公开(公告)号：WO2008063287A3

公开(公告)日：2008-08-07

申请号：PCT/US2007021497

申请日：2007-10-05

Applicant: ABBOTT LAB ,  BORHANI DAVID W ,  CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  DAVIS HEATHER M ,  JOSEPHSOHN NATHAN S ,  SKINNER BARBARA S

Inventor： BORHANI DAVID W ,  CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  DAVIS HEATHER M ,  JOSEPHSOHN NATHAN S ,  SKINNER BARBARA S

IPC: A61K31/41 ,  C07D257/04

CPC classification number: C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Abstract translation: 本发明涉及新的式（I）化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如癌症。

公开(公告)号：EP2068869A4

公开(公告)日：2011-05-25

申请号：EP07870771

申请日：2007-10-05

Applicant: ABBOTT LAB

Inventor： BORHANI DAVID W ,  CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  DAVIS HEATHER M ,  JOSEPHSOHN NATHAN S ,  SKINNER BARBARA S

IPC: A61K31/41 ,  C07D257/04

CPC classification number: C07D498/04 ,  C07D513/04 ,  C07D519/00

公开(公告)号：MX2009003650A

公开(公告)日：2009-04-22

申请号：MX2009003650

申请日：2007-10-05

Applicant: ABBOTT LAB

Inventor： CALDERWOOD DAVID J ,  DAVIS HEATHER M ,  FRANK KRISTINE E ,  BORHANI DAVID W ,  JOSEPHSOHN NATHAN S ,  SKINNER BARBARA S

IPC: C07D513/04 ,  A61K31/424 ,  A61K31/429 ,  A61K31/437 ,  A61K31/4439 ,  C07D498/04

Abstract: La presente invención se refiere a nuevos compuestos de la Fórmula (I), en donde las variables son como las aquí definidas. Los compuestos de la Fórmula (I) son útiles como inhibidores de cinasa y, como tales, serian útiles en el tratamiento de ciertos trastornos y enfermedades, especialmente trastornos y enfermedades inflamatorias y trastornos y enfermedades proliferativas, por ejemplo cánceres.

公开(公告)号：DK1648905T3

公开(公告)日：2009-03-30

申请号：DK04779180

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：CA2532982C

公开(公告)日：2013-11-26

申请号：CA2532982

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula: (I), are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：SI1648905T1

公开(公告)日：2009-06-30

申请号：SI200431056

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/00 ,  A61K31/00 ,  A61P35/00 ,  C07D491/00 ,  C07D491/04 ,  C07D495/04 ,  C07D498/00

公开(公告)号：CA2532982A1

公开(公告)日：2005-02-03

申请号：CA2532982

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  HEYMAN HOWARD R ,  MUCKEY MELANIE A ,  HIRST GAVIN C ,  RAFFERTY PAUL ,  BETSCHMANN PATRICK ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  WADA CAROL K ,  FREY ROBIN R

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula: (I), are useful for inhibiting protein tyrosin e kinases. The present invention also discloses methods of making the compound s, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：CY1111599T1

公开(公告)日：2015-10-07

申请号：CY091100278

申请日：2009-03-12

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Ενώσειςπουέχουντονχημικότύπο: (I), είναιχρήσιμεςγιατηναναστολήκινασώντυροσίνηςπρωτεΐνης. Στηνπαρούσαεφεύρεσηαποκαλύπτονταικαιδημοσιοποιούνταιωςαναφοράεπίσηςμέθοδοιγιατηνπαρασκευήτωνενώσεων, τωνσυνθέσεωνπουπεριέχουντιςενώσεις, καιτωνμεθόδωναγωγήςχρησιμοποιώνταςτιςενώσεις.

公开(公告)号：NZ544712A

公开(公告)日：2009-09-25

申请号：NZ54471204

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Disclosed are compounds of formula (I) wherein: X is S; Z is C; R1 and R3 are as described in the specification; and R2 is hydrogen or alkyl. Compounds of the type disclosed are tyrosine kinase inhibitors useful in the treatment of cancer.

公开(公告)号：BRPI0412894A

公开(公告)日：2006-10-03

申请号：BRPI0412894

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: A61P35/00 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  A61K31/4355 ,  A61K31/4365

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.