公开(公告)号：AU646039B2

公开(公告)日：1994-02-03

申请号：AU7648191

申请日：1991-05-10

Applicant: ABBOTT LAB

Inventor： MIMMS LARRY T ,  FLOREANI MARCO F ,  EBLE KIM S ,  TYNER JOAN D ,  ROSENLOF ROBERT V ,  WITTERS ERIC

IPC: A61K39/395 ,  A61K49/00 ,  C07K16/08 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/569 ,  G01N33/576 ,  G01N33/577 ,  A61K39/44

Abstract: Murine monoclonal antibodies are provided which bind specifically to the PreS1 and PreS2 polypeptides of the hepatitis B virus surface antigen (HBsAg) complex and which are useful to assay for PreS1 or PreS2 in samples of physiological material. The antibodies can also be used to subtype HBV, to raise the immunogenicity of blood plasma against HBV, to measure anti-PreS1 and anti-PreS2 antibodies, and to identify and characterize antigenic epitopes of PreS1 and PreS2 which may be useful in HBV subunit vaccines.

公开(公告)号：CA2128203A1

公开(公告)日：1993-10-14

申请号：CA2128203

申请日：1992-03-31

Applicant: ABBOTT LAB

Inventor： TASKAR SUHAS ,  CLEMENS JOHN M ,  MIMMS LARRY T ,  CHAU KURT H ,  VALLARI DAVID S

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N1/34

Abstract: 2128203 9320445 PCTABS00027 An assay for determining the presence of HCV IgM in a test sample. A test sample is contacted with at least one HCV antigen, incubated to form antigen/antibody complexes, and then contacted with an indicator reagent in order to produce a detectable signal. The amount of HCV IgM present in the test sample is proportional to the signal generated. The assay also can include the step of contacting the complexes with an enhancer compound prior to the use of an indicator reagent. Also provided is a test kit useful for performing the assay of the invention.

公开(公告)号：AU1362792A

公开(公告)日：1992-09-07

申请号：AU1362792

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12N5/00 ,  C12Q1/70

Abstract: Monoclonal antibodies which specifically bind to putative Hepatitis C Virus (HCV) envelope region. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

公开(公告)号：CA2101534A1

公开(公告)日：1992-08-01

申请号：CA2101534

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12N5/18

Abstract: 2101534 9213892 PCTABS00014 Monoclonal antibodies which specifically bind to putative Hepatitis C Virus (HCV) envelope region. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

公开(公告)号：AU9077791A

公开(公告)日：1992-06-11

申请号：AU9077791

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C07K15/00 ,  C12Q1/70 ,  C12P21/02 ,  C12N5/00

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：CA2162132C

公开(公告)日：2001-12-11

申请号：CA2162132

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C07H21/00 ,  C07K19/00 ,  C12N7/04 ,  C07K16/08

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety o f diagnostic and therapeutic applications, kits for usin g the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic aci d sequences.

公开(公告)号：GR3030212T3

公开(公告)日：1999-08-31

申请号：GR990401297

申请日：1999-05-13

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C07K16/08 ,  C12Q1/70 ,  C12P21/02 ,  C12N5/00

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：ES2118129T3

公开(公告)日：1998-09-16

申请号：ES92906219

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12N5/20

Abstract: Monoclonal antibodies which specifically bind to putative Hepatitis C Virus (HCV) envelope region. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

公开(公告)号：DE69028561T2

公开(公告)日：1997-04-17

申请号：DE69028561

申请日：1990-03-07

Applicant: ABBOTT LAB

Inventor： DAWSON GEORGE J ,  MIMMS LARRY T ,  WOOD CHARLES ,  WU PING ,  ROSER MICHELLE A

IPC: G01N33/569

Abstract: The invention is an improved diagnostic immunoassay for the detection of human sera antibodies specific for human immunodeficiency virus (HIV). The immunoassay utilizes two detection systems which are designed to detect antibodies to two distinct proteins of HIV. One detection system is designed to detect antibodies to surface proteins of HIV, and the other is designed to detect antibodies to core proteins of HIV.

公开(公告)号：DE69028561D1

公开(公告)日：1996-10-24

申请号：DE69028561

申请日：1990-03-07

Applicant: ABBOTT LAB

Inventor： DAWSON GEORGE J ,  MIMMS LARRY T ,  WOOD CHARLES ,  WU PING ,  ROSER MICHELLE A

IPC: G01N33/569

Abstract: The invention is an improved diagnostic immunoassay for the detection of human sera antibodies specific for human immunodeficiency virus (HIV). The immunoassay utilizes two detection systems which are designed to detect antibodies to two distinct proteins of HIV. One detection system is designed to detect antibodies to surface proteins of HIV, and the other is designed to detect antibodies to core proteins of HIV.