中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

21 records (took 0.024 seconds)

    ULTRA-LOW VOLUME FRACTION COLLECTION AND ANALYSIS
    11.
    发明申请
    ULTRA-LOW VOLUME FRACTION COLLECTION AND ANALYSIS 审中-公开
    超低体积分数收集和分析

    公开(公告)号：WO2006086292A3

    公开(公告)日：2007-10-04

    申请号：PCT/US2006004071

    申请日：2006-02-07

    Applicant: ADVION BIOSCIENCES INC

    Inventor： CORSO THOMAS N ,  VAN PELT COLLEEN K ,  LI JIE

    IPC: G01N1/00

    CPC classification number: G01N30/80 ,  B01L3/0275 ,  B01L3/0293 ,  B01L2300/0838 ,  G01N35/10 ,  G01N35/1016 ,  G01N2035/103 ,  G01N2035/1039 ,  G01N2035/1053 ,  G01N2035/1055 ,  Y10T436/2575

    Abstract: An ultra-low volume fraction collection and concentration method provides practical application in collecting fractions, e.g. as low as 25 nL, from nanoLC columns into pipette tips at user-defined timed-intervals. The fractions are dried to create a concentrated band at the very end of the interior of the pipette tip and subsequently reconstituted directly in the pipette tips in solvent prior to analysis. As the chromatography and reconstitution solvent choice are independent, the reconstitution solvent can be selected to maximize ionization efficiency without compromising chromatography separation, hi the infusion analysis of the nanoLC fractions, a low flow electrospray chip enables each nanoLC fraction to be analyzed for over ten minutes. This increase in analysis time allows for advantages over prior methods. Optionally, the nanoLC fractions can be archived in the pipette tips for analysis at a later date.

    Abstract translation: 超低体积分数收集和浓缩方法提供了实际应用于收集级分，例如。 低至25 nL，由用户定义的定时间隔从nanoLC色谱柱移至吸头。 将级分干燥以在移液管尖端内部的最末端产生浓缩带，随后在分析之前将其直接重新配置在溶剂中的吸头中。 由于色谱和重构溶剂选择是独立的，所以可以选择重构溶剂以使离子化效率最大化而不影响色谱分离。在纳米级分的输注分析中，低流电喷雾芯片使得每个纳米LC部分能够分析十分钟 。 分析时间的这种增加允许优于现有方法的优点。 任选地，nanoLC部分可以存档在移液管尖端中以供日后分析。

    INTEGRATED MONOLITHIC MICROFABRICATED DISPENSING NOZZLE AND LIQUID CHROMATOGRAPHY-ELECTROSPRAY SYSTEM AND METHOD
    13.
    发明专利
    INTEGRATED MONOLITHIC MICROFABRICATED DISPENSING NOZZLE AND LIQUID CHROMATOGRAPHY-ELECTROSPRAY SYSTEM AND METHOD 未知

    公开(公告)号：CA2363414C

    公开(公告)日：2008-02-05

    申请号：CA2363414

    申请日：2000-02-29

    Applicant: ADVION BIOSCIENCES INC

    Inventor： CORSO THOMAS N ,  SCHULTZ GARY A ,  GALVIN GREGORY J ,  DAVIS TIMOTHY J ,  MOON JAMES E

    IPC: B05B5/025 ,  B81C1/00 ,  G01N27/26 ,  G01N27/447 ,  G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10

    Abstract: A droplet/electrospray device and a liquid chromatography-electrospray system are disclosed. The droplet/electrospray device (100) comprises a substrate (102) defining a channel (104) between an entrance orifice (106) on an injection surface (108) and an exit orifice on an ejection surface (112), a nozzle (110) defined by a portion recessed from the ejection surface (112) surrounding the exit orifice, and an electrode (122) for application of an electric potential to the substrate (102) to optimize and generate droplets or an electrospray (62). A plurality of these electrospray devices (100) can be used in the fonn of an array of miniaturized nozzles. The liquid chromatography-electrospray device (160) comprises a separation substrate (162) defining an introduction channel (164) between an entrance orifice and a reservoir (166) and a separation channel (168) between the reservoir (166) and an exit orifice (170), the separation channel (168) being populated with separation posts (174) perpendicular to the fluid flow.

    Liquid chromatography system
    14.
    发明专利
    Liquid chromatography system 未知

    公开(公告)号：HK1066863A1

    公开(公告)日：2005-04-01

    申请号：HK04109844

    申请日：2004-12-13

    Applicant: ADVION BIOSCIENCES INC ,  KIONIX INC

    Inventor： MOON JAMES E ,  SCHULTZ GARY A ,  CORSO THOMAS N ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J ,  LOWES STEPHEN

    IPC: G01N20060101 ,  B01D20060101 ,  G01N27/62 ,  B01D15/08 ,  G01N30/60 ,  G01N30/72 ,  G01N37/00 ,  H01J20060101 ,  H01J49/04

    Abstract: An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS
    16.
    发明公开
    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS 有权
    多电喷涂设备，系统和方法

    公开(公告)号：EP1269518A4

    公开(公告)日：2006-06-28

    申请号：EP00988285

    申请日：2000-12-22

    Applicant: ADVION BIOSCIENCES INC

    Inventor： SCHULTZ GARY A ,  CORSO THOMAS N ,  PROSSER SIMON J

    IPC: G01N27/62 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

    CPC classification number: H01J49/167 ,  H01J49/0018 ,  H01J49/04

    Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device (250) includes a substrate (200) defining a channel (224) between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle (232) defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray (262). A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices (232) can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes (262) from multiple nozzles (232) for the same fluid stream . This invention dramatically increases the sensitivity of microchip electrospray devices (250) compared to prior disclosed systems and methods.

    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP
    17.
    发明公开
    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP 审中-公开
    用于自动电的机器人自动取样装置喷射从一个微电子芯片的油液

    公开(公告)号：EP1383592A4

    公开(公告)日：2007-02-21

    申请号：EP02706034

    申请日：2002-01-28

    Applicant: ADVION BIOSCIENCES INC

    Inventor： PROSSER SIMON J ,  RULE GEOFFREY S ,  SCHULTZ GARY A ,  CORSO THOMAS N

    IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

    CPC classification number: G01N35/10 ,  G01N35/0099 ,  G01N35/04 ,  G01N2035/00158 ,  G01N2035/0491 ,  G01N2035/1034 ,  H01J49/0413 ,  H01J49/165

    Abstract: A robotic autosampler (1) provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler having an electrospray chip (80); electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

    INTEGRATED MONOLITHIC MICROFABRICATED DISPENSING NOZZLE AND LIQUID CHROMATOGRAPHY-ELECTROSPRAY SYSTEM AND METHOD
    20.
    发明公开
    INTEGRATED MONOLITHIC MICROFABRICATED DISPENSING NOZZLE AND LIQUID CHROMATOGRAPHY-ELECTROSPRAY SYSTEM AND METHOD 审中-公开
    集成的单片微加工配送喷嘴和FLÜSSIGKEITSCHROMATOGRAHPIE - 电喷雾系统和方法

    公开(公告)号：EP1163512A4

    公开(公告)日：2007-08-08

    申请号：EP00913655

    申请日：2000-02-29

    Applicant: ADVION BIOSCIENCES INC ,  KIONIX INC

    Inventor： SCHULTZ GARY A ,  CORSO THOMAS N ,  MOON JAMES E ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J

    IPC: G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10

    CPC classification number: H01J49/167 ,  G01N30/6095 ,  G01N30/7266 ,  H01J49/0018

    Abstract: A droplet/electrospray device and a liquid chromatography-electrospray system are disclosed. The droplet/electrospray device (100) comprises a substrate (102) defining a channel (104) between an entrance orifice (106) on an injection surface (108) and an exit orifice on an ejection surface (112), a nozzle (110) defined by a portion recessed from the ejection surface (112) surrounding the exit orifice, and an electrode (122) for application of an electric potential to the substrate (102) to optimize and generate droplets or an electrospray (62). A plurality of these electrospray devices (100) can be used in the form of an array of miniaturized nozzles. The liquid chromatography-electrospray device (160) comprises a separation substrate (162) defining an introduction channel (164) between an entrance orifice and a reservoir (166) and a separation channel (168) between the reservoir (166) and an exit orifice (170), the separation channel (168) being populated with separation posts (174) perpendicular to the fluid flow.

Patent Agency Ranking