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公开(公告)号：SE331101B
公开(公告)日：1970-12-14
申请号：SE886268
申请日：1968-06-28
Applicant: ABBOTT LAB
Inventor： JONES P
IPC: C07H17/08
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公开(公告)号：ZA765510B
公开(公告)日：1977-08-31
申请号：ZA765510
申请日：1976-09-14
Applicant: ABBOTT LAB
IPC: A61K31/41 , A61K31/19 , A61P9/12 , C07C45/46 , C07C45/67 , C07C49/84 , C07C51/00 , C07C59/125 , C07C59/90 , C07C67/00 , C07C205/45 , C07D257/04 , C07D
Abstract: This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R1 is -CH2COOH or methyl tetrazole, and X1 and X2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring.
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公开(公告)号：PH12894A
公开(公告)日：1979-10-04
申请号：PH18922
申请日：1976-09-17
Applicant: ABBOTT LAB
IPC: A61K31/41 , A61K31/19 , A61P9/12 , C07C45/46 , C07C45/67 , C07C49/84 , C07C51/00 , C07C59/125 , C07C59/90 , C07C67/00 , C07C205/45 , C07D257/04 , C07C59/26
Abstract: This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R1 is -CH2COOH or methyl tetrazole, and X1 and X2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring.
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公开(公告)号：ZA7605510B
公开(公告)日：1977-08-31
申请号：ZA7605510
申请日：1976-09-14
Applicant: ABBOTT LAB
IPC: A61K31/19 , A61K31/41 , A61P9/12 , C07C45/46 , C07C45/67 , C07C49/84 , C07C51/00 , C07C59/125 , C07C59/90 , C07C67/00 , C07C205/45 , C07D257/04 , C07D
CPC classification number: C07D257/04 , C07C45/46 , C07C45/673 , C07C49/84 , C07C59/90 , C07C205/45 , Y10S514/869 , C07C49/83
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公开(公告)号：ZA765071B
公开(公告)日：1977-04-27
申请号：ZA765071
申请日：1975-08-06
Applicant: ABBOTT LAB , CHAMBER OF MINES SERVICES LTD
IPC: C07C20060101 , C07C
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Patent Agency Ranking
公开(公告)号：ZA7605071B
公开(公告)日：1977-04-27
申请号：ZA7605071
申请日：1975-08-06
Applicant: ABBOTT LAB , CHAMBER OF MINES SERVICES LTD
IPC: C07C20060101 , C07C
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公开(公告)号：PH10395A
公开(公告)日：1977-03-04
申请号：PH15865
申请日：1974-05-27
Applicant: ABBOTT LAB
Inventor： JONES P , MARTIN J , TADANIER J , MCALPINE J , PAULIK J
Abstract: 1463850 4 11 -Dioxy-4-oxo-erythromycin B derivatives ABBOTT LABORATORIES 19 June 1974 [21 June 1973] 27249/74 Heading C2C Novel compounds I and II in which R 5 is CH(R 7 )-SR 8 (where R 7 is hydrogen or C 1-6 alkyl and R 8 is C 1-6 alkyl) and R 6 is hydrogen or C 2-6 alkanoyl provided that when R 6 is hydrogen then R 5 is also hydrogen are prepared by reacting erythromycin B with a di-C 1-6 alkyl-sulphoxide and C 2-6 alkanoic acid anhydride to form a compound I (R 5 = CH(R 7 )-SR 8 and R 6 = C 2-6 alkanoyl) which is hydrolysed with an alkali metal bicarbonate to form a compound I (R 5 =CH(R 7 )-SR 8 and R 6 = hydrogen) which in the presence of HgO/ HgCl 2 forms a compound II which is hydrolysed by dil. HCl to compound I (R 5 = R 6 = hydrogen). Compound I (R 5 =R 6 =hydrogen) is also prepared by treating compound II with chloramine T.
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公开(公告)号：ZA7406331B
公开(公告)日：1975-12-31
申请号：ZA7406331
申请日：1974-10-04
Applicant: ABBOTT LAB
IPC: A61K31/195 , A01N37/44 , A61K31/198 , A61K31/22 , A61P9/08 , C07C237/08 , A61K , C07C
CPC classification number: A01N37/44 , Y10S514/929
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公开(公告)号：ZA746331B
公开(公告)日：1975-12-31
申请号：ZA746331
申请日：1974-10-04
Applicant: ABBOTT LAB
IPC: A61K31/195 , A01N37/44 , A61K31/198 , A61K31/22 , A61P9/08 , C07C237/08 , A61K , C07C
Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.
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