公开(公告)号：DE69331329D1

公开(公告)日：2002-01-24

申请号：DE69331329

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：PT663912E

公开(公告)日：2002-06-28

申请号：PT93923826

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： GARVEY DAVID S ,  ABREO MELWYN A ,  LIN NAN-HORNG ,  WASICAK JAMES T ,  LEBOLD SUZANNE A ,  ELLIOTT RICHARD L ,  GUNN DAVID E

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  C07D453/02

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：AT210656T

公开(公告)日：2001-12-15

申请号：AT93923826

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：AU687017B2

公开(公告)日：1998-02-19

申请号：AU5355794

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：CA2136075A1

公开(公告)日：1994-04-28

申请号：CA2136075

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  C07D453/02 ,  A61K31/425 ,  A61K31/435 ,  A61K31/495

Abstract: 2136075 9408992 PCTABS00032 Novel heterocyclic ether compounds of formula (I), wherein A, B and R2 are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：CA2315117C

公开(公告)日：2011-03-15

申请号：CA2315117

申请日：1998-12-18

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  GARVEY DAVID S ,  RYTHER KEITH ,  LEBOLD SUZANNE A ,  ELLIOTT RICHARD L ,  HE YUN ,  WASICAK JAMES T ,  BAI HAO ,  DART MICHAEL J ,  EHRLICH PAUL P ,  LI YIHONG ,  KINCAID JOHN F ,  SCHKERYANTZ JEFFREY M ,  LYNCH JOHN K

IPC: C07D401/12 ,  A61K31/40 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/50 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：ES2169727T3

公开(公告)日：2002-07-16

申请号：ES93923826

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  C07D453/02

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：CA2315117A1

公开(公告)日：1999-07-01

申请号：CA2315117

申请日：1998-12-18

Applicant: ABBOTT LAB

Inventor： HE YUN ,  LEBOLD SUZANNE A ,  ELLIOTT RICHARD L ,  BAI HAO ,  DART MICHAEL J ,  WASICAK JAMES T ,  KINCAID JOHN F ,  GARVEY DAVID S ,  LI YIHONG ,  RYTHER KEITH ,  HOLLADAY MARK W ,  EHRLICH PAUL P ,  ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  SCHKERYANTZ JEFFREY M ,  LYNCH JOHN K

IPC: A61K31/427 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04 ,  A61K31/40 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/50 ,  A61K31/505

Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceuticallyacceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.