公开(公告)号：WO9009162A3

公开(公告)日：1990-11-29

申请号：PCT/US9000296

申请日：1990-01-16

Applicant: ABBOTT LAB

Inventor： KAWAI MEGUMI ,  OR YAT SUN ,  WIEDEMAN PAUL E ,  LULY JAY R ,  MOYER MIKEL P

IPC: C07D327/08 ,  A61K38/00 ,  A61P37/00 ,  C07D211/60 ,  C07D487/04 ,  C07D513/04 ,  C07K5/10 ,  C07K7/02 ,  C07K7/06 ,  C07K14/47 ,  A61K

CPC classification number: C07K14/472 ,  A61K38/00 ,  C07K7/02

Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q-T are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.

公开(公告)号：WO2004026822A3

公开(公告)日：2004-05-06

申请号：PCT/US0329018

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  A61K31/401 ,  A61K31/4439 ,  A61K31/506

CPC classification number: C07D207/27 ,  C07D207/16 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的式I化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖症，动脉粥样硬化和 各种免疫调节疾病。 或其药学上可接受的盐或前药，其中X，R，R 1，R 2和R 3具有说明书中给出的定义。

公开(公告)号：WO0218354A8

公开(公告)日：2002-07-04

申请号：PCT/US0126883

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： WIEDEMAN PAUL E ,  DJURIC STEVAN W ,  PLIUSHCHEV MARINA ,  SCIOTTI RICHARD J ,  MADAR DAVID J ,  KOPECKA HANA

IPC: A61P31/04 ,  C07D263/20 ,  C07D413/10 ,  C07D417/10 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/506

CPC classification number: C07D263/20 ,  C07D413/10 ,  C07D417/10

Abstract: Compounds of forumula (I) or therapeutically acceptable salts or prodrugs thereof, are useful for treating bacterial infections, psoriasis, arthritis, and toxicity due to chemotherapy. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.

Abstract translation: （I）或其治疗上可接受的盐或前药的化合物可用于治疗细菌感染，牛皮癣，关节炎和由于化疗引起的毒性。 公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。

公开(公告)号：EP0564533A4

公开(公告)日：1994-11-02

申请号：EP92902123

申请日：1991-12-10

Applicant: ABBOTT LAB

Inventor： KAWAI MEGUMI ,  WIEDEMAN PAUL E ,  LULY JAY R ,  OR YAT SUN

IPC: C07K5/02 ,  A61K38/00 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K7/02 ,  C07K7/06 ,  C07K14/47 ,  A61K37/02

CPC classification number: C07K7/02 ,  A61K38/00 ,  C07K14/472

公开(公告)号：DK1560811T3

公开(公告)日：2007-12-10

申请号：DK03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：PT1560811E

公开(公告)日：2007-11-14

申请号：PT03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： STEWART KENT D ,  SHAM HING L ,  MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

公开(公告)号：AU2003282800A1

公开(公告)日：2004-04-08

申请号：AU2003282800

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： SZCZEPANKIEWICZ BRUCE G ,  MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D

IPC: A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D207/00

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：CA2095359A1

公开(公告)日：1992-06-28

申请号：CA2095359

申请日：1991-12-10

Applicant: ABBOTT LAB

Inventor： WIEDEMAN PAUL E ,  KAWAI MEGUMI ,  LULY JAY R ,  OR YAT S ,  WAGNER ROLF

IPC: A61K38/00 ,  A61P37/08 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K7/02 ,  C07K7/06 ,  C07K14/47 ,  C07K7/00 ,  A61K38/04 ,  C07K5/00

Abstract: 2095359 9211858 PCTABS00014 Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.

公开(公告)号：DE60315336T2

公开(公告)日：2008-05-08

申请号：DE60315336

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：NZ538567A

公开(公告)日：2007-04-27

申请号：NZ53856703

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  A61K31/401 ,  A61K31/506 ,  A61K31/4439

Abstract: Compounds of formula (I), pharmaceutically acceptable salts and prodrugs thereof which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases are disclosed, wherein X, R, R1, R2 and R3 have the definitions given in the description.