公开(公告)号：EP2250162A2

公开(公告)日：2010-11-17

申请号：EP09707625.1

申请日：2009-02-06

Applicant: Abbott Laboratories

Inventor： MORTELL, Kathleen H. ,  NERSESIAN, Diana L. ,  SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  GOPALAKRISHNAN, Murali

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07D209/08 ,  C07D403/12 ,  C07D471/04

Abstract: The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.

公开(公告)号：EP2525797A1

公开(公告)日：2012-11-28

申请号：EP10801767.4

申请日：2010-12-22

Applicant: Abbott Laboratories

Inventor： LEE, CHIH-Hung ,  SCHRIMPF, Michael R. ,  ESBENSHADE, Timothy A. ,  ZHU, Chang Z.

IPC: A61K31/55 ,  A61K45/06 ,  A61P23/00

CPC classification number: A61K31/46 ,  A61K31/55 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention is directed to methods of treating pain by administering a therapeutically effective amount of an α7 nAChR ligand or a pharmaceutically acceptable salt thereof, to a mammal in need of treatment thereof and to pharmaceutical compositions comprising such a compound or salt.

公开(公告)号：EP1824848A1

公开(公告)日：2007-08-29

申请号：EP04813737.6

申请日：2004-12-10

Applicant: ABBOTT LABORATORIES

Inventor： JI, Jianguo ,  LI, Tao ,  MORTELL, Kathleen H. ,  SCHRIMPF, Michael R. ,  NERSESIAN, Diana L. ,  PAN, Liping

IPC: C07D453/02 ,  A61K31/439 ,  A61P25/28

CPC classification number: C07D453/02

Abstract: Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+-O-; X is O, S, -NH-, and -N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by a7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：EP2101763B1

公开(公告)日：2012-07-18

申请号：EP07869109.4

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES

Inventor： GOPALAKRISHNAN, Murali ,  HONORE, Marie P. ,  LEE, Chih-hung ,  MALYSZ, John ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael R. ,  SIPPY, Kevin B. ,  ANDERSON, David J.

IPC: A61K31/4245 ,  A61P25/28 ,  A61K45/06

CPC classification number: A61K31/4439 ,  A61K31/4245 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  G01N33/944 ,  G01N2333/70571 ,  A61K2300/00

Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.

公开(公告)号：EP2344505A2

公开(公告)日：2011-07-20

申请号：EP09793046.5

申请日：2009-09-28

Applicant: Abbott Laboratories

Inventor： SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana ,  HU, Min

IPC: C07D487/18 ,  A61K31/33 ,  A61P25/00

CPC classification number: G01N33/5058 ,  C07D471/18 ,  C07D487/10 ,  C07D487/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R
1 , R
2 , R
3 , R
4 , R
5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：EP2114943A1

公开(公告)日：2009-11-11

申请号：EP07854782.5

申请日：2007-11-27

Applicant: ABBOTT LABORATORIES

Inventor： JI, Jianguo ,  SCHRIMPF, Michael R. ,  SIPPY, Kevin B ,  LI, Tao ,  LEE, Chih-hung

IPC: C07D471/18 ,  A61K31/395 ,  A61P25/02 ,  A61P25/28

CPC classification number: C07D471/18

Abstract: The invention relates to compounds that are spirocyclic azaadamantane derivatives (I), particularly spirocyclic, azaadamantanyl ether or amine derviatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.