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    Method of identifying inhibitors of lck
    12.
    发明专利
    Method of identifying inhibitors of lck 未知

    公开(公告)号：AU2002327422A1

    公开(公告)日：2003-03-18

    申请号：AU2002327422

    申请日：2002-08-02

    Applicant: ABBOTT LAB

    Inventor： HIRST GAVIN C ,  RITTER KURT ,  LOEW ANDREAS ,  CALDERWOOD DAVID ,  HRNCIAR PETER ,  DIXON RICHARD W ,  BORHANI DAVID W ,  LEUNG ADELAINE

    IPC: C12N9/12 ,  C07K14/00 ,  A61K38/16

    Abstract: The present invention relates to polypeptides which comprise the ligand binding domain of Lck, crystalline forms of these polypeptides, and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Lck. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential selective inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain selectively.

    COMPOSICIONES Y METODOS PARA CRISTALIZAR ANTICUERPOS.
    15.
    发明专利
    COMPOSICIONES Y METODOS PARA CRISTALIZAR ANTICUERPOS. 未知

    公开(公告)号：MX2010001488A

    公开(公告)日：2010-03-01

    申请号：MX2010001488

    申请日：2008-08-08

    Applicant: ABBOTT LAB

    Inventor： BORHANI DAVID W ,  WINTER GERHARD ,  FRAUNHOFER WOLFGANG ,  GOTTSCHALK STEFAN

    IPC: A61K39/395

    Abstract: La presente invención se refiere a un método de cristalización por lotes, para cristalizar un anticuerpo y fragmentos de anticuerpo TNFalfa anti-humano (hTNFalfa), el cual permite la producción del anticuerpo en una escala industrial; a un método para controlar el tamaño de los cristales del anticuerpo. Por ejemplo, cristales de fragmentos de anticuerpo anti-hTNFalfa, a composiciones que contienen dichos cristales, así como a métodos de uso de dichos cristales y composiciones.

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