택 ,  허행전 ,  성미정 ,  고성호 ,  김진희 ,  노시원

IPC: G01N33/50 ,  G01N33/68 ,  G01N33/66 ,  G01N33/92

Abstract: PURPOSE: A method for detecting a marker contained in a biological sample is provided to diagnose and treat obesity or obesity-associated diseases. CONSTITUTION: A method for detecting a marker contained in a biological sample for diagnosing obesity comprises a step of detecting the concentration of arginine, tyrosine, pipecolic acid, benzoic acid, pantothenic acid, uric acid, phenyl acetamide, serotonin, L-carnitine, decanoyl carnitine, myristoyl carnitine, hexadekenoyl carnitine, linoleyl carnitien, vacenyl carnitine, stearoyl carnitine, lysoPC(C14:0), lysoPC(C15:0), lysoPC(C16:0), lysoPC(C16:1), lysoPC(C17:0), lysoPC(C17:1), lysoPC(C18:0), lysoPC(C18:1), lysoPC(C18:2), lysoPC(C18:3), lysoPC(C19:0), lysoPC(C20:1), lysoPC(C20:4), lysoPC(C20:5), lysoPE(C18:2), lysoPE(C20:4) or PCs marker in blood or glucose, glycerol, tyrosine, valine, 7-ketodeoxy cholic acid, and betain, L-carnitine, plamitic acid, linoleic acid, oleic acid, stearic acid, lysoPC(C14:0), lysoPC(C16:0), lysoPC(C16:1), lysoPC(C18:0), lysoPC(C18:3), lysoPC(C20:4), lysoPC(C22:6), or PCs in liver tissue.

Abstract translation: 目的：提供一种用于检测生物样品中包含的标记物的方法，用于诊断和治疗肥胖或肥胖相关疾病。 构成：用于检测用于诊断肥胖的生物样品中所含的标记物的方法包括检测精氨酸，酪氨酸，哌可酸，苯甲酸，泛酸，尿酸，苯乙酰胺，5-羟色胺，L-肉毒碱，癸酰基 肉毒碱，肉豆蔻肉碱，六酰基肉碱，亚油酰肉碱，肉桂碱肉碱，硬脂酰肉碱，溶血糖（C14：0），溶血卵磷脂（C15：0），溶血卵磷脂（C16：0），溶血卵磷脂（C16： ），lysoPC（C17：1），lysoPC（C18：0），lysoPC（C18：1），lysoPC（C18：1），lysoPC（C18：2），lysoPC（C18：3） ，血液或葡萄糖，甘油，酪氨酸，缬氨酸，7-酮基脱氧胆酸和甜菜碱中的溶血卵磷脂（C20：4），溶血卵磷脂（C20：5），溶血蛋白（C18：2），溶血蛋白（C20：4） ，L-carnitine，plamitic acid，亚油酸，油酸，硬脂酸，lysoPC（C14：0），lysoPC（C16：0），lysoPC（C16：1），lysoPC（C18：0），lysoPC（C18：3 ），溶血卵磷脂（C20：4），溶血卵磷脂（C22：6）或肝组织中的PC。

公开(公告)号：KR100873439B1

公开(公告)日：2008-12-11

申请号：KR1020070028287

申请日：2007-03-22

Applicant: 한국식품연구원

Inventor： 조용진 ,  김철진 ,  김종태 ,  전향숙 ,  최성욱 ,  고성호 ,  김재호 ,  김효섭

IPC: G01N33/00 ,  G01N33/48 ,  B82Y15/00

Abstract: 본 발명은 표면 플라즈몬 공명 기술을 이용한 센서칩용 나노금속 콜로이드 기판에 관한 것으로서, 본 발명에서는 금속층이 형성된 지지체 상에 매개층을 활용하여 나노 사이즈의 금 콜로이드를 흡착시킴으로서 SPR 감도를 크게 증가시킬 수 있으며, 그에 따라 소량의 시료를 사용하여도 고감도로 물질 분석이 가능한 표면 플라즈몬 공명 기술을 이용한 센서칩용 나노금속 콜로이드 기판의 제조방법과 이를 포함하는 센서칩을 제공한다.