公开(公告)号：AT368647T

公开(公告)日：2007-08-15

申请号：AT03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN ,  WIEDEMAN PAUL ,  YONG HONG ,  MICHMERHUIZEN MELISSA ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING ,  STEWART KENT ,  SZCZEPANKIEWICZ BRUCE

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：CA2103454C

公开(公告)日：2004-11-02

申请号：CA2103454

申请日：1992-09-08

Applicant: ABBOTT LAB

Inventor： LULY JAY R ,  KAWAI MEGUMI ,  OR YAT S ,  WIEDEMAN PAUL ,  WAGNER ROLF

IPC: A61K31/435 ,  A61K31/365 ,  A61P1/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P17/14 ,  A61P21/04 ,  A61P29/00 ,  A61P37/06 ,  C07D487/14 ,  C07D491/056 ,  C07D491/08 ,  C07D491/153 ,  C07D491/18 ,  C07D491/20 ,  C07D498/04 ,  C07D498/08 ,  C07D498/14 ,  C07D498/18 ,  C07D498/22 ,  C07D513/14 ,  C07D513/18 ,  C07F7/18 ,  C07F9/6561 ,  C07H19/01 ,  C12P17/16 ,  C12R1/465 ,  C07H23/00 ,  A61K31/395 ,  A61K31/695 ,  A61K31/70

Abstract: Immunomodulatory macrocylic compounds having the formula (VII) and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is selected from one of the formulae (Ia), (Ib) and (Ic), as well as pharmaceutical compositions containing the same.

公开(公告)号：ES2179823T3

公开(公告)日：2003-02-01

申请号：ES92920494

申请日：1992-09-08

Applicant: ABBOTT LAB

Inventor： LULY JAY R ,  KAWAI MEGUMI ,  OR YAT SUN ,  WIEDEMAN PAUL ,  WAGNER ROLF

IPC: A61K31/435 ,  A61K31/365 ,  A61P1/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P17/14 ,  A61P21/04 ,  A61P29/00 ,  A61P37/06 ,  C07D487/14 ,  C07D491/056 ,  C07D491/08 ,  C07D491/153 ,  C07D491/18 ,  C07D491/20 ,  C07D498/04 ,  C07D498/08 ,  C07D498/14 ,  C07D498/18 ,  C07D498/22 ,  C07D513/14 ,  C07D513/18 ,  C07F7/18 ,  C07F9/6561 ,  C07H19/01 ,  C12P17/16 ,  C12R1/465 ,  A61K31/395 ,  A61K31/33 ,  A61K31/70

Abstract: PCT No. PCT/US92/07593 Sec. 371 Date Mar. 7, 1994 Sec. 102(e) Date Mar. 7, 1994 PCT Filed Sep. 8, 1992 PCT Pub. No. WO93/04679 PCT Pub. Date Mar. 18, 1993Immunomodulatory macrocyclic compounds having the formula (VII) and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is a group having the formula (Ic) as well as pharmaceutical compositions containing the same.

公开(公告)号：AT218570T

公开(公告)日：2002-06-15

申请号：AT92920494

申请日：1992-09-08

Applicant: ABBOTT LAB

Inventor： LULY JAY R ,  KAWAI MEGUMI ,  OR YAT SUN ,  WIEDEMAN PAUL ,  WAGNER ROLF

IPC: A61K31/435 ,  A61K31/365 ,  A61P1/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P17/14 ,  A61P21/04 ,  A61P29/00 ,  A61P37/06 ,  C07D487/14 ,  C07D491/056 ,  C07D491/08 ,  C07D491/153 ,  C07D491/18 ,  C07D491/20 ,  C07D498/04 ,  C07D498/08 ,  C07D498/14 ,  C07D498/18 ,  C07D498/22 ,  C07D513/14 ,  C07D513/18 ,  C07F7/18 ,  C07F9/6561 ,  C07H19/01 ,  C12P17/16 ,  C12R1/465 ,  A61K31/395 ,  A61K31/33 ,  A61K31/70

Abstract: PCT No. PCT/US92/07593 Sec. 371 Date Mar. 7, 1994 Sec. 102(e) Date Mar. 7, 1994 PCT Filed Sep. 8, 1992 PCT Pub. No. WO93/04679 PCT Pub. Date Mar. 18, 1993Immunomodulatory macrocyclic compounds having the formula (VII) and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is a group having the formula (Ic) as well as pharmaceutical compositions containing the same.

公开(公告)号：CA2103453A1

公开(公告)日：1993-03-06

申请号：CA2103453

申请日：1992-09-08

Applicant: ABBOTT LAB

Inventor： LULY JAY R ,  KAWAI MEGUMI ,  OR YAT SUN ,  WIEDEMAN PAUL ,  WAGNER ROLF

IPC: A61K31/435 ,  A61K31/365 ,  A61P1/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P17/14 ,  A61P21/04 ,  A61P29/00 ,  A61P37/06 ,  C07D487/14 ,  C07D491/056 ,  C07D491/08 ,  C07D491/153 ,  C07D491/18 ,  C07D491/20 ,  C07D498/04 ,  C07D498/08 ,  C07D498/14 ,  C07D498/18 ,  C07D498/22 ,  C07D513/14 ,  C07D513/18 ,  C07F7/18 ,  C07F9/6561 ,  C07H19/01 ,  C12P17/16 ,  C12R1/465 ,  C07H23/00 ,  A61K31/395 ,  A61K31/695 ,  A61K31/70

Abstract: 2103453 9304679 PCTABS00020 Immunomodulatory macrocyclic compounds having formula (VII), and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is a group having formula (Ic), as well as pharmaceutical compositions containing the same.