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1.发明专利3-pyridyloxymethyl heterocyclic ether compound useful in controlling chemical synaptic transmission 审中-公开用于控制化学反应传输的3-吡啶基二甲基苯基醚化合物
公开(公告)号：JP2009256360A
公开(公告)日：2009-11-05
申请号：JP2009148236
申请日：2009-06-23
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： LIN NAN-HORNG , HE YUN , HOLLADAY MARK W , RYTHER KEITH , LI YIHONG , BAI HAO
IPC: C07D401/12 , A61K31/44 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/465 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P43/00 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14
CPC classification number: C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
Abstract: PROBLEM TO BE SOLVED: To provide a compound controlling synapse transmission in a neuron nicotinic cholinergic channel receptor, an intermediate for the synthesis of the compound, and a method for preparing a compound represented by formula (I) using the intermediate. SOLUTION: This compound is 5-(5,5-dimethyl-1,3-hexadienyl)-6-chloro-3-(2-(R)-pyrrolidinylmethoxy)pyridine or its pharmaceutically permissible salt in a 3-pyridyloxymethyl heterocyclic ether compound represented by formula (I). COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 待解决的问题：提供控制神经元烟碱胆碱通道受体中的突触传递的化合物，用于合成化合物的中间体，以及使用该中间体制备由式（I）表示的化合物的方法。 解决方案：该化合物是5-（5,5-二甲基-1,3-己二烯基）-6-氯-3-（2-（R） - 吡咯烷基甲氧基）吡啶或其药学上允许的盐，在3-吡啶氧基甲基 由式（I）表示的杂环醚化合物。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：AT273296T
公开(公告)日：2004-08-15
申请号：AT97927830
申请日：1997-06-04
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , HOLLADAY MARK W , RYTHER KEITH , LI YIHONG , BAI HAO
IPC: A61K31/44 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/465 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14
Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.
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公开(公告)号：PT1047690E
公开(公告)日：2004-07-30
申请号：PT98964167
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： ABREO MELWYN A , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , LEBOLD SUZANNE A , GUNN DAVID E , GARVEY DAVID S , ELLIOTT RICHARD L , HOLLADAY MARK W , RYTHER KEITH , HE YUN , WASIAK JAMES T , BAI HAO , EHRLICH PAUL P , LI YIHONG , KINCAID JOHN F , SCHKERYANTZ JEFFREY M
IPC: A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/50 , A61K31/505
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4.发明专利
公开(公告)号：ES2229364T3
公开(公告)日：2005-04-16
申请号：ES97927830
申请日：1997-06-04
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , HOLLADAY MARK W , RYTHER KEITH , LI YIHONG , BAI HAO
IPC: A61K31/44 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/465 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14
Abstract: LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE ETER HETEROCICLICO DE 3 - PIRIDILOXIMETILO DE FORMULA (I) O A LAS SALES FARMACEUTICAMENTE ACEPTABLES O PROFARMACOS DE LOS MISMOS, QUE SON LIGANDOS SELECTIVOS Y POTENTES EN LOS RECEPTORES DE LOS CANALES COLINERGICOS NICOTINICOS NEURONALES, Y SON EFECTIVOS PARA CONTROLAR LA TRANSMISION SINAPTICA. SE DESCRIBEN ASIMISMO INTERMEDIARIOS Y PROCEDIMIENTOS CLAVE PARA PRODUCIR COMPUESTOS DE FORMULA (I), CON LAS VARIABLES DEFINIDAS EN LA DESCRIPCION.
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公开(公告)号：DE69822668T2
公开(公告)日：2005-03-10
申请号：DE69822668
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： HOLLADAY W , ABREO A , GUNN E , LIN NAN-HORNG , GARVEY S , RYTHER KEITH , LEBOLD A , ELLIOTT L , HE YUN , WASIAK T , BAI HAO , DART J , EHRLICH P , LI YIHONG , KINCAID F , SCHKERYANTZ M , LYNCH K
IPC: A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/50 , A61K31/505
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Patent Agency Ranking
公开(公告)号：PT934308E
公开(公告)日：2004-11-30
申请号：PT97927830
申请日：1997-06-04
Applicant: ABBOTT LAB
Inventor： BAI HAO , LIN NAN-HORNG , HE YUN , HOLLADAY MARK W , RYTHER KEITH , LI YIHONG
IPC: A61K31/44 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/465 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14
Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.
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公开(公告)号：DE69822668D1
公开(公告)日：2004-04-29
申请号：DE69822668
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： HOLLADAY W , ABREO A , GUNN E , LIN NAN-HORNG , GARVEY S , RYTHER KEITH , LEBOLD A , ELLIOTT L , HE YUN , WASIAK T , BAI HAO , DART J , EHRLICH P , LI YIHONG , KINCAID F , SCHKERYANTZ M , LYNCH K
IPC: A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/50 , A61K31/505
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公开(公告)号：DK0934308T3
公开(公告)日：2004-12-06
申请号：DK97927830
申请日：1997-06-04
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , HOLLADAY MARK W , RYTHER KEITH , LI YIHONG , BAI HAO
IPC: A61K31/44 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/465 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14
Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.
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公开(公告)号：AT262519T
公开(公告)日：2004-04-15
申请号：AT98964167
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , GARVEY DAVID S , RYTHER KEITH , LEBOLD SUZANNE A , ELLIOTT RICHARD L , HE YUN , WASIAK JAMES T , BAI HAO , DART MICHAEL J , EHRLICH PAUL P , LI YIHONG , KINCAID JOHN F , SCHKERYANTZ JEFFREY M , LYNCH JOHN K
IPC: A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04 , A61K31/40 , A61K31/425 , A61K31/44
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公开(公告)号：AR034538A1
公开(公告)日：2004-03-03
申请号：ARP000100393
申请日：2000-01-28
Applicant: ABBOTT LAB
Inventor： BRUNNELLE WILLIAM , DART MICHAEL , SCHRIMPF MICHAEL , BARLOCCO CRISTINA , MEYER MICHAEL , SIPPY KEVIN , DAANEN JEROME , RYTHER KEITH , TOUPENCE RICHARD
IPC: A61K31/00 , A61K31/407 , A61K31/4355 , A61K31/4365 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/395
Abstract: Un compuesto diazabicíclico N-substituido caracterizado porque es de fórmula (1) o una sal aceptable para uso farmacéutico del mismo, en el cual: V se selecciona del grupo formado por un enlace covalente y CH2; W se selecciona del grupo formado por un enlace covalente, CH2 y CH2CH2; X se selecciona del grupo formado por un enlace covalente y CH2; Y se selecciona del grupo formado por un enlace covalente, CH2 y CH2CH2; Z se selecciona del grupo formado por CH2, CH2CH2 y CH2CH2CH2; L1 se selecciona del grupo formado por un enlace covalente y (CH2)n; n es 1-5; R1 se selecciona del grupo formado por los restos de fórmulas (2) a (13); R2 se selecciona del grupo formado por hidrógeno, alcoxicarbonilo, alquilo, aminoalquilo, aminocarbonilalquilo, benciloxicarbonilo, cianoalquilo, dihidropiridin-3-ilcarbonilo, hidroxi, hidroxialquilo, fenoxicarbonilo y -NH2; R4 se selecciona del grupo formado por hidrógeno, alquilo y halógeno; R5 se selecciona del grupo formado por hidrógeno, alcoxi, alquilo, halógeno, nitro y -NH2; R6 se selecciona del grupo formado por hidrógeno, alquenilo, alcoxi, alcoxialcoxi, alcoxialquilo, alcoxicarbonilo, alcoxicarbonilalquilo, alquilo, alquilcarbonilo, alquilcarboniloxi, alquiltio, alquinilo, amino, aminoalquilo, aminocarbonilo, aminocarbonilalquilo, aminosulfonilo, carboxi, carboxialquilo, ciano, cianoalquilo, formilo, formilalquilo, haloalcoxi, haloalquilo, halógeno, hidroxi, hidroxialquilo, mercapto, mercaptoalquilo, nitro, 5-tetrazolilo, -NR7SO2R8, -C(NR7)NR7R8, -CH2C(NR7)NR7R8, -C(NOR7)R8, -C(NCN)R7, -C(NNR7R8)R8, -S(O)2OR7 y -S(O)2R7; y R7 y R8 se seleccionan independientemente del grupo formado por hidrógeno y alquilo; siempre que se excluyan los siguientes compuestos: 3-(6-cloro-3-piridazinil)-3,8-diazabiciclo[3.2.1]octano; 3-(6-cloro-2-pirazinil)-3,8-diazabiciclo[3.2.1]octano; 8-(6-cloro-3-piridazinil)-3,8-diazabiciclo[3.2.1]octano; y 8-(6-cloro-2-pirazinil)-3,8-diazabiciclo[3.2.1]octano; y con la condición adicional de que siempre que V y X sean cada uno un enlace covalente, W, Y y Z sean cada uno CH2; y L1 un enlace covalente, entonces R1 es distinto del resto de fórmula (4). Dichos compuestos forman parte de composiciones farmacéuticas y son usados en la fabricación de medicamentos útiles para el control selectivo de la liberación de neurotransmisores y otras afecciones en mamíferos.
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