公开(公告)号：BRPI0811065A2

公开(公告)日：2014-12-02

申请号：BRPI0811065

申请日：2008-06-04

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： AKRITOPOULOU-ZANZE IRINI ,  WAKEFIELD BRIAN D ,  MACK HELMUT ,  TURNER SEAN C ,  GASIECKI ALAN F ,  GRACIAS VIJAVA J ,  SARRIS KATHY ,  KALVIN DOUGLAS M ,  MICHMERHUIZEN MELISSA J ,  SHUAI QI ,  PATEL JYOTI R ,  BAKKER MARGARETHA ,  TEUSCH NICOLE ,  JOHNSON ERIC F ,  KOVAR PETER J ,  DJURIC STEVAN W ,  LONG ANDREW J ,  VASUDEVAN ANIL ,  HOBSON ADRIAN ,  MOORE NIGEL ST JOHN ,  WANG LU ,  GEORGE DAWN ,  LI BIQIN ,  FRANK KRISTINE

IPC: C07D403/04 ,  C07D413/04 ,  C07D417/04

公开(公告)号：CA2689117A1

公开(公告)日：2008-12-18

申请号：CA2689117

申请日：2008-06-04

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： WAKEFIELD BRIAN D ,  AKRITOPOULOU-ZANZE IRINI ,  MACK HELMUT ,  FRANK KRISTINE ,  LI BIQIN ,  VASUDEVAN ANIL ,  HOBSON ADRIAN ,  LONG ANDREW J ,  DJURIC STEVAN W ,  KOVAR PETER J ,  JOHNSON ERIC T ,  TURNER SEAN C ,  GEORGE DAWN ,  GASIECKI ALAN F ,  WANG LU ,  ST JOHN MOORE NIGEL ,  MICHMERHUIZEN MELISSA J ,  GRACIAS VIJAYA J ,  SARRIS KATHY ,  KALVIN DOUGLAS M ,  SHUAI QI ,  PATEL JYOTI R ,  BAKKER MARGARETHA ,  TEUSCH NICOLE

IPC: C07D403/04 ,  C07D413/04 ,  C07D417/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutic al acceptable salts, wherein A, R1, R2, R3 and m, are defined in the descrip tion. The present invention relates also to methods of making said compounds , and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janu s Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

公开(公告)号：SI1560811T1

公开(公告)日：2007-12-31

申请号：SI200330987

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00

公开(公告)号：DE60315336D1

公开(公告)日：2007-09-13

申请号：DE60315336

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.